A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential ....A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential therapeutic possibilities.Read moreRead less
Proteome mapping of the model fungal plant pathogen Stagonospora nodorum using LC-LC-MS/MS. Stagonospora nodorum is a fungus that causes leaf and glume blotch disease on wheat. This disease alone causes $55 million dollars in yield losses per annum in Australia. This project aims to identify the proteins produced by Stagonospora nodorum through the development of a new proteomics technique. Two clear benefits to the community resulting from this project will emerge. The first will be the expert ....Proteome mapping of the model fungal plant pathogen Stagonospora nodorum using LC-LC-MS/MS. Stagonospora nodorum is a fungus that causes leaf and glume blotch disease on wheat. This disease alone causes $55 million dollars in yield losses per annum in Australia. This project aims to identify the proteins produced by Stagonospora nodorum through the development of a new proteomics technique. Two clear benefits to the community resulting from this project will emerge. The first will be the expert training of a student in proteomics, a skill that is keenly sought. Secondly, the identification of these pathogen proteins will lead to new strategies to better control the disease and secure the supply of wheat.Read moreRead less
ARC Centre of Excellence - In Plant Energy Biology (CPEB). Plant cell metabolism underlies the synthesis of important products in crops, and subtle changes in metabolism can enhance germination rates, early seedling vigour, biomass/yield, and tolerance to harsh environments. Research in CPEB will focus on control of this metabolism. Its expertise will enhance Australia's participation in major international research efforts directly relevant to sustainable agriculture in a country with fragile/ ....ARC Centre of Excellence - In Plant Energy Biology (CPEB). Plant cell metabolism underlies the synthesis of important products in crops, and subtle changes in metabolism can enhance germination rates, early seedling vigour, biomass/yield, and tolerance to harsh environments. Research in CPEB will focus on control of this metabolism. Its expertise will enhance Australia's participation in major international research efforts directly relevant to sustainable agriculture in a country with fragile/degrading ecosystems. The research will provide new approaches for enhancing quality metabolite traits important for human health. It will further strengthen our international leadership in plant energy science, and will strengthen Australia's research training in systems biology to influence plant function.Read moreRead less