Ocular Implant For The Treatment Of Bacterial Endophthalmitis
Funder
National Health and Medical Research Council
Funding Amount
$483,446.00
Summary
We seek to develop an ocular implant for the treatment of bacterial endophthalmitis. The implant will be a small device that can be administered directly to the affected ocular cavity to release an antibiotic in a controlled manner to clear any infection. The implant will erode and leave no residue. It will be produced from a novel drug-polymer conjugate technology that allows polymer devices that comprise >50% drug to be made.
Novel Silver Nanoparticle Coatings For The Prevention Of Infection Of Biomedical Implants And Devices
Funder
National Health and Medical Research Council
Funding Amount
$455,305.00
Summary
This project targets infections associated with implants and biomedical devices such as catheters, pacemaker leads, knee and hip implants, by the development and evaluation of coatings delivering antibacterial silver ions. The novel coating method is more uniform and reproducible and can be applied to a wide range of biomedical implants and devices. The novel coatings will be tested for antimicrobial effectiveness and safety using cell and tissue culture methods and animal clinical studies.
Development And Application Of A Pressure-sensing Electropalatograph For The Assessment And Treatment Of Speech Disorder
Funder
National Health and Medical Research Council
Funding Amount
$200,750.00
Summary
A multidisciplinary team of researchers aim to develop a unique, advanced, computer-based speech device that speech pathologists can use to assess and treat a variety of speech disorders. The device will record the location, timing and pressure of tongue contacts against the roof of the mouth (palate) during speech using innovative sensors embedded in an artificial plate placed over the roof of the mouth. State-of-the-art 3D graphics will be used to display tongue-to-palate contacts to both spee ....A multidisciplinary team of researchers aim to develop a unique, advanced, computer-based speech device that speech pathologists can use to assess and treat a variety of speech disorders. The device will record the location, timing and pressure of tongue contacts against the roof of the mouth (palate) during speech using innovative sensors embedded in an artificial plate placed over the roof of the mouth. State-of-the-art 3D graphics will be used to display tongue-to-palate contacts to both speech pathologist and patient.Read moreRead less
The Development Of A Cross-strain And Cross-subtype Pre Pandemic Influenza Vaccine Using Savine Technology
Funder
National Health and Medical Research Council
Funding Amount
$159,500.00
Summary
The flu vaccines in use today work by inducing antibodies to surface proteins. Flu causes disease every year but occasionally a new strain arises that is distincly differnet from previous strains and can cause wides spread disease and deaths worldwide. Our new approach is to increase the level of T cells that can recognise and kill flu infected cells from all flu strains.
Web-based Multimedia Information Management System For Use In Remote Diagnosis Of Eye Diseases
Funder
National Health and Medical Research Council
Funding Amount
$196,000.00
Summary
Our aim is to develop a web-based multimedia information management system for use in remote diagnosis of eye diseases. The proposed system will provide medical advice and diagnosis, information and distance education for those working in health care as well as the community, computer-aided diagnosis and assistance in the operational and medical decision-making process. Less expensive health care personnel should be able to use the system with little training in remote and rural areas. Significa ....Our aim is to develop a web-based multimedia information management system for use in remote diagnosis of eye diseases. The proposed system will provide medical advice and diagnosis, information and distance education for those working in health care as well as the community, computer-aided diagnosis and assistance in the operational and medical decision-making process. Less expensive health care personnel should be able to use the system with little training in remote and rural areas. Significantly, the project should empower remote general doctors and nurses by proper access to expert advice, save many remote patients from unnecessary visits to specialist centres on the one hand and allow more proper diagnosis and intervention on the other. It has the potential for significant reductions in the cost of health care delivery, should strengthening the bond between medical services in remote and city areas, provide training and education of local GPs, nurses, health care workers and optometrists and provide web-based disease management systems will provide instant access to health care information. The outcomes of this project are potentially of great significance to remote and rural communities in Australia and around the world. There will be