5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging ....5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging flow cytometer (5D IFC) capable of continuous assessment of potentially entire blood volume in a living mice without removing fluid out of the body. The project represents a major advancement beyond any existing flow cytometer and overcome the engineering limits of state-of-art laser scanning imaging devices.Read moreRead less
Transport control in multi-species fluid suspensions. This project aims to develop novel methods of controlling multi-species particles in fluid suspensions, such as microorganisms in wounds. Physical methods of control offer additional opportunities for wound healing in the era of increased microbial resistance to antibiotics. The project will develop methods of controlling the local concentration of microorganisms, such as bacteria and cells, using wave-driven turbulent transport and active sy ....Transport control in multi-species fluid suspensions. This project aims to develop novel methods of controlling multi-species particles in fluid suspensions, such as microorganisms in wounds. Physical methods of control offer additional opportunities for wound healing in the era of increased microbial resistance to antibiotics. The project will develop methods of controlling the local concentration of microorganisms, such as bacteria and cells, using wave-driven turbulent transport and active synthetic agents. The proposed methods will also benefit applications in microfluidics, liquid metamaterials, micro-assembly and technologies for cleaning liquid surfaces. The project will advance our fundamental knowledge of particle interaction with matter waves.Read moreRead less
Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understan ....Unravelling the neutron lifetime puzzle with lattice quantum chromodynamics. This project will perform supercomputer simulations to confront one of the outstanding puzzles of nuclear and particle physics, the neutron lifetime. New knowledge will be generated through the development of novel theoretical and numerical techniques to increase the precision of the leading theoretical inputs required to predict the neutron lifetime. The outcomes will provide crucial theoretical guidance into understanding the neutron; helping to guide the next-generation neutron experiments, from particle physics to applications in advanced materials science. The results will have immediate benefit by resolving the neutron lifetime puzzle, while enabling Australian scientists to take a leadership role in this area of fundamental science.Read moreRead less
Quantum tunnelling of composite systems. This project aims to investigate profound physics problem of quantum tunnelling of composite systems such as atoms, molecules and atomic nuclei. Using new theoretical concepts and tools to describe low-energy fusion between atomic nuclei, this project is expected to generate new knowledge and improve understanding of nuclear reactions, the formation of elements in the cosmos, and underpin future nuclear technologies. The project aims to leverage Australia ....Quantum tunnelling of composite systems. This project aims to investigate profound physics problem of quantum tunnelling of composite systems such as atoms, molecules and atomic nuclei. Using new theoretical concepts and tools to describe low-energy fusion between atomic nuclei, this project is expected to generate new knowledge and improve understanding of nuclear reactions, the formation of elements in the cosmos, and underpin future nuclear technologies. The project aims to leverage Australian capacity in quantum and nuclear theory to produce the first predictive model of quantum tunnelling with a modern microscopic treatment of nuclear dynamics. It will provide new theoretical guidance to experimental programs with exotic beams and focussing on nucleosynthesis.Read moreRead less
Atomic sensors for dark matter, rotation and magnetic fields. This project aims to develop ultra-high-performance sensors. The research will explore new methods for using the magnetic and optical properties of atomic gases to enable multi-parameter sensing without crosstalk between measurements. It is expected that techniques will be developed to allow simultaneous sensing of rotation and magnetic fields using devices that are compact, ultra-precise and energy efficient. It is also anticipated t ....Atomic sensors for dark matter, rotation and magnetic fields. This project aims to develop ultra-high-performance sensors. The research will explore new methods for using the magnetic and optical properties of atomic gases to enable multi-parameter sensing without crosstalk between measurements. It is expected that techniques will be developed to allow simultaneous sensing of rotation and magnetic fields using devices that are compact, ultra-precise and energy efficient. It is also anticipated that these new atomic sensors will support a global network looking for dark matter, which although never seen, is thought to make up 85% of the mass of the universe. The outcomes are expected to benefit medical science, geo-exploration, high-tech manufacturing, navigation and our understanding of the universe.Read moreRead less
Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expecte ....Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expected to deliver new experimental data on novel surface materials exposed to a hypersonic flow environment and computer models that can simulate their cooling effect. This investigation will contribute towards enabling technologies for sustained hypersonic flight by overcoming critical head load limitations.Read moreRead less
Quantum thermalisation: a new framework for nuclear collisions. This project aims to quantify and model the processes that lead to quantum thermalisation in nuclear collisions. Thermalisation is critical to the synthesis of new superheavy elements, production of medical isotopes, and creation of heavy elements in the cosmos. Yet quantum thermalisation in nuclear systems is not understood, causing models to be wrong by up to a factor of 100. This project will determine the routes to thermalisatio ....Quantum thermalisation: a new framework for nuclear collisions. This project aims to quantify and model the processes that lead to quantum thermalisation in nuclear collisions. Thermalisation is critical to the synthesis of new superheavy elements, production of medical isotopes, and creation of heavy elements in the cosmos. Yet quantum thermalisation in nuclear systems is not understood, causing models to be wrong by up to a factor of 100. This project will determine the routes to thermalisation in nuclear systems by combining the latest concepts in many body quantum physics with enhancements to Australia’s precision measurement capabilities. The project will enable new fundamental tests of quantum mechanics and benefit broader applications of nuclear collisions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100197
Funder
Australian Research Council
Funding Amount
$438,000.00
Summary
In one zeptosecond: quantifying energy dissipation in heavy element fusion. This project aims to understand the process of energy dissipation in superheavy element fusion reactions. Using state-of-the art facilities unique to Australia, the first detailed measurements of the crucial early stages of these reactions will be made. This is expected to generate significant fundamental knowledge on why some superheavy element fusion reactions succeed, and why others fail. The outcomes are expected to ....In one zeptosecond: quantifying energy dissipation in heavy element fusion. This project aims to understand the process of energy dissipation in superheavy element fusion reactions. Using state-of-the art facilities unique to Australia, the first detailed measurements of the crucial early stages of these reactions will be made. This is expected to generate significant fundamental knowledge on why some superheavy element fusion reactions succeed, and why others fail. The outcomes are expected to significantly advance the fundamental understanding of nuclear reactions, and provide key guidance to international opportunities to create new superheavy elements and isotopes. Expected benefits include improving cancer treatments, understanding element abundance in the universe and improved safety in nuclear technologies.Read moreRead less