Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the freque ....Revealing the determinants of viral emergence and evolution in fish. Viral diseases pose an ongoing threat to Australian aquaculture. The devastating impact of emerging viruses makes it imperative to understand the factors that allow them to evolve and infect new hosts. We will address these key issues by revealing the diversity, abundance and evolution of viruses in fish sampled along the Australian east coast. The data generated will reveal the untapped biodiversity of fish viruses, the frequency which they jump species boundaries and the determinants of this process, and how they are impacted by host ecology, including whether fish viruses follow a latitudinal gradient in diversity. The data generated will transform our understanding of fish viruses and identify those most likely to impact aquaculture.Read moreRead less
Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters ....Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters and possibly other crustaceans where larval metamorphosis and the juvenile transformation are uncoupled. Using a unique supply of cultured lobsters and advanced molecular techniques, the project aims to develop tools to trigger and synchronise metamorphosis for use in aquaculture and invasive species management.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100225
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Western Australia single-cell isolation and genomics preparation facility. This project aims to give Western Australian researchers direct access to new platforms in single-cell isolation and single-cell RNA, genome and exome sample library preparation, so they can participate in the precision single-cell based research driving biology worldwide. This project will give researchers access to single-cell analysis techniques, integrated with other analysis methods, microscopy, and preclinical imagi ....Western Australia single-cell isolation and genomics preparation facility. This project aims to give Western Australian researchers direct access to new platforms in single-cell isolation and single-cell RNA, genome and exome sample library preparation, so they can participate in the precision single-cell based research driving biology worldwide. This project will give researchers access to single-cell analysis techniques, integrated with other analysis methods, microscopy, and preclinical imaging. The characterisation of rare and complex biological samples is expected to advance effective, socio-economically important research programmes in cell and molecular biology, sports science, plant and crop sciences, agriculture, clean energy (biofuels) resources and production, greenhouse gas reduction, environmental microbiology and marine science.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101141
Funder
Australian Research Council
Funding Amount
$366,000.00
Summary
Critical regions and network connectivity of coral reef ecosystems. This project aims to measure the degree of connectivity between isolated reefs in Australia's Coral Sea and the Great Barrier Reef and identify the biological and environmental mechanisms that enhance management strategies or mitigate against disturbances. The movement of individuals in fragmented landscapes plays a central role in the ecology and evolution of species. The project seeks to measure connectivity at multiple scales ....Critical regions and network connectivity of coral reef ecosystems. This project aims to measure the degree of connectivity between isolated reefs in Australia's Coral Sea and the Great Barrier Reef and identify the biological and environmental mechanisms that enhance management strategies or mitigate against disturbances. The movement of individuals in fragmented landscapes plays a central role in the ecology and evolution of species. The project seeks to measure connectivity at multiple scales and identify critical regions for the design of networks of marine protected areas. This is anticipated to improve our understanding of connectivity in marine seascapes and benefit management of important fishery species and current efforts in coral reef conservation.Read moreRead less
Glauconite: Archive Recording Timing and Triggers of Cambrian Radiation . This project aims to constrain the timing and speed of the Cambrian radiation of complex animals, and to test potential environmental triggers of this milestone bioevent. New laser mass spectrometry and mineral mapping technology will be integrated to precisely date glauconite – a silicate mineral commonly formed in Cambrian shallow marine animal habitats. This innovative and cost-effective approach will produce the first ....Glauconite: Archive Recording Timing and Triggers of Cambrian Radiation . This project aims to constrain the timing and speed of the Cambrian radiation of complex animals, and to test potential environmental triggers of this milestone bioevent. New laser mass spectrometry and mineral mapping technology will be integrated to precisely date glauconite – a silicate mineral commonly formed in Cambrian shallow marine animal habitats. This innovative and cost-effective approach will produce the first high-resolution timeline of early animal evolution, where the glauconite-based marine isotope record identifies the most likely environmental trigger for the Cambrian Radiation. Outcomes of this study include improved understanding of the drivers of animal evolution, and a new dating tool for basic and applied research.Read moreRead less
The rise of algae and the emergence of animals. This project aims to uncover the environmental changes that transformed the oceans 650 million years ago when complex algal cells started to replace bacteria as the dominant forms of life. Using a groundbreaking combination of molecular fossils and isotopes from ancient sedimentary rocks, the project aims to reveal how the flow of energy changed through Earth’s ecosystems. The expected outcomes include new knowledge about our own origins and the ev ....The rise of algae and the emergence of animals. This project aims to uncover the environmental changes that transformed the oceans 650 million years ago when complex algal cells started to replace bacteria as the dominant forms of life. Using a groundbreaking combination of molecular fossils and isotopes from ancient sedimentary rocks, the project aims to reveal how the flow of energy changed through Earth’s ecosystems. The expected outcomes include new knowledge about our own origins and the events that led to the emergence of the first animals. Additionally, new insights about the mechanisms that generated the oldest hydrocarbon reserves may lead to a new biomarker tool to aid discovery of major new oil or gas reserves in Australia’s Red Centre.Read moreRead less
Molecular traces of our primordial ancestors. This project aims to work with the exploration industry to develop an age-diagnostic fingerprinting tool for ancient petroleum seeps. Primordial molecules extracted from 1.6 billion years old rocks are the first and only witnesses of this extinct world. Australia’s vast red centre retains undiscovered oil reserves. This project will yield information about an oil’s provenance and help predict where reserves may be hidden, increasing the accuracy of s ....Molecular traces of our primordial ancestors. This project aims to work with the exploration industry to develop an age-diagnostic fingerprinting tool for ancient petroleum seeps. Primordial molecules extracted from 1.6 billion years old rocks are the first and only witnesses of this extinct world. Australia’s vast red centre retains undiscovered oil reserves. This project will yield information about an oil’s provenance and help predict where reserves may be hidden, increasing the accuracy of surveys and reducing costs and risks of exploration. Broader benefits from the findings may change common understanding about our very earliest ancestors and their effect on the planet’s evolution.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100086
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
A Single-Molecule Super-Resolution Microscopy Facility in Western Australia. A single-molecule super-resolution microscopy facility in Western Australia:
The project aims to establish a facility combining single-molecule imaging with super-resolution microscopy to enable biologists in Western Australia to resolve and directly observe interacting macromolecules in plants, animals and organisms, Interacting macromolecules form the basis of cell biology. Imaging and characterising such interaction ....A Single-Molecule Super-Resolution Microscopy Facility in Western Australia. A single-molecule super-resolution microscopy facility in Western Australia:
The project aims to establish a facility combining single-molecule imaging with super-resolution microscopy to enable biologists in Western Australia to resolve and directly observe interacting macromolecules in plants, animals and organisms, Interacting macromolecules form the basis of cell biology. Imaging and characterising such interactions in living cells and tissues has become possible with the latest molecular imaging techniques and super-resolution optical microscopy (with spatial resolutions of 20 nanometres or better). The facility seeks to advance science across diverse regional priorities in agriculture, environment, marine ecology, medicine and health.Read moreRead less
Can consistent individual differences in metabolic rate explain animal personality? Implications for fish and aquaculture in a warming climate. This project will determine if consistent individual differences in metabolic rate affect behaviour, growth, and reproduction in fish. If so, then we need to prepare for the fact that a warming climate will lead to reductions in fish growth and reproduction, because rising temperature directly increases metabolism and therefore maintenance costs.
Pilot-scale production of therapeutically-active cannabinoids . The Isolation of minor therapeutically-active cannabinoids from cannabis at pilot scale would establish a commercially competitive Australian industry and lead to a superior position in the global marketplace. This project aims to select elite clones from genetically diverse cannabis strains for yield of minor, but therapeutically-active, cannabinoids, and develop a pilot-scale extraction and separation procedure that can be scaled- ....Pilot-scale production of therapeutically-active cannabinoids . The Isolation of minor therapeutically-active cannabinoids from cannabis at pilot scale would establish a commercially competitive Australian industry and lead to a superior position in the global marketplace. This project aims to select elite clones from genetically diverse cannabis strains for yield of minor, but therapeutically-active, cannabinoids, and develop a pilot-scale extraction and separation procedure that can be scaled-up for commercial production. This would contribute to the growth of the agri-biotechnology sector and a skilled multidisciplinary workforce in rural Australia, thus providing significant economic benefit. The novel scale-up procedure has potential for industry adoption to add value to Australian manufacturing.
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