Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100194
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met th ....Optical diagnostics for the investigation of high-speed energetic processes. Optical diagnostics for the investigation of high-speed energetic processes:
The project seeks to establish equipment to enable the investigation of high-speed energetic processes. Such processes, where large amounts of energy are released over a short time frame, occur in nature and almost every field of science and engineering, and their investigation is a formidable challenge. This challenge is designed to be met through the combined use of state-of-the-art flow visualisation, thermography and spectrometry equipment. These diagnostics would open avenues into so far impossible or difficult to conduct research on highly transient phenomena in various research fields, which include various aspects of fluid mechanics, combustion, and fracture mechanics. The equipment would be instrumental in the design of better and innovative machines, materials, instruments and processes.Read moreRead less
Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microflui ....Atomic forces for sorting ultrabright nanodiamonds. This project aims to sort fluorescent nanodiamonds according to their brightness using atomic radiation pressure. Fluorescent nanodiamonds can overcome all limitations associated with conventional fluorescent bio-labels. While readily available, their brightness varies greatly, so a method for yielding high-quality material with consistent brightness is needed. This project combines techniques from laser manipulation of cold atoms and microfluidics to create an optofluidic method of particle separation. The proposed device could sort nanodiamonds more than a billion times faster than active sorting techniques. This is expected to lead to better tools for bio-imaging and bio-manipulation.Read moreRead less
Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100085
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the character ....Micro/Nanofluidic Characterisation Facility. Micro/nanofluidic characterisation facility: Microfluidics promises to enable diagnosis of medical diseases using devices which perform laboratory experiments but on a scale which means the entire system can be hand-held. Whilst the fabrication of miniaturised fluidic channels is well established, the challenge is to bring additional functions onto the chip reducing the reliance on external pumps and electronics. This facility will allow the characterisation of technologies which address on-chip sample preparation using pulsed ultrasonic waves, filtration and pumping using nanofluidic structures, and detection using on-chip circuitry. As such the facility will have the capability to directly address the challenges which must be met to allow diagnosis in rural underprivileged areas. Read moreRead less
Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied ....Acoustic single cell traps: Understanding the woods by examining the trees. This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied at a population level. To trap single cells, the acoustic wavelength excited must be reduced to the order of a cell diameter. By enabling the analysis of different responses due to subtle cell difference, information pertinent to infection pathways and drug response could be gathered.Read moreRead less
Bright x-ray beams from laser-driven microplasmas. This project aims to develop a new generation of bright, laser-like x-ray sources for laboratory use. X-ray sources underpin key diagnostic techniques in materials science, advancing applications from structural engineering through to ore processing and energy storage. However, the limited brightness of present-day laboratory x-ray sources restricts the utility and range of these diagnostic techniques. This research intends to use intense lasers ....Bright x-ray beams from laser-driven microplasmas. This project aims to develop a new generation of bright, laser-like x-ray sources for laboratory use. X-ray sources underpin key diagnostic techniques in materials science, advancing applications from structural engineering through to ore processing and energy storage. However, the limited brightness of present-day laboratory x-ray sources restricts the utility and range of these diagnostic techniques. This research intends to use intense lasers to create microscopic plasmas and drive high harmonic generation. The high harmonic generation process is already used to create laser-like ultraviolet light. By optimising the characteristics of the plasma medium, the project aims to extend bright high harmonic generation to the x-ray regime.Read moreRead less
Nanoparticle radiosensitisation. This project aims to develop new knowledge through a better understanding of physics interactions of particles in compounds with sub-micron size. Research on radiosensitisation by sub-micrometre sized nanoparticles (NPs) is hot worldwide because it could treat cancer, but the physical/physico-chemical/biological mechanism of radiosensitisation is unclear because no physical models describe particle interactions at nanometre scale in solid state nanometre sized ob ....Nanoparticle radiosensitisation. This project aims to develop new knowledge through a better understanding of physics interactions of particles in compounds with sub-micron size. Research on radiosensitisation by sub-micrometre sized nanoparticles (NPs) is hot worldwide because it could treat cancer, but the physical/physico-chemical/biological mechanism of radiosensitisation is unclear because no physical models describe particle interactions at nanometre scale in solid state nanometre sized objects. This project will develop and evaluate specialised physics models to describe particle interactions in NPs and help optimise nanoparticle technology. It will develop expertise in Australia in physics modelling for nanomedicine and other applications of nanotechnology exposed to radiation (e.g. telecommunications, aviation and space).Read moreRead less
In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual ....In vivo molecular imaging using engineered affinity reagents and fluorescent laser scanning confocal endomicroscopy. The goal of this project is to develop laser scanning confocal endomicroscopy as a tool for basic scientific discovery and rapid detection of disease biomarkers. The cutting-edge instrument and associated technologies will provide scientists with unprecedented access to dynamic biological processes as they occur in real-time. In addition, it will enable the development of virtual biopsies and instant diagnosis without the need for costly and time-consuming histopathological reports. Thus, it will not only drive transformative research but also transform health care delivery. It will also be a major boost to the Australian biotechnology industry with potential for enormous economic benefits.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100229
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A prototype Scanning Helium Atom Microscope (SHeM) for soft materials. The scanning helium atom microscope (SHeM) has been a tantalising prospect since the birth of quantum physics. The SHeM would have unparalleled resolution and would be completely non-damaging; potentially revolutionising the imaging of soft delicate materials. This project will develop the first SHeM instrument in Australia to study soft matter.
Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team ....Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team recently invented the scanning helium atom microscope (SHeM), which can image surfaces non-destructively with nanoscale resolution. They will use the SHeM to determine the new fundamental physics that underpins the imaging mechanism. Outcomes include turning SHeM into a tool that materials and biological scientists can use in laboratories worldwide.Read moreRead less