High Resolution Mapping Of Genomic Regions Implicated In Migraine
Funder
National Health and Medical Research Council
Funding Amount
$392,545.00
Summary
Migraine is a frequent, debilitating and painful disorder that affects a significant proportion of the population. Using the diagnostic criteria of the international Headache Society, the prevalence of migraine has been estimated to be approximately 12%, with a recent study in the United States showing that migraine affects 4% of children, 6% of men and 18% of women. The aetiology of migraine is unknown and there are no laboratory based diagnostic tests to identify those who suffer from the diso ....Migraine is a frequent, debilitating and painful disorder that affects a significant proportion of the population. Using the diagnostic criteria of the international Headache Society, the prevalence of migraine has been estimated to be approximately 12%, with a recent study in the United States showing that migraine affects 4% of children, 6% of men and 18% of women. The aetiology of migraine is unknown and there are no laboratory based diagnostic tests to identify those who suffer from the disorder. Clinical diagnosis is currently based on patient symptom descriptions, with individual symptoms being shown to vary with age. Migraine is believed to have a genetic basis with specific environmental factors, such as particular foods, hormonal levels and fatigue, being capable of inducing attacks in predisposed individuals. Migraine shows strong familial aggregation with about 50% of those affected, having another close relative also affected with the disorder. At present the number of genes involved in the disorder is unknown and have not been identified. Recent studies in our laboratory have localised two migraine genes, one to chromosome 19 and the other to the X chromosome. More recently we have also found evidence for a third gene on chromosome 1. This study is aimed at fine scale mapping analysis of these three chromosomal regions in order to pinpoint the location of migraine genes. Our ultimate aim is to identify the molecular causes of this disorder. This would have important implications to both the diagnosis and treatment of migraine.Read moreRead less
Characterisation Of A New Localisation For Susceptibility To Inflammatory Bowel Disease On Chromosome 12
Funder
National Health and Medical Research Council
Funding Amount
$76,125.00
Summary
One of the greatest challenges facing contemporary gastroenterology is to understand the causes of the inflammatory bowel diseases in order to develop more effective therapies. Although there have been advances in treatment over the last few years, the causes of IBD are still not known. The existence of a genetic predisposition to IBD is now well established, and there is strong evidence that the disease is the result of the interaction of a number of different genes. To date, two genetic locali ....One of the greatest challenges facing contemporary gastroenterology is to understand the causes of the inflammatory bowel diseases in order to develop more effective therapies. Although there have been advances in treatment over the last few years, the causes of IBD are still not known. The existence of a genetic predisposition to IBD is now well established, and there is strong evidence that the disease is the result of the interaction of a number of different genes. To date, two genetic localisations (one on chromosome 16 and a second on chromosome 12) have been confirmed in multicentre studies. We have identified a novel localisation for disease susceptibility on chromosome 12 in the Australian population during the course of a genome scan on 73 multiplex inflammatory bowel disease families. (The importance of this localisation has been confirmed in English and American families.) This localisation is quite separate from that originally described and many genes separate the two localisations. We will refine the new localisation by fine scale mapping in the region of the localisation that we originally identified in pure Crohn's disease families. At this stage, the localisation appears not to be important in families suffering from ulcerative colitis or in families in which both CD and UC occurs (known as mixed families), though this finding will be tested. Using state of the art molecular genetics, we will then identify and characterise the gene involved. The significance of this project lies in the importance of this localisation to the understanding of underlying biochemistry and genetics of a complex disease in which multiple genes are segregating and interacting in, some as yet undefined manner.Read moreRead less
The Picturesque in Modernity: object image and architecture. The idea of the picturesque its emergence in the eighteenth century are relatively well known. However, the longer history of the picturesque, through to its use in the present, has not been studied. This Project proposes to describe the key concepts and techniques that constitute the latter history of the picturesque. Against claims that the eighteenth century picturesque was a generic and abstract art, this longer history will show t ....The Picturesque in Modernity: object image and architecture. The idea of the picturesque its emergence in the eighteenth century are relatively well known. However, the longer history of the picturesque, through to its use in the present, has not been studied. This Project proposes to describe the key concepts and techniques that constitute the latter history of the picturesque. Against claims that the eighteenth century picturesque was a generic and abstract art, this longer history will show that the picturesque is better understood as an intra-disciplinary relation of architecture and the visual arts. The Project will be of relevance to issues of the historical status of architecture as an art discipline. At a more general level, the Project will be of significance in present issues in the conceptualization of images and objects, including those that arise in virtual environments, issues which first arose in the picturesque.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100038
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Truth-telling Australia's colonial past with art by non-Indigenous artists. This project aims to address creative practices by non-Indigenous artists that confront Australia's difficult colonial past by advancing best practice approaches for the creation of such artworks. This project expects to generate new knowledge in the area of contemporary art using an innovative approach that combines practice-led, artistic research with interdisciplinary decolonial methodologies. Expected outcomes of thi ....Truth-telling Australia's colonial past with art by non-Indigenous artists. This project aims to address creative practices by non-Indigenous artists that confront Australia's difficult colonial past by advancing best practice approaches for the creation of such artworks. This project expects to generate new knowledge in the area of contemporary art using an innovative approach that combines practice-led, artistic research with interdisciplinary decolonial methodologies. Expected outcomes of this project include improved approaches to how the art sector engages with uncomfortable colonial histories. This should provide significant benefits such as enhanced relations between Indigenous and non-Indigenous people by supporting non-Indigenous artists to engage in sensitive truth-telling about Australia’s colonial past.Read moreRead less
Use Of Expression Profiling To Identify Genes Influencing Cardiovascular Risk In The Norfolk Island Population Isolate
Funder
National Health and Medical Research Council
Funding Amount
$697,409.00
Summary
This study will use a unique population isolate from Norfolk Island. We aim to identify genes that play a role in cardiovascular disease risk. Norfolk has a population of ~1200 permanent residents, most of whom are direct descendents of 18th century English Bounty mutineers and Polynesian women. We will undertake gene expression mapping to identify genomic loci that influence cardiovascular disease using samples from this population isolate.