an enormous impact on current health care practices. Significantly, the project should empower remote general doctors and nurses by proper access to expert advice, save many remote patients from unnecessary visits to specialist centres on the one hand and allow more proper diagnosis and intervention on the other. It has the potential for significant reductions in the cost of health care delivery, should strengthening the bond between medical services in remote and city areas, provide training and education of local GPs, nurses, health care workers and optometrists and provide web-based disease management systems will provide instant access to health care information. The outcomes of this project are potentially of great significance to remote and rural communities in Australia and around the world. There will be an enormous impact on current health care practices.Read moreRead less
The Respire_ System: Portable Pulmonary Delivery Platform For Rapid, Flexible And Highly Efficient Treatment Of Elderly, Paediatric And Physically-Compromised Patients With Chronic Respiratory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$599,142.00
Summary
The development of a low-cost miniature drug delivery platform for the treatment of chronic respiratory diseases is proposed. The portable device has already been shown to be significantly more efficient than currently available asthma inhalers. In addition, the device offers the possibility of dose adjustment to account for patient variability, such as age and disease severity, as well as a reduction in patient intervention, thus making it more appropriate for patients unable to self-medicate.
Biological Membrane Transporters: Delivery Of An Oligonucleotide Inhibitor Of Vascular Endothelial Growth Factor (VEGF)
Funder
National Health and Medical Research Council
Funding Amount
$99,750.00
Summary
Choroidal neovascularisation, which is the most severe form of Age Related Macular Degeneration, is the major cause of blindness in the developed world. Gene therapy could be a cure for this disease if the problems associated with the delivery of DNA could be addressed. Our project involves a highly novel strategy for gene delivery involving ion pair formation of lipophilic dendrimers (tree-like compounds with positive charges on the surface). We will develop new DNA-dendrimer complexes and test ....Choroidal neovascularisation, which is the most severe form of Age Related Macular Degeneration, is the major cause of blindness in the developed world. Gene therapy could be a cure for this disease if the problems associated with the delivery of DNA could be addressed. Our project involves a highly novel strategy for gene delivery involving ion pair formation of lipophilic dendrimers (tree-like compounds with positive charges on the surface). We will develop new DNA-dendrimer complexes and test them in a well established animal model for neovascularisation. Successful completion of this project might offer a potential therapy for choroidal neovascularisation, with a good chance of entering into human clinical trials.Read moreRead less
Development Of The Quick Clinical On-line Evidence Based Decision Support System
Funder
National Health and Medical Research Council
Funding Amount
$124,500.00
Summary
Web information retrieval is of increasing importance to health professions. Yet, despite advances in technology, clinicians still have large unmet information needs with significant consequences for the public. QuickClinical is an evidence delivery system that utilises intelligent search filter technology to assist typical clinical tasks like ‘diagnosis’, ensuring only the most relevant evidence is retrieved. This grant will allow a research prototype to be taken to early commercialisation stag ....Web information retrieval is of increasing importance to health professions. Yet, despite advances in technology, clinicians still have large unmet information needs with significant consequences for the public. QuickClinical is an evidence delivery system that utilises intelligent search filter technology to assist typical clinical tasks like ‘diagnosis’, ensuring only the most relevant evidence is retrieved. This grant will allow a research prototype to be taken to early commercialisation stage, ready to be deployed in different environments for different clinical users.Read moreRead less
Novel System For Non-Invasive Delivery Of Drugs To The Interior Of The Eye
Funder
National Health and Medical Research Council
Funding Amount
$200,213.00
Summary
Age-related macular degeneration (AMD) is the leading cause of visual loss for adults in the developed world. Treatment is now by needle injection into the back of the eye, which is painful for the patient and is costly for the health-care system. Seagull Technology Pty Ltd has developed a non-invasive device for treating the back of the eye without the need for a needle injection. This project will test the new device in animals and then move to a first safety study for human AMD patients.