From Understanding The Mechanisms To Implementing Conservative Management Of Musculoskeletal Conditions
Funder
National Health and Medical Research Council
Funding Amount
$2,339,215.00
Summary
Musculoskeletal pain is the leading cause of disability internationally and outcomes are worsening. This work will take a unique approach to study back pain from the mechanisms that occur at the cellular level to the interaction between a person’s physiology and psychology to understand why pain fluctuates, to understand how treatments can be more appropriately tailored for individuals, and to test how people with back pain can be supported to change behaviours and achieve recovery.
Next Generation Of Medical Devices And Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$2,738,220.00
Summary
This Investigator Project will deliver innovative technologies that improve patient wellbeing, make significant economic impact and contribute to answering complex biological questions. This will happen via delivering breakthrough technologies to prevent infections and diagnose diseases – two area that currently require substantial technological advances. In addition to helping patients and clinicians, the project will also deliver solid body of new knowledge that is currently missing.
Realising The World Health Organisation Targets For Elimination Of Cervical Cancer As A Public Health Problem: Effective Implementation And Scale-up Of HPV Vaccination And Cervical Screening In Australia, Regionally, And Globally
Funder
National Health and Medical Research Council
Funding Amount
$2,125,000.00
Summary
This fellowship focuses on improving cancer screening, particularly the implementation of HPV vaccination and cervical screening. CI Canfell will pursue an Australian, regional and global health agenda towards the elimination of cervical cancer. Her work is supporting the successful implementation of the new cervical screening program in Australia, provides crucial support to other countries in the region, and is directly informing the WHO global elimination strategy.
Improving Outcome For People With Heart Diseases Using Digital Health Technologies
Funder
National Health and Medical Research Council
Funding Amount
$606,009.00
Summary
Digital technologies such as smart phones, wearable devices, sensors and artificial intelligence have shown promise to improve human health. However, evidence that these technologies can improve health outcomes in people with heart disease is lacking. My program of research in digital health will address this need and develop new model-of-care for people with heart disease to better monitor their health, take action before their health deteriorates and provide much needed support at home.
Optimising Treatment And Prevention Strategies To Accelerate Malaria Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Elimination of malaria requires the assessment of interventions that not only treat individual infections successfully but also prevent disease at a population level. My proposal brings together data science approaches and mathematical modelling to develop new methods to assess antimalarial treatments and radical population interventions, and identify markers of drug resistance, accelerating malaria elimination efforts and building capacity in this emerging cross-disciplinary field.
Minimising Uptake Of E-cigarettes And Encouraging Cessation Among Australian Adolescents And Adults
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Efforts are needed to address the growing use of e-cigarettes among Australians to prevent potential increases in smoking rates and minimise harm. My research aims to: 1. Develop and test a model examining predictors of e-cigarette use and susceptibility to use among adolescents and adults. 2. Develop, implement, and evaluate messages that effectively minimise uptake and encourage cessation of e-cigarette use. 3. Develop resources for stakeholders that provide guidance on managing use.
Over the next 5 years my team and I plan to study parasite invasion and blood cell enslavement to guide the design of better vaccines and medicines. Malaria as a deadly parasitic disease caused by large-scale infection of the body’s red blood cells. To design more effective vaccines and improved drugs to globally eliminate malaria we need to improve our understanding of how parasites infect and enslave our blood cells so they can grow rapidly and avoid our immune system.
Dangerous Dreams: The Next Era In Paediatric Sleep Research
Funder
National Health and Medical Research Council
Funding Amount
$2,238,220.00
Summary
The amount of time and the quality of our sleep affects every aspect of our health and well-being. The amount of time we sleep is maximal in infants and children because it is promotes normal brain development. Sleep problems affect nearly half of all children and adversely affect both learning and blood pressure. The proposed studies will identify and improve treatment of sleep problems to improve overall physical health and quality of life for these children and their families.
Novel Nanotechnology Strategies For Drug Co-delivery And Combined Therapies In The Brain
Funder
National Health and Medical Research Council
Funding Amount
$1,512,250.00
Summary
Key challenges for treating brain diseases include effective delivery of drugs into the brain and targeted delivery to pathogenic areas. I have developed two world-first drug delivery systems that address these challenges. This project will expand their loading and brain delivery capability to deliver a broad range of novel multiple therapeutics to target sites in the brain. Human brain disease models will be used for systematic preclinical evaluation of novel delivery systems and therapeutics.
A Long-Lasting Oral Drug Delivery System Using Spiky Silica Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
This project aims to develop a novel silica nanoparticle-based delivery system for long-lasting oral drug delivery. The particles will be engineered with a spiky morphology that will increase adhesion to the gastrointestinal tract enabling sustained drug release for days or even weeks. Longer lasting oral drug formulations would make it much easier for patients to adhere to the treatment schedules required in chronic diseases like HIV and increase the effectiveness of therapy.