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The role of P2X7 and P2X4 receptor mediated innate phagocytosis in pathogenesis and treatment of neurodegenerative diseases. This project will identify how inherited variation in two proteins of the brain can accelerate the removal of neurones and predispose to a range of neurodegenerative diseases. Knowledge of the biological basis of this finding will allow a search for new compounds which will slow and protect against this form of neurodegeneration.
Investigating the intercellular trafficking of proteins and RNA and its relevance to neurodegenerative diseases. Alzheimer's and prion diseases are neurodegenerative disorders associated with protein misfolding. This project brings together similar features of these diseases using novel cell- and animal-based studies to develop a greater understanding of the molecular basis of these disorders.
Molecular dissection of malaria parasite motility and host-cell invasion across the lifecycle. Malaria parasites move in a unique way, gliding across cell surfaces and infecting host cells using a unique molecular motor. This research aims to understand the molecular mechanics behind parasite movement and use this to develop novel drugs that might throw a spanner in the parasite motor, blocking movement and thereby preventing malaria disease.
Using law and ending domestic violence: Women's voices. Domestic violence severely damages communities across the globe and law is recognised as a key mechanism for prevention and redress. This project aims to undertake a longitudinal study examining how women of diverse backgrounds use law to help them live a life free of violence. It will investigate what influences women's decisions to choose particular legal interventions but not others, and will identify any unintended consequences flowing ....Using law and ending domestic violence: Women's voices. Domestic violence severely damages communities across the globe and law is recognised as a key mechanism for prevention and redress. This project aims to undertake a longitudinal study examining how women of diverse backgrounds use law to help them live a life free of violence. It will investigate what influences women's decisions to choose particular legal interventions but not others, and will identify any unintended consequences flowing from legal engagement. This project aims to highlight what contributes to women’s satisfaction and sense of safety resulting from legal interventions over time, to make an important contribution to community education, policy implementation and law reform, both within Australia and internationally.Read moreRead less
Harnessing non-invasive brain stimulation to improve language function in healthy and pathological ageing. This project will examine how the ability of the ageing brain to process language can be improved by non-invasive brain stimulation. The findings have the potential to reveal new ways to treat language impairments in ageing-associated brain injury and disease.
Herpesvirus entry into mammalian hosts. Herpesviruses infect most mammals and cause much chronic disease. Our poor understanding of their host entry pathways limits infection control. The olfactory neuroepithelium has been identified as a key entry portal for both a murid herpesvirus and a human pathogen, Herpes simplex virus, suggesting that many herpesviruses use this route. Virions cross the olfactory mucus on neuronal cilia, then either infect neurons or transfer to glial cells for local spr ....Herpesvirus entry into mammalian hosts. Herpesviruses infect most mammals and cause much chronic disease. Our poor understanding of their host entry pathways limits infection control. The olfactory neuroepithelium has been identified as a key entry portal for both a murid herpesvirus and a human pathogen, Herpes simplex virus, suggesting that many herpesviruses use this route. Virions cross the olfactory mucus on neuronal cilia, then either infect neurons or transfer to glial cells for local spread. This project will identify key receptor interactions and map the extent of invasion. By advancing our basic understanding of these important viruses and their uptake at an abundantly exposed but little explored anatomical site, the project can establish a basis for vaccinating against chronic disease.Read moreRead less
Getting an Early Start to aspirations: Understanding how to promote educational futures in early childhood. Children from low socio-economic status (LSES) backgrounds are three times less likely to attend university than their high socio-economic status peers. For families without experience of higher education it is difficult to know how to encourage young children's aspiration for educational futures. This project aims to improve aspirations for educational futures in LSES early childhood sett ....Getting an Early Start to aspirations: Understanding how to promote educational futures in early childhood. Children from low socio-economic status (LSES) backgrounds are three times less likely to attend university than their high socio-economic status peers. For families without experience of higher education it is difficult to know how to encourage young children's aspiration for educational futures. This project aims to improve aspirations for educational futures in LSES early childhood settings. A social marketing intervention targeting parents, children and early childhood educators will be developed and longitudinal interviews will be conducted to understand the development of aspirations by LSES families with young children. The project will produce a unique 'education promotion' strategy for early childhood.Read moreRead less
Safeguarding Australia against vector-borne disease bio-incursions. Traditional diagnostic tests limited by their accuracy and ability to detect more than a few pathogens at one time, presents a major hurdle to protecting Australia's companion animals from a plethora of exotic and emerging vector-borne diseases (VBD). Many of these diseases also pose a major risk to public health. This project aims to develop, validate and verify a highly accurate, cost-effective, portable metabarcoding diagnost ....Safeguarding Australia against vector-borne disease bio-incursions. Traditional diagnostic tests limited by their accuracy and ability to detect more than a few pathogens at one time, presents a major hurdle to protecting Australia's companion animals from a plethora of exotic and emerging vector-borne diseases (VBD). Many of these diseases also pose a major risk to public health. This project aims to develop, validate and verify a highly accurate, cost-effective, portable metabarcoding diagnostic test capable of detecting known, emerging and novel parasitic, bacterial and viral VBD pathogens simultaneously, from clinical samples. The assay will represent a potential paradigm shift in the way VBD are tested, for the purpose of safeguarding Australia against VBD bio-incursions.Read moreRead less
Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less
Understanding the contribution of neuroinflammation in acute and chronic neural injury. A major focus of this project will be investigating the involvement of neuroinflammation in neural cell damage. It will explore how neuroinflammation contributes to this damage in both acute and chronic neuropathologies.