Dental caries (tooth decay) is initiated by demineralisation of tooth hard tissue by organic acids produced by dental plaque bacteria from dietary sugars. The disease is a major public health problem and has an estimated economic burden in Australia of over $1 billion p.a. being higher than that for any other dietary-related disease. We have discovered and patented a novel amorphous calcium fluoride phosphate that is stabilised by phosphopeptides from the bovine milk protein casein. These comple ....Dental caries (tooth decay) is initiated by demineralisation of tooth hard tissue by organic acids produced by dental plaque bacteria from dietary sugars. The disease is a major public health problem and has an estimated economic burden in Australia of over $1 billion p.a. being higher than that for any other dietary-related disease. We have discovered and patented a novel amorphous calcium fluoride phosphate that is stabilised by phosphopeptides from the bovine milk protein casein. These complexes, designated CPP-ACFP, have the potential to provide superior clinical efficacy in preventing dental caries and treating and repairing early stages of disease. The aims of this project therefore are (i) to develop topical formulations of CPP-ACFP for application to teeth to repair early stages of decay and (ii) to characterise the three-dimensional structure of the CPP-ACFP complexes. The significance of this work is that a superior and novel treatment for dental caries may be developed as well as providing insight into the structure of organically-stabilised amorphous calcium phosphate and its role in biomineralisation processes.Read moreRead less
Natural History And Longterm Impact Of Dental Fluorosis
Funder
National Health and Medical Research Council
Funding Amount
$345,184.00
Summary
Dental fluorosis is an important aspect of oral health because: perception and concerns about fluorosis influence perspective and success of fluoride programs; and advices on fluoride use are based on a risk-benefit tradeoff. This study is expected to report changes in fluorosis, its longterm impact and evaluate fluorosis and caries trade-off. This will be the first study of the natural history of fluorosis. Findings will have significance for individuals, dental profession and health policy.
Determinants Of The Oral Health Of Adults Entering The Third Decade Life-stage
Funder
National Health and Medical Research Council
Funding Amount
$201,500.00
Summary
There has been a strong investment in the oral health of Australian children and their oral health has greatly improved. However, there are a number of indications that not all the gains in child and adolescent oral health are not carried through to the next life stage, adulthood. Somewhere in the intervening years, much of the gains in oral health invested in children and adolescents are dissipated. Hence, the purpose of this proposed research is to document the nature, distribution and determi ....There has been a strong investment in the oral health of Australian children and their oral health has greatly improved. However, there are a number of indications that not all the gains in child and adolescent oral health are not carried through to the next life stage, adulthood. Somewhere in the intervening years, much of the gains in oral health invested in children and adolescents are dissipated. Hence, the purpose of this proposed research is to document the nature, distribution and determinants of oral health among South Australian 29 year olds so as to identify points of intervention to maintain Australian's improved oral health further into adulthood. The specific aims of the research are to document the oral health of a cohort of 29 year olds describe their dental life history and key proximate influences on their oral health identify significant determinants of their oral health to compare the cohort with a representative SA sample of the same age. This project will approach some 3,763 29 year old adults who participated in earlier research as 13 year olds in 1988-89. It will also compare these adults with a random sample of 557 further 29 year olds from the SA Electoral Roll. Participants will be interviewed and then dentally examined, providing a range of key outcome measures on oral health status and explanatory factors from when they were 13 years old, their dental history and circumstances as 29 year olds. The research project is expected to provide detailed documentation of the prevalence and severity of oral disease and its distribution in an adult cohort, and exploration of the dental life history and current determinants of the oral disease observed. It is anticipated that the strength of hypothesised relationships of determinants will have direct policy implications.Read moreRead less
Probing Developmental Causes Of Soft Tooth Enamel With Novel Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$470,112.00
Summary
Tooth decay is one of the most costly diseases in Australia and was recently called a national tragedy by the Prime Minister. The risk of decay increases if teeth don't harden properly in childhood. This project aims to clarify the causes of soft enamel and identify ways to prevent it. Two new test systems will be used to see how antibiotics and fluoride affect enamel hardening. Our findings will help the battle against tooth decay and guide the safe use of medicines in children.
Is Non-invasive Management Of Dental Caries In Private Practice Cost-effective? A Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$325,136.00
Summary
Despite evidence to the contrary, dentists routinely fill decayed teeth that, managed preventively, would be likely to repair (arrest). The probable cost to society of this approach is enormous. Modeling indicates that each new dental filling is likely to cost an average of $1811 (US) over the life-cycle of a tooth. This figure includes re-treatment costs, and the increased likelihood of more expensive re-treatment in future, such as root canal treatment and tooth crowning. An examination of the ....Despite evidence to the contrary, dentists routinely fill decayed teeth that, managed preventively, would be likely to repair (arrest). The probable cost to society of this approach is enormous. Modeling indicates that each new dental filling is likely to cost an average of $1811 (US) over the life-cycle of a tooth. This figure includes re-treatment costs, and the increased likelihood of more expensive re-treatment in future, such as root canal treatment and tooth crowning. An examination of the societal costs involved is likely to reveal this amount to be an under-estimate; consider the costs borne by sectors outside health: days lost to work, lost productivity. Further, we should consider costs to families: travel time and costs, childcare, the opportunity cost of items forgone in order to pay for the dental treatment. Despite this, a recent systematic review of dental caries prevention concluded 'there is presently no proof, in published economic evaluations of the cost-effectiveness of caries-preventive measures'. The authors highlighted a lack of methodologically sound studies. This research will compare a targeted preventive program to standard care within private dental practices. Prior to an alternative approach being introduced, an assessment of effectiveness and cost-effectiveness is needed. It is through such assessment that the value of the comparator can be assessed and our precious health dollars saved. The radical surgical approach (filling) that evolved to deal with the caries problem is entrenched in both public and private institutions that teach and deliver dental care. The strategic element is to reorient the services provided by general practices towards to goal of delivering a substantial reduction in the need to drill teeth, while maximizing the opportunity for a non-invasive remineralization approach that has been successfully demonstrated in in-vitro, in-vivo, and in small scale clinical trials.Read moreRead less