Molecular Networks And Genomics Of Host Response In Typhoid Fever
Funder
National Health and Medical Research Council
Funding Amount
$487,814.00
Summary
Typhoid fever affects 25 million people annually and is caused by systemic infection with Salmonella Typhi or Paratyphi. With this proposal, we will characterise how different individuals respond differently to typhoid, what ramifications this has for systemic Salmonella infection in humans, and how typhoid can be clinically identified early on, thus giving the patient the best possible chance to avoid complications, injury and potential death.
A Systems Biology Approach To Elucidate Common Principles And Mechanisms Underlying Triplet Repeat Expansion Associated Genetic Defects
Funder
National Health and Medical Research Council
Funding Amount
$1,033,615.00
Summary
Several human genetic diseases that affect the nervous system occur due to expansions of the DNA repeats in the genome. Here, we use a combination of cutting edge technologies such as systems biology and genomics to uncover the common principles and use them to devise novel therapeutic strategies.
Chronic pain will affect most of us at one point in our life, and there is a need for new drugs to manage this condition. The goal of this project is to use a combined state-of-the-art genetics approaches in fruit flies, mice, rats, and humans, to identify and validate new genes that contribute to chronic pain, with the clear long term possibility to develop new strategic therapies to treat chronic pain disease.
The Role Chromatin Remodeling Factors In Epigenetic Regulation Of Cardiac Arrhythmia
Funder
National Health and Medical Research Council
Funding Amount
$854,135.00
Summary
Cardiovascular diseases kill an Australian every 11 minutes. Arrhythmias are of particular alarm since they can lead to significantly higher risk of serious strokes, heart failure, and overall mortality. We combine fruit fly genetics with next generation human genomics approaches to find and functionally validate new genes and mutations regulating arrhythmia in fruit flies and atrial fibrillation in humans, and this work can rapidly identify new avenues to pursue therapeutic intervention