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I have discovered particular factors produced by our white blood cells have the ability to shut down or boost protein production in the gut, pancreas and lung. My vision is to harness these to devise new strategies for treatments for infectious and non-infectious diseases (inflammatory bowel disease, diabetes) that have a high burden on our healthcare system.
Systems Immunology Of Antigen Specific T Cells: From Single-cell To Immune Protection
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
T cells are key for establishment of immune protection and object of ongoing research in vaccines and more recently immunotherapy against infections and some cancers. Their dynamics are complex and many mechanisms remain unknown that could be exploited for modern therapies. Here, in a systems approach I will combined single cell technologies, immunology and computational biology to identify the factors that determine the establishment of long term memory cells utilising a unique set of samples.
Defining The Roles Of The Chemotactic Receptor EBI2 For The Regulation Of Leukocyte Migration And The Generation Of Immunity
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The proposed study aims at improving our understanding of the role of the immune cell receptor Epstein-Barr virus-induced gene 2 (EBI2) in guiding the movement of white blood cells during immune responses. The project will investigate the function of EBI2 in the control of infectious diseases and its regulation on human immune cells. These insights have the potential to create new therapeutic approaches to treat human autoimmune and inflammatory diseases and improve vaccine design.
Improving And Evaluating The Health Of Mothers And Babies
Funder
National Health and Medical Research Council
Funding Amount
$320,848.00
Summary
This research program considers new ways to monitor an unborn baby’s health and to provide better care for childbearing women. Several projects will test the unborn baby’s well being. A new study will consider two forms of cooling treatments to help relieve pain following childbirth. Further research involves studies of the genetics of increased blood pressure in pregnant women and a structured way of looking at existing evidence to consider how well it delivers.
Breaking The Intergenerational Cycle Of Obesity Through Nutritional Interventions
Funder
National Health and Medical Research Council
Funding Amount
$477,180.00
Summary
The nutritional environmental experienced by an individual before birth and in early infancy is a critical determinant of their risk of obesity and assocaited metabolic disorders in later life. Over the course of this fellowship, I will focus on defining the nutritional factors which are the key drivers of this metabolic programming. My ultimate aim is to identify nutritional interventions during pregnancy and/or early infancy which can improve the long-term health outcomes of the child and redu
Implementing, Evaluating And Translating Pragmatic Strategies To Prevent Prenatal Alcohol Exposure (PAE), And Treat Fetal Alcohol Spectrum Disorders (FASD)
Funder
National Health and Medical Research Council
Funding Amount
$340,038.00
Summary
Drinking alcohol when pregnant places the unborn child at risk of lifelong brain damage, that we call Fetal Alcohol Spectrum Disorders (FASD). We can prevent FASD by raising awareness of the harms of drinking in pregnancy, and supporting women not to drink. For those with FASD, treatment programs can help reduce learning and behavioural problems. Our research team work with communities and service providers to implement FASD Prevention and Treatment strategies, and raise awareness of FASD.
Progressing Life Course Research In Psychiatric Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$331,674.00
Summary
Mental health and alcohol disorders are major public health problems which cause long-term disabilities, poor health and early mortality. Addressing these problems requires a better understanding of the early factors leading to these disorders. This research program represents a unique opportunity to increase our knowledge of the origins of these disorders and significantly contribute to improved mental health and alcohol prevention policies and programs.