Production of structured designer particles with high encapsulation capacities and efficiencies. This project aims to develop a superior encapsulation technology that is capable of producing particles with precisely controlled physical and chemical properties. The technology has application in a wide range of industries requiring packaging active ingredients into particle form to achieve desirable end-use performances. It has an economic impact of multibillion dollars per annum. In particular, i ....Production of structured designer particles with high encapsulation capacities and efficiencies. This project aims to develop a superior encapsulation technology that is capable of producing particles with precisely controlled physical and chemical properties. The technology has application in a wide range of industries requiring packaging active ingredients into particle form to achieve desirable end-use performances. It has an economic impact of multibillion dollars per annum. In particular, it will facilitate the release of new drugs to the market for the pharmaceutical industry, and increase the range and improve the availability of quality foods for the food industry. This will bring about a healthier life style to the Australian population.Read moreRead less
Controlled Crystallisation of Bioactives. The new technologies developed in this project for bioactive recovery and particle design will allow the development of new value added products for Australia's growing biotechnology industry, especially in pharmaceuticals, neutraceuticals and functional foods. Two PhD students will receive excellent research training to then move into research and development in these industries.
Particle Design for Recovery and Delivery of Bioactives. This project will develop new strategies for economically viable recovery of bioactives from complex solutions, slurries and sludges of biomaterials eg. waste streams from milk and soy bean processing, and fermentation broths. These bioactives, often proteins, have growing applications as high value drugs, nutriceuticals and food additives but are difficult to separate and to maintain in an active form. Crystallisation will be used as a ....Particle Design for Recovery and Delivery of Bioactives. This project will develop new strategies for economically viable recovery of bioactives from complex solutions, slurries and sludges of biomaterials eg. waste streams from milk and soy bean processing, and fermentation broths. These bioactives, often proteins, have growing applications as high value drugs, nutriceuticals and food additives but are difficult to separate and to maintain in an active form. Crystallisation will be used as a primary separation technique. Molecular studies of protein interactions will be used to predict good crystallisation conditions and linked to process crystallisation studies. Both standard and novel particle design strategies will be used to control crystal size and morphology, as well as package the boactive in a deliverable form without loss of activity.Read moreRead less
Particle design and recovery of bioactives by crystallisation and precipitation. This project will develop new strategies for economically viable recovery of bioactives from complex solutions of biomaterials eg. separation of biopharmaceuticals from genetically engineered cell culture, food ingredient processing, functional food and nutraceutical extraction from natural sources. Crystallisation and precipitation will be used as primary separation techniques. We propose a new paradigm in which ....Particle design and recovery of bioactives by crystallisation and precipitation. This project will develop new strategies for economically viable recovery of bioactives from complex solutions of biomaterials eg. separation of biopharmaceuticals from genetically engineered cell culture, food ingredient processing, functional food and nutraceutical extraction from natural sources. Crystallisation and precipitation will be used as primary separation techniques. We propose a new paradigm in which molecular studies of protein interactions will be used to predict good crystallisation conditions and linked to process crystalliation studies. Studies will use a model system of egg white protein mixtures and a real system of industrial importance - the purification of valuable protein products from soy beans (valued at $500 million per year world wide). Soy beans studies will include pilot scale tests at Dupont's industrial reseach laboratories.Read moreRead less
Exploring and harnessing mobile DNA: Integrons and gene cassettes in natural populations of Bacteria. Bacteria respond rapidly to environmental change by acquiring new genes via lateral gene transfer. The integron/gene cassette system is important in this process as it is found in an increasingly broad range of bacteria. As well as being common, we have shown that the system is associated with an unprecedented amount of genetic novelty. Here we explore the limits of this novelty and its con ....Exploring and harnessing mobile DNA: Integrons and gene cassettes in natural populations of Bacteria. Bacteria respond rapidly to environmental change by acquiring new genes via lateral gene transfer. The integron/gene cassette system is important in this process as it is found in an increasingly broad range of bacteria. As well as being common, we have shown that the system is associated with an unprecedented amount of genetic novelty. Here we explore the limits of this novelty and its contribution to bacterial evolution. In so doing we have the potential to identify new commercially important genes and develop enabling technologies. These discoveries could produce beneficial outcomes for exploitation by a wide range of Australian industries.Read moreRead less
The first structure/function-derived starches for the food and related industries. The project will use equipment and theory, developed in Australia, to create the first understanding of the characteristics that govern the performance of complex polymers as emulsifiers. The insights so gained will be a key step towards developing improved modified starches for the food and other industries. These advances will also provide the science by which new modified starches can be produced from sorghum, ....The first structure/function-derived starches for the food and related industries. The project will use equipment and theory, developed in Australia, to create the first understanding of the characteristics that govern the performance of complex polymers as emulsifiers. The insights so gained will be a key step towards developing improved modified starches for the food and other industries. These advances will also provide the science by which new modified starches can be produced from sorghum, a drought-resistant crop well suited to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100085
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Soft matter and responsive materials characterisation facility. The processing of minerals, foods and pharmaceutical materials underpins the delivery of these materials to the community. The industries associated with the named areas have cost-driven demands for higher throughput and constraints imposed by water and energy conservation requirements. Technological advances in the processing of soft matter and responsive materials therefore offer a gateway to revolutionary changes in many aspects ....Soft matter and responsive materials characterisation facility. The processing of minerals, foods and pharmaceutical materials underpins the delivery of these materials to the community. The industries associated with the named areas have cost-driven demands for higher throughput and constraints imposed by water and energy conservation requirements. Technological advances in the processing of soft matter and responsive materials therefore offer a gateway to revolutionary changes in many aspects of our everyday lives. The outcomes from research addressing these classes of advanced materials will translate into improvements in Australian industries and in training the next generation of world leading Australian scientists and engineers using state-of-the-art technology.Read moreRead less