Defining Genetic And Epigenetic Variation During Early Development
Funder
National Health and Medical Research Council
Funding Amount
$996,075.00
Summary
We all began life with a set of genes inherited from our parents. However, it's now known that from the time we were in the womb onwards that genes can be turned off and on by the environment or even completely lost or gained. Even what your mother ate or how she behaved while she was pregnant could have influenced your future health. Because people are so different, we are studying the subtle differences between twins to tease out the factors that may influence our genes and our health.
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Intercultural understanding in primary and secondary schools. What facilitates or impedes intercultural understanding in children, adolescents and schools? How can this be addressed? How can we know what makes a difference? This project answers these questions at the individual, school and national level using a novel cultural systems approach and methodological and technological innovations.
Motor Functioning In Young People With Attention Deficit Hyperactivity Disorder – Combined Type: A Three-dimensional Motion Analysis Study.
Funder
National Health and Medical Research Council
Funding Amount
$477,065.00
Summary
Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with AD ....Attention deficit hyperactivity disorder –combined type (ADHD-CT) is a complex neuropsychiatric disorder with a progressively devastating impact on psychosocial development. The first objective of this study is to use 3D-motion analysis to ‘probe’ the underlying brain dysfunction which characterises ADHD-CT. The second objective of this study is to improve our understanding of the link between movement problems, and (a) injury proneness, and (b) social-communicative problems, in children with ADHD-CT.Read moreRead less
Taming the intruders: the domestication of Tigger transposable elements in mammals. It has become apparent that most of the DNA that makes us what we are is actually comprised of the remnants of invading parasitic DNA acquired over time. A continual battle exists between host which tries to silence or remove this DNA, and the parasite that tries to multiply and spread. We are currently investigating an intriguing aspect of this process that involves host genomes 'domesticating' parasitic DNA to ....Taming the intruders: the domestication of Tigger transposable elements in mammals. It has become apparent that most of the DNA that makes us what we are is actually comprised of the remnants of invading parasitic DNA acquired over time. A continual battle exists between host which tries to silence or remove this DNA, and the parasite that tries to multiply and spread. We are currently investigating an intriguing aspect of this process that involves host genomes 'domesticating' parasitic DNA to provide novel functions, thereby facilitating the evolution of specific characteristics within species.Read moreRead less
Regional Australia' skills shortages and high-skill refugees' employment . Regional Australia loses to cities thousands of professional and trade-related people whose skills cannot be replaced. Focusing on small and medium-size enterprises producing food and beverages, this project aims to determine whether refugee employment (i) is a strategic resource (ii) can alleviate these chronic regional skill shortages, and (iii) can be integrated in immigration policy. In doing so, it will for the firs ....Regional Australia' skills shortages and high-skill refugees' employment . Regional Australia loses to cities thousands of professional and trade-related people whose skills cannot be replaced. Focusing on small and medium-size enterprises producing food and beverages, this project aims to determine whether refugee employment (i) is a strategic resource (ii) can alleviate these chronic regional skill shortages, and (iii) can be integrated in immigration policy. In doing so, it will for the first time provide critical empirical evidence on the possible need to separate policy measures aimed at rural vs. urban employers. The outcomes will contribute to reducing the problem of critical skill shortages and wastage at once and do so with an eye to the needs to rural Australia – a key driver of the country’s exports. Read moreRead less
The Relationship Between Maternal And Infant Dietary Intake Of Fermentable Fibre, Gut Microbiota, Short Chain Fatty Acids And Allergic Disease And Asthma: A Population-derived Birth Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$871,700.00
Summary
The proposed study will involve the Barwon Infant Study (BIS) cohort of 1074 infants to provide the first systematic investigation of the hypotheses that the epidemic of allergic disease and asthma in many parts of the world relates to the paucity of fermentable fibre in the modern diet, and that the protective effect of fermentable fibre is mediated by changes in the organisms that colonise the gut and the metabolites that they produce.
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and po ....More than a Roof Overhead: Meeting the Need for a Sustainable Housing System in Remote Indigenous Communities. Many Indigenous Australians live in substandard and over-crowded accommodation, and experience poor health, education, family stability and child-safety outcomes as a result. The lack of improvement in this situation is largely due to levels of funding and approaches to construction and management inadequate to the scale of the problem. This situation is changing and new funding and policies are being established. The researchers will work alongside housing providers and selected Indigenous communities in Western Australia and Northern Territory to develop procurement, construction and housing management practices that will meet the critical need for more affordable, appropriate and sustainable housing.Read moreRead less