Surface Modification of Spray-Dried Powders By Surface-Active Proteins. Internal wall deposits in spray dryers lead to product degradation and pose fire hazards. This situation has limited the manufacturing of high value bio-food powders by the Australian bio-food and dairy industry, which exports 13% of the milk powder in the world. The specific economic benefits to Australia from this project arise from innovative surface modification of powder particles by proteins, development of scientific ....Surface Modification of Spray-Dried Powders By Surface-Active Proteins. Internal wall deposits in spray dryers lead to product degradation and pose fire hazards. This situation has limited the manufacturing of high value bio-food powders by the Australian bio-food and dairy industry, which exports 13% of the milk powder in the world. The specific economic benefits to Australia from this project arise from innovative surface modification of powder particles by proteins, development of scientific instruments and predictive tools based on Computational Fluid Dynamics (CFD). These outcomes will lead to production of free flowing powders from bio-food materials.Read moreRead less
Production of structured designer particles with high encapsulation capacities and efficiencies. This project aims to develop a superior encapsulation technology that is capable of producing particles with precisely controlled physical and chemical properties. The technology has application in a wide range of industries requiring packaging active ingredients into particle form to achieve desirable end-use performances. It has an economic impact of multibillion dollars per annum. In particular, i ....Production of structured designer particles with high encapsulation capacities and efficiencies. This project aims to develop a superior encapsulation technology that is capable of producing particles with precisely controlled physical and chemical properties. The technology has application in a wide range of industries requiring packaging active ingredients into particle form to achieve desirable end-use performances. It has an economic impact of multibillion dollars per annum. In particular, it will facilitate the release of new drugs to the market for the pharmaceutical industry, and increase the range and improve the availability of quality foods for the food industry. This will bring about a healthier life style to the Australian population.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Improving biological nitrogen removal by enhanced mixing in non-aerated bioreactors. Mixing has been identified as a key factor in achieving enhanced performance out of existing and upgraded bioreactors. There is currently a poor understanding of the relationship between non-ideal flow and performance in wastewater treatment bioreactors. The project will determine this relationship and subsequently use it to show how reactor performance can be improved, providing first criteria by which mixing c ....Improving biological nitrogen removal by enhanced mixing in non-aerated bioreactors. Mixing has been identified as a key factor in achieving enhanced performance out of existing and upgraded bioreactors. There is currently a poor understanding of the relationship between non-ideal flow and performance in wastewater treatment bioreactors. The project will determine this relationship and subsequently use it to show how reactor performance can be improved, providing first criteria by which mixing can be assessed, and second a systematic methodology for improving reactor performance by improving mixing.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Discrete Element Method for Analysis and Design of Pharmaceutical Encapsulation. Tablets represent the preferred method of dose delivery in the pharmaceutical industry, with over 80% of the market. PressFit - gelcaps have recently been developed, which encase a tablet core within a gelatin coating. The product combines the consumer appeal of capsules with the processing convenience of tablets, and provides a high degree of tamper-resistance. An important issue is that the caplets are required ....Discrete Element Method for Analysis and Design of Pharmaceutical Encapsulation. Tablets represent the preferred method of dose delivery in the pharmaceutical industry, with over 80% of the market. PressFit - gelcaps have recently been developed, which encase a tablet core within a gelatin coating. The product combines the consumer appeal of capsules with the processing convenience of tablets, and provides a high degree of tamper-resistance. An important issue is that the caplets are required to have very precise dimensional precision, an issue not previously of high priority for tabletting . This project seeks to enhance the competitive advantage of this new technology, through a combination of advanced mathematical modeling supported by experiments.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100569
Funder
Australian Research Council
Funding Amount
$372,952.00
Summary
Recovering helium from Australia’s natural gas: A case study for advanced adsorption processes to concentrate dilute gases. This project will deliver breakthroughs in gas separation technologies for the production of helium from natural gas. Global demand for helium in critical medical, scientific and industrial applications is projected to grow at around five per cent per annum. To overcome the forecast short falls in helium production, new low cost and energy efficient technologies to recover ....Recovering helium from Australia’s natural gas: A case study for advanced adsorption processes to concentrate dilute gases. This project will deliver breakthroughs in gas separation technologies for the production of helium from natural gas. Global demand for helium in critical medical, scientific and industrial applications is projected to grow at around five per cent per annum. To overcome the forecast short falls in helium production, new low cost and energy efficient technologies to recover helium from natural gas fields must be developed. This project will contribute novel microporous adsorbents, a better understanding of helium sorption kinetics and general methodologies for design of pressure swing adsorption processes to concentrate dilute mixtures.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100119
Funder
Australian Research Council
Funding Amount
$424,607.00
Summary
Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughpu ....Manipulation of non-wetting droplets for cell culture. We have recently discovered an innovative and interdisciplinary approach for manipulating non-wetting droplets called “liquid marbles” as a platform for three-dimensional cell culture. This project aims to elucidate the fundamental physics underpinning the electrostatic handling concept of this platform technology. The project is expected to deliver an inexpensive but sophisticated cell culture platform that is well-suited for high-throughput drug screening and preparing cells for implantation therapy. Significant benefits for end users in pharmaceutical industry, life sciences research and hospitals are expected from the project and the application of the developed technology.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less