Solar-Driven C-H Functionalization Reactions. This project aims to investigate the functionalization reaction of unreactive C-H bonds using light as the source of energy. Light is a transformative change to synthesis as thermal activation is exchanged to solar activation. The latter gives access to excited state chemistry and enables reaction steps that are thermally inaccessible. It is a key strategy to leverage synthesis to the demands of the 21st century and to minimise its ecologic footprint ....Solar-Driven C-H Functionalization Reactions. This project aims to investigate the functionalization reaction of unreactive C-H bonds using light as the source of energy. Light is a transformative change to synthesis as thermal activation is exchanged to solar activation. The latter gives access to excited state chemistry and enables reaction steps that are thermally inaccessible. It is a key strategy to leverage synthesis to the demands of the 21st century and to minimise its ecologic footprint. At the same time this strategy provides a lever to profoundly impact and drive new concepts in synthesis. Significant benefits are expected, such as increase in fundamental knowledge on photochemical processes, but also the access to new materials for applications as drugs or OLEDs.Read moreRead less
Integrated nonmetal-metal single-atom catalysis for selective synthesis. Single atom catalysts can achieve the maximum efficiency of active sites for a reaction. This project will develop integrated nonmetal and metal single atom-based catalysts for selective oxidation towards clean production and organic waste conversion to value-added polymers for carbon recycle. The project will result in new functional materials and green catalytic processes for chemical synthesis and waste reduction, and ad ....Integrated nonmetal-metal single-atom catalysis for selective synthesis. Single atom catalysts can achieve the maximum efficiency of active sites for a reaction. This project will develop integrated nonmetal and metal single atom-based catalysts for selective oxidation towards clean production and organic waste conversion to value-added polymers for carbon recycle. The project will result in new functional materials and green catalytic processes for chemical synthesis and waste reduction, and advance fundamental understanding of molecular structure of materials for catalyst design and process engineering for industrial applications. The outcomes will promote the development of chemical industry, waste recycle and green environment in Australia, making significant benefits to economics and society.Read moreRead less
Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less
Mapping the health promoting capacity of art centres on the Anangu Pitjantjatjara Yankunytjatjara Lands. This project will identify the health promoting benefits of art centres managed by Ananguku Arts on the Anangu Pitjantjatjara Yankunytjatjara Lands. The project will identify the social health benefits derived from Art Centres such as increased income, employment opportunities, education, cultural maintenance and community governance.
Identifying the diversity and evolution of loci associated with adaptation to aridity/heat and salinity in ancient cereal crops. This project will use ancient grains of wheat, barley and rye to find 'lost' genetic diversity at key genes associated with resistance to aridity, salt and disease. This project will make the proteins of key genes, and study their interaction with the environment over time by measuring ions in the grains to reveal the ancient environmental conditions.
Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect ....Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect productivity, enhance predictive capability, and initiate advanced breeding strategies to develop new crop varieties with superior resilience against changing climates. This should provide significant benefits, such as profit stability for wheat growers, elevated global market position and improved food security.Read moreRead less
Developing Zn-dense, high-yielding wheat by molecular marker technology. The objective of this project is to identify pathways leading to the accumulation of zinc — an important element for human nutrition — in wheat. The project aims to provide biochemical and molecular markers for breeding programs that will facilitate the selection of superior breeding lines for improved human nutrition and seed health. This project builds on studies using a wheat diversity panel with 90 000 gene-based single ....Developing Zn-dense, high-yielding wheat by molecular marker technology. The objective of this project is to identify pathways leading to the accumulation of zinc — an important element for human nutrition — in wheat. The project aims to provide biochemical and molecular markers for breeding programs that will facilitate the selection of superior breeding lines for improved human nutrition and seed health. This project builds on studies using a wheat diversity panel with 90 000 gene-based single nucleotide polymorphism (SNP) markers, where zinc–SNP associations were identified. The project also builds on recent studies that show particular metabolites and macronutrients around anthesis are linked to improved grain zinc concentration at maturity.Read moreRead less
Understanding the molecular mechanisms of intellectual disability. Intellectual disability is frequent in the population, with one in every fifty people in the world directly affected. This project will improve our understanding of the correct development and function of the brain required for cognition by investigating specific roles and regulation of key molecules involved.
Creative Antarctica: Australian Artists and Writers in the Far South. The project aims to make the rich history of Australian artists' and writers' engagement with Antarctica visible through an innovative combination of critical, curatorial, and qualitative research. It expects to generate new interdisciplinary knowledge of creative responses to the South Polar region. Anticipated outcomes include the first comprehensive history and analysis of the Antarctic stories, sounds, and images produced ....Creative Antarctica: Australian Artists and Writers in the Far South. The project aims to make the rich history of Australian artists' and writers' engagement with Antarctica visible through an innovative combination of critical, curatorial, and qualitative research. It expects to generate new interdisciplinary knowledge of creative responses to the South Polar region. Anticipated outcomes include the first comprehensive history and analysis of the Antarctic stories, sounds, and images produced by Australian artists and writers and recommendations for maximising Antarctic residency outcomes. At a time when Antarctica's future is threatened by warming temperatures and geopolitical tensions, the project provides significant benefits in the form of broader and deeper public engagement with the ice continent.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100883
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Palaeo-population genomics: studying adaptation using ancient human DNA. This project aims to apply state-of-the-art population and quantitative genetic techniques to a powerful new database of ancient human genomes - spanning from hunter gatherers and early farmers through to the Middle Ages. This will be used to build the first detailed portrait of human genetic adaptation through time. This record will capture the major socio-cultural transitions in human history, and reveal the genetic and e ....Palaeo-population genomics: studying adaptation using ancient human DNA. This project aims to apply state-of-the-art population and quantitative genetic techniques to a powerful new database of ancient human genomes - spanning from hunter gatherers and early farmers through to the Middle Ages. This will be used to build the first detailed portrait of human genetic adaptation through time. This record will capture the major socio-cultural transitions in human history, and reveal the genetic and environmental drivers that have shaped modern human genetic diversity and pathology.Read moreRead less