Applications of probiotics in yoghurt, soy yoghurt and Cheddar cheese. The main goal of this study is to develop probiotic yoghurt and Cheddar cheese using selected strains of probiotic bacteria and examine their survival and effects on proteolysis and sensory attributes of these products. Research aimed at enrichment of suitable probiotic adjunct starter in these products provides the potential to markedly improve both the health status and quality of products. Optimum conditions for survival o ....Applications of probiotics in yoghurt, soy yoghurt and Cheddar cheese. The main goal of this study is to develop probiotic yoghurt and Cheddar cheese using selected strains of probiotic bacteria and examine their survival and effects on proteolysis and sensory attributes of these products. Research aimed at enrichment of suitable probiotic adjunct starter in these products provides the potential to markedly improve both the health status and quality of products. Optimum conditions for survival of probiotic bacteria and processing conditions that guarantee high levels of probiotic bacteria for health benefits will be known. The results will provide critical information for improving survival of probiotic bacteria and quality of probiotic yoghurt, and Cheddar cheese.Read moreRead less
Stability of bioactive isoflavone aglycones and probiotic bacteria in soy based food during processing and storage. The aims of this study are to ascertain the optimum conditions for bioconversion of inactive isoflavone glucosides to bioactive isoflavone aglycones by bifidobacteria and assess the stability of bioactive aglycones during processing and storage. Studies have shown that dietary phytoestrogen an important role in prevention of cardiovascular disease, osteoporosis and breast and prost ....Stability of bioactive isoflavone aglycones and probiotic bacteria in soy based food during processing and storage. The aims of this study are to ascertain the optimum conditions for bioconversion of inactive isoflavone glucosides to bioactive isoflavone aglycones by bifidobacteria and assess the stability of bioactive aglycones during processing and storage. Studies have shown that dietary phytoestrogen an important role in prevention of cardiovascular disease, osteoporosis and breast and prostate cancer (Nagata et al., 1998). Optimum conditions for production of bioactive isoflavones and processing conditions that guarantee high levels of bioactive isoflavones for health benefits will be known. The results will provide critical information for creating market potential for a range of health based functional foods.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453935
Funder
Australian Research Council
Funding Amount
$220,106.00
Summary
Multi-Scale Fermentation Facility for Beverage Research. Australia's largest concentration of beverage fermentation research effort and infrastructure is arguably represented by the University of Adelaide and partners at the Waite Campus, particularly The Australian Wine Research Institute and Provisor Pty Ltd. This cluster seeks to establish an integrated, jointly managed, Multi-Scale Fermentation Facility for Beverage Research. This Facility will address critical shortages in fermentation capa ....Multi-Scale Fermentation Facility for Beverage Research. Australia's largest concentration of beverage fermentation research effort and infrastructure is arguably represented by the University of Adelaide and partners at the Waite Campus, particularly The Australian Wine Research Institute and Provisor Pty Ltd. This cluster seeks to establish an integrated, jointly managed, Multi-Scale Fermentation Facility for Beverage Research. This Facility will address critical shortages in fermentation capacity for research (volumes between 1 ml and 1000 L), offer a vertically integrated system to facilitate step-wise scale-up, allow more accurate modelling of industrial fermentations, enable greater adoption of high-throughput formats and technologies, and achieve enhanced productivity through increased system automation.Read moreRead less
New fermentation and purification production technologies for menaquinone-7 for promoting bone and cardiovascular health. We will develop a significantly more cost-efficient and environmentally friendly process for the production of vitamin K (menaquinone-7, or MK7) to manufacture food supplements for humans and animals. MK7 will increase bone regeneration and minimise the risk of cardiovascular disease. It has the potential to reduce the costs of these conditions for the community, and to incre ....New fermentation and purification production technologies for menaquinone-7 for promoting bone and cardiovascular health. We will develop a significantly more cost-efficient and environmentally friendly process for the production of vitamin K (menaquinone-7, or MK7) to manufacture food supplements for humans and animals. MK7 will increase bone regeneