Novel Fluorogenic Probes For The Selective Detection Of Pathogenic Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$542,489.00
Summary
Current methods for the detection of multi-resistant organisms either require expensive instrumentation and expert analysts or are simple, but require 24-48 hours for bacterial identification. The ideal surveillance method would be cost effective, rapid, reliable, and simple to perform. This project aims to prepare a range of fluorescent substrates for incorporation into growth media which will then be evaluated for the specific identification of individual multi-resistant organisms, e.g. MRSA.
The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
Unravelling Mechanotransduction Pathways In The Heart
Funder
National Health and Medical Research Council
Funding Amount
$949,956.00
Summary
This project addresses the still unresolved question of involvement of mechanosensitive ion channels in heart hypertrophy and arrhythmias including ventricular arrhythmias. These pathological conditions are a cause of a broadening fiscal healthcare burden in Western societies. Consequently, investigating the role of this class of ion channels in heart disease presents a priority for medical science and a great opportunity to improve the health outcomes for the Australian people.
A Novel Diagnostic Method To Determine The Likelihood Of Kidney Fibrosis And Progressive CKD In Patients With Diabetes Mellitus And Other Forms Of Chronic Proteinuric Renal Disease
Funder
National Health and Medical Research Council
Funding Amount
$508,848.00
Summary
The project aims to develop a new non-invasive diagnostic method to detect patients with early CKD, a major health burden that is mainly driven by obesity and diabetes. It will specifically determine whether exfoliated tubular cells in the urine reflect kidney disease progression and hence provide a proof of concept on whether our newly developed hyperspectral technique can be used as a non-invasive diagnostic tool to identify patients with kidney disease.