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Phylogeography, Conservation Genetics and Stocking Management of Perches and Basses. This project will use DNA data to address fundamental questions about the origin and maintenance of biodiversity in a popular and widely distributed fish group. From a conservation perspective, the project will produce a benchmark about management of fish resources. We will investigate questions related to important conservation issues (including the recovery plan of a nationally threatened species) and the mana ....Phylogeography, Conservation Genetics and Stocking Management of Perches and Basses. This project will use DNA data to address fundamental questions about the origin and maintenance of biodiversity in a popular and widely distributed fish group. From a conservation perspective, the project will produce a benchmark about management of fish resources. We will investigate questions related to important conservation issues (including the recovery plan of a nationally threatened species) and the management of stocking activities in recreational fisheries of coastal and inland waters. The latter is particularly relevant to rural communities since they provide both social and economic benefits to rural people.Read moreRead less
Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to p ....Programming of appetite and bodyweight by the interaction of maternal diet and angiotensin during peri-natal life. The project describes a phenotype for appetite and body weight that can be altered by maternal dietary omega-3 PUFA (environmental factors), at a critical period during peri-natal life (developmental phase) and that the effect on body weight is opposite when endogenous angiotensin is increased (hormonal factor). The project aims to discover how these different factors interact to produce the phenotype by defining the critical period and systematically identifying genes that are expressed during this period. The effect of manipulating maternal dietary omega-3 PUFA and the role of angiotensin will then be examined. The project will discover how genetic, hormonal and environmental factors interact during the perinatal period of life to program food intake and body weight in adult life. Read moreRead less
Mechanisms of zinc transport and homeostasis in plants. Zinc deficiency is a widespread factor limiting crop production and affects many soils of southern Australia and around the world. Genetic techniques can be used to identify zinc-efficient crop breeds able to grow well under zinc deficient conditions and able to efficiently deliver zinc to cereal grains to alleviate nutritional zinc-deficiency in humans. This project will identify new genes important in zinc transport and homeostasis in pla ....Mechanisms of zinc transport and homeostasis in plants. Zinc deficiency is a widespread factor limiting crop production and affects many soils of southern Australia and around the world. Genetic techniques can be used to identify zinc-efficient crop breeds able to grow well under zinc deficient conditions and able to efficiently deliver zinc to cereal grains to alleviate nutritional zinc-deficiency in humans. This project will identify new genes important in zinc transport and homeostasis in plants and will ultimately allow their role in zinc efficient crops to be assessed. This will contribute to more rapid and directed strategies in breeding zinc efficient crops.Read moreRead less
Mechanistic characterisation of genotype x environment interactions in sorghum and arabidopsis. Sorghum is an economically important cereal crop for Australia. In Australia, sorghum is used as a staple animal feed and it is very important for the live stock industry. With the predicted changes of temperature and rainfall patterns due to climate change, negative effects on sorghum yield are expected, which can have adverse effects on Australian economy. Our studies will identify and mark genes th ....Mechanistic characterisation of genotype x environment interactions in sorghum and arabidopsis. Sorghum is an economically important cereal crop for Australia. In Australia, sorghum is used as a staple animal feed and it is very important for the live stock industry. With the predicted changes of temperature and rainfall patterns due to climate change, negative effects on sorghum yield are expected, which can have adverse effects on Australian economy. Our studies will identify and mark genes that regulate flowering and seed production in sorghum in response to changes in temperature and light interactions. These studies will help to develop novel sorghum varieties with desirable characters through plant-breeding programmes.Read moreRead less
The development and evolution of the pelvic girdle in basal gnathostomes. Comparing the development of muscles, cartilage and bone in representatives of all three major groups of fish will provide information as to how structures evolved but also how the adult morphology is distributed in phylogeny. Because so little is known about the genetic mechanisms underlying the formation of the pelvic girdle in fish, it is important to start studying a model animal such as the zebrafish. The pathways unc ....The development and evolution of the pelvic girdle in basal gnathostomes. Comparing the development of muscles, cartilage and bone in representatives of all three major groups of fish will provide information as to how structures evolved but also how the adult morphology is distributed in phylogeny. Because so little is known about the genetic mechanisms underlying the formation of the pelvic girdle in fish, it is important to start studying a model animal such as the zebrafish. The pathways uncovered have the potential to describe mechanisms common to all jawed vertebrates, not only common to fish. Understanding the mechanisms that generate major morphological transition in the vertebrate lineage necessarily informs us about our own evolutionRead moreRead less
A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775503
Funder
Australian Research Council
Funding Amount
$255,000.00
Summary
Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement p ....Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement programs such as are based at the Waite Campus. The outputs will include crops with increased tolerance to biotic and abiotic stresses, a reduced dependence on chemical inputs such as fertilisers and improved food quality, with consequent benefits to the environment and human health and nutrition.Read moreRead less
Differentiation of effector and tissue regulatory T cells . Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will gene ....Differentiation of effector and tissue regulatory T cells . Regulatory T cells (Tregs) populate almost every organ of the body and play a central role in preventing inflammation and maintaining health. To exercise these functions, Tregs undergo a developmental program, the details of which are poorly known. This project will utilize newly developed biological tools and state-of-the-art technology to uncover the molecular mechanisms that govern Treg development and function. The project will generate basic scientific knowledge and new intellectual property that will afford new opportunities for research and development. The outcomes of this project will help to devise strategies to treat diseases such as autoimmunity, cancer and metabolic syndrome, and will thus benefit veterinary and human health.Read moreRead less
Defining biologically significant units in spinifex (Triodia spp.) for improved ecological restoration in arid Australia. This project will investigate composition and functioning of the iconic spinifex grasslands of arid Australia. The findings will increase the capacity to restore these landscapes after mining. Project outcomes directly address the national priority for sustainable use of Australia’s biodiversity, particularly of vulnerable ecosystems.
Uncovering vertebrate lifespan biodiversity with whole genome sequencing. This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. Th ....Uncovering vertebrate lifespan biodiversity with whole genome sequencing. This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. This will provide significant benefits, such as long-term implications for aging research, with possible business applications. It will also increase Australia’s visibility and competitiveness in the developing field of bioinformatics.Read moreRead less