Birth Weight, Adult Weight And Podocyte Depletion.
Funder
National Health and Medical Research Council
Funding Amount
$796,252.00
Summary
A major role of our kidneys is to filter our blood. A key cell type in our kidney filters is an octopus-shaped cell known as the podocyte. If we are not born with enough podocytes, or if the filters grow too large after birth due for example to excessive weight gain, the podocytes cannot adequately filter the blood, and this can lead to kidney disease. We will measure podocyte endowment at birth, and assess the effects of weight gain and loss after birth on podocyte features and kidney health.
The Transmission Of Perinatal Maternal Mental Health To Preschool Emotional Disorders: Examining Pathways And Intervention Points In The MPEWS Study
Funder
National Health and Medical Research Council
Funding Amount
$970,795.00
Summary
While it is known that depression, anxiety and stress in pregnancy increase the risk for poorer child mental health, what is unknown is the key pathways and intervention points to prevent this transmission of risk. This study will examine potential mechanisms and intervention points through a selected cohort study: Mercy Pregnancy and Emotional Wellbeing Study. This study follows 500 women and their children from first trimester in pregnancy until the children are 3 years of age.
Discovery Early Career Researcher Award - Grant ID: DE170101081
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis t ....Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis to efficiently and precisely analyse large-scale programs according to clients’ needs, thereby allowing compilers to generate safe, reliable and secure code. This project is expected to advance value-flow analysis for industrial-sized software, improve software reliability and security, and benefit Australian software systems and industries.Read moreRead less
Design and Formal Verification of Control and Data Acquisition Protocols. This research will develop new specification and verification techniques for remote control protocols, used among interconnected sites in supply utilities such as electricity grids, based on a proven formal methods technology. These protocols are used in the monitoring of data from remote sites, and the transmission of control commands to such sites from a central location. Benefits to the industrial partner include increa ....Design and Formal Verification of Control and Data Acquisition Protocols. This research will develop new specification and verification techniques for remote control protocols, used among interconnected sites in supply utilities such as electricity grids, based on a proven formal methods technology. These protocols are used in the monitoring of data from remote sites, and the transmission of control commands to such sites from a central location. Benefits to the industrial partner include increased assurance that their control technology does correctly realise the adopted protocols. Assurance of correctness is significant in that incorrect protocol implementation may cause errant operation of equipment, and lead to economic and environmental damage.Read moreRead less
Reducing The Effects Of Antenatal Alcohol On Child Health (REAACH)
Funder
National Health and Medical Research Council
Funding Amount
$2,497,397.00
Summary
Use of alcohol in pregnancy can affect the developing baby and cause Fetal Alcohol Spectrum Disorders (FASD). Children with FASD have lifelong brain injury that can lead to poor school performance, poor mental health and trouble with the law. This CRE builds on our strong background in research and community engagement to improve FASD prevention, diagnosis and treatment across Australia.
Recent Changes In IVF Clinical Practice: Data Linkage To Investigate Their Impact On Fetal Growth And Birth Defects.
Funder
National Health and Medical Research Council
Funding Amount
$219,076.00
Summary
In Australia 1 in 25 births are conceived from IVF treatment and this is increasing with the continuing trend towards later childbearing. This study will use linked population data to assess fetal growth and birth defects in IVF-conceived children following major changes to IVF practice in the last decade. There are limited data internationally on health outcomes following the use of more recent IVF techniques and insufficient data to allow for adequate pre-treatment counselling.
Analysis of two-phase effects in sloshing of liquids in marine tanks. One of the winners in the current greenhouse debate is natural gas, and the global market will see the need for transporting large volumes of LNG. Australia's North West Shelf is one of the largest offshore gas reserves in the world. The gas market is one of the biggest contributors for the country's economy. Australia leads the world in the use of tankers for transport of Liquefied Natural Gas (LNG). However, consistent re ....Analysis of two-phase effects in sloshing of liquids in marine tanks. One of the winners in the current greenhouse debate is natural gas, and the global market will see the need for transporting large volumes of LNG. Australia's North West Shelf is one of the largest offshore gas reserves in the world. The gas market is one of the biggest contributors for the country's economy. Australia leads the world in the use of tankers for transport of Liquefied Natural Gas (LNG). However, consistent research in LNG is lacking. This research is a fundamental inquiry into the physics of liquid sloshing and the importance of two-phase effects on sloshing. The research can provide answers that ensure safe operation and transport of LNG from Australia.Read moreRead less
Formal Specification and Realisation of Dynamic Reconfiguration in FPGA-based Systems. The project aims are:
to significantly advance our understanding of the key concepts needed to successfully exploit dynamic, run-time reconfigurable computing, a technology that is now becoming increasingly available due to developments in FPGA (Field Progammable Gate Array) devices, and
the development of an innovative high-level programming environment that will include a language, associated design method ....Formal Specification and Realisation of Dynamic Reconfiguration in FPGA-based Systems. The project aims are:
to significantly advance our understanding of the key concepts needed to successfully exploit dynamic, run-time reconfigurable computing, a technology that is now becoming increasingly available due to developments in FPGA (Field Progammable Gate Array) devices, and
the development of an innovative high-level programming environment that will include a language, associated design methodologies, compilation techniques, and run-time support that will make dynamic reconfigurable computing accessible to a wide community of potential users.
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Novel Bioinformatics approaches for genetics and data linkage. The research project will involve creation of novel data and communications formats to fulfil the vital task of integrating the vast heterogeneous biological resources available. We will apply this new infrastructure to a large data linkage project. In parallel, we will undertake methodological research in informatics to design high throughput research methods and tools to analyse and visualise genetic data. These will be applied to ....Novel Bioinformatics approaches for genetics and data linkage. The research project will involve creation of novel data and communications formats to fulfil the vital task of integrating the vast heterogeneous biological resources available. We will apply this new infrastructure to a large data linkage project. In parallel, we will undertake methodological research in informatics to design high throughput research methods and tools to analyse and visualise genetic data. These will be applied to linkage disequilibrium mapping and haplotyping in human, animal and plant diseases. Improving informatics integration and designing novel methods and implementations of algorithms will be beneficial to local and international researchers in a range of fields.Read moreRead less
A Genome-wide Search For Genes Underlying The Developmental Origins Of Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,022,552.00
Summary
Epidemic rises in the incidence of many chronic diseases such as obesity, type 2 diabetes, hypertension, coronary artery disease and mental illness have occurred in Australia over the last two decades. Antenatal, early life and childhood factors have been consistently associated with the development of such diseases. We propose to conduct a genome-wide scan in an exceptional longitudinal birth cohort in order to identify the genetic mechanisms linking early life event and adult disease.