Positional Candidate Targets For Multiple Ovulation Genes
Funder
National Health and Medical Research Council
Funding Amount
$272,036.00
Summary
The frequency of non-identical twins is associated with fertility in individuals and populations, although we know little about mechanisms for twinning or effects on fertility. The likelihood for giving birth to non-identical twins is influenced by genetic factors. The probability of a subsequent twin pregnancy is increased fourfold in mothers of twins and roughly doubled for women whose mother or sister has had non-identical twins. Understanding why some women are more likely to have twins will ....The frequency of non-identical twins is associated with fertility in individuals and populations, although we know little about mechanisms for twinning or effects on fertility. The likelihood for giving birth to non-identical twins is influenced by genetic factors. The probability of a subsequent twin pregnancy is increased fourfold in mothers of twins and roughly doubled for women whose mother or sister has had non-identical twins. Understanding why some women are more likely to have twins will help us find key pathways that control normal ovarian function and important factors that influence success in assisted reproduction. The aim of this project is to search for these genes in families with two sisters who have given birth to non-identical twins. Previous studies have identified one strong target region and two possible regions containing genes for increased twinning. We now have additional families and will examine each region in more detail. We will also look for genes within each region that could be responsible for variation in twin frequency.Read moreRead less
Women are born with a limited supply of eggs and are unable to make new eggs after birth. Because of this, the number and health of eggs established within the ovary early in life influence the length of time for which a female will be fertile, her age at menopause, and the health of her offspring. This project aims to shed some light on the mechanisms that control egg supply and reproductive longevity in women by investigating the role of the cell death protein Bid within the ovary.
I am a basic scientist with an interest in the cellular biology of the ovary, and the roles of the matrix between cells of the ovary in controlling fertility and hormone synthesis.
The Effect Of Oxygen Tension On Primary And Primordial Follicle Activation In The Primate Ovary
Funder
National Health and Medical Research Council
Funding Amount
$403,956.00
Summary
Oncofertility, bridges oncology and reproductive medicine in order to apply new fertility preservation options for young patients with fertility-threatening diseases or treatments. Development of the three dimensional (3-D) tissue culture system for follicle maturation is a novel method of replicating the native environment of the growing egg. The ultimate goal of the project is to develop and optimise an in vitro culture procedure that can be translated to support human follicle development.