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Clinical And Public Health Interventions For Preventing Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$137,595.00
Summary
Professor Neal’s research has two main components – the first will identify new drug therapies for the management of diabetes and the second will provide new evidence about ways to improve the healthiness of the food supply in Australia.
Cardiovascular disease (CVD) is responsible for one third of all deaths globally. Most CVD can be prevented by addressing behavioral risk factors, and it is widely accepted that increasing the intake of fruits, vegetables and whole grains could cut CVD risk and associated costs more than 25%. However, surprisingly little is known about the impact of individual foods and beverages and their components on vascular health, or the mechanisms involved. This is the prime research focus.
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
Through this Australia Fellowship, Prof Keall and his tream will substantially improve the accuracy and effectiveness of radiation therapy for cancer by developing new techniques that will be able to ‘target’ a tumour in real-time and ‘concentrate fire’ on the most resistant and aggressive parts of it. Success in physiological targeting will create a paradigm shift in radiation therapy and could literally be a lifesaver. It’s a big challenge, but if this five-year research program succeeds, it w ....Through this Australia Fellowship, Prof Keall and his tream will substantially improve the accuracy and effectiveness of radiation therapy for cancer by developing new techniques that will be able to ‘target’ a tumour in real-time and ‘concentrate fire’ on the most resistant and aggressive parts of it. Success in physiological targeting will create a paradigm shift in radiation therapy and could literally be a lifesaver. It’s a big challenge, but if this five-year research program succeeds, it will pay big dividendsRead moreRead less
Mental illness is the largest single cause of disability in Australia. While mental illness is increasingly recognised as a disorder of the brain, a patient’s diagnosis, treatment and prediction of course of outcome is seldom guided by the results of a biological test. My research aims to combine the power of modern brain imaging and cutting-edge bioinformatics to enable a biological approach to the problem of mental illness.
Lipid Biology For Prediction And Prevention Of Psychotic Disorders And Persistent Depression In Young People
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
My vision for the next 5 years is to establish ?-3PUFAs as a first-line treatment for indicated prevention of psychosis and persistent depression, as an alternative to conventional antidepressants for the treatment of moderate-to-severe depressive symptoms in adolescents and to build capacity in this area by training the next generation of researchers.
Public Health Communication Strategies To Reduce Population Smoking Prevalence
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This research program will investigate the potential for and impact of advanced tobacco control policies in reducing population smoking prevalence. My research will assess the effects of tobacco taxation, further tobacco marketing restrictions and mass communication strategies on smoking attitudes and behaviours. I will also extend the methods and measures I have developed in tobacco control to improve health communication in obesity prevention and alcohol harm prevention.
Neurobiological ‘risk’ And ‘resilience’ Biomarkers Of Severe Mental Illness
Funder
National Health and Medical Research Council
Funding Amount
$926,980.00
Summary
Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major burden of disease. We will use sophisticated neuroimaging to examine trajectories of brain growth from childhood to adulthood and identify factors (stress, drugs, inflammation, genes) relevant to risk and resilience to developing these disorders. This will lead to novel early interventions to reduce or ameliorate these conditions.