Epidemiology Of Unexplained Antepartum Fetal Death In Australia
Funder
National Health and Medical Research Council
Funding Amount
$450,350.00
Summary
The death of a baby before birth is a devastating event for the parents and families. In the vast number of these deaths, no cause can be found leaving no clues for parents and care providers struggling with decisions about future pregnancies and how the risk may be reduced for all women in pregnancy. Fetal death before the onset of labour without an apparent cause (Unexplained Antepartum Fetal Death (UAFD) constitutes the most common cause of fetal death. In Australia, the rate of UAFD is appro ....The death of a baby before birth is a devastating event for the parents and families. In the vast number of these deaths, no cause can be found leaving no clues for parents and care providers struggling with decisions about future pregnancies and how the risk may be reduced for all women in pregnancy. Fetal death before the onset of labour without an apparent cause (Unexplained Antepartum Fetal Death (UAFD) constitutes the most common cause of fetal death. In Australia, the rate of UAFD is approximately 2 per 1 000 births, contributing 30% to all fetal deaths. The rate of UAFD is over three times the current rate of Sudden Infant Death Syndrome (SIDS) in Australia. Despite this, little research has been undertaken in this area. The research which has been undertaken suggests that factors which are present during pregnancy may identify women who are at risk. However, the results of these studies are not consistent, largely due to the problems with study design, and therefore the available information is not sufficiently reliable to assist in identification of women at risk. Well designed, large scale studies are urgently needed to determine, from the reported list of risk factors, those factors which truly identify a woman at increased risk in the antenatal period where appropriate care can be provided to decrease the likelihood of fetal death. Recently, a collaborative effort involving clinicians and consumers in Australia has commenced to support and undertake research and related activities and to collaborate with international groups in reducing the risk of UAFD (ANZ Fetal Death Collaborative Group). This study forms the basis for this work within Australia. This study is designed to identify women who are at risk of unexplained antepartum fetal death. The study involves a review of 800 unexplained antepartum fetal deaths in three States of Australia and an analysis of information on all births in Australia which is routinely collected by Health Departments.Read moreRead less
Interfacing Epidemiology With Systems Biology For Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$687,975.00
Summary
Over recent time, allergic and some autoimmune diseases have increased among modern children. The change has been too rapid to be due to genetic factors alone and my research program examines also the role of the changing environment. It also examines the health effects of new man-made exposures like plastic product chemicals.
The Burden Of Cancer - Prevention, Treatments, Costs, And Related Diseases
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
This research aims to increase knowledge on the development, optimal treatment, and costs of cancer and the associated risk factors, by applying advanced disease burden measures to comprehensive data gathered from several established and novel databases. This knowledge is important in advancing our understanding of those most vulnerable to cancer and in developing appropriate preventive strategies and health care for those at highest risk.
Recent Changes In IVF Clinical Practice: Data Linkage To Investigate Their Impact On Fetal Growth And Birth Defects.
Funder
National Health and Medical Research Council
Funding Amount
$219,076.00
Summary
In Australia 1 in 25 births are conceived from IVF treatment and this is increasing with the continuing trend towards later childbearing. This study will use linked population data to assess fetal growth and birth defects in IVF-conceived children following major changes to IVF practice in the last decade. There are limited data internationally on health outcomes following the use of more recent IVF techniques and insufficient data to allow for adequate pre-treatment counselling.
A Record Linkage Study Of The Relationship Between Intra-uterine Growth, Birth Weight And Childhood Acute Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$126,000.00
Summary
Little is known about the causes of childhood leukaemia and cancer, and this has been the subject of intense study over many years. Acute Lymphoblastic Leukaemia (ALL) and Acute Myeloid Leukaemia (AML) are the most common types of childhood cancers. The early age of onset of diagnosis of cancer-leukaemia in childhood has focused attention on factors related to pregnancy. Many studies have investigated the relationship between birth weight and risk of leukaemia. Some studies have reported finding ....Little is known about the causes of childhood leukaemia and cancer, and this has been the subject of intense study over many years. Acute Lymphoblastic Leukaemia (ALL) and Acute Myeloid Leukaemia (AML) are the most common types of childhood cancers. The early age of onset of diagnosis of cancer-leukaemia in childhood has focused attention on factors related to pregnancy. Many studies have investigated the relationship between birth weight and risk of leukaemia. Some studies have reported finding an increasing risk of Acute Lymphoblastic Leukaemia with increasing birth weight, but not all studies have reported this relationship. The relationship between birth weight and Acute Myeloid Leukaemia has been even less well described. Many previous studies have not taken account of important factors when analysing the results. This study will use an existing pool of routinely recorded health information, thus ensuring accurate information on birth weight and factors such as maternal height and age and the length of the pregnancy. We will also have complete and accurate information on childhood cancer in Western Australia. Our results will contribute to knowledge about the causes of childhood leukaemia and the biological pathways involved in its development. If growth-related factors do prove to be integrally involved in the aetiology of childhood leukaemia, then the rapidly increasing prevalence of juvenile diabetes, overweight and obesity in Australia and other developed countries could have even more serious implications for the health of our children. It is important that we investigate this question as soon as possible.Read moreRead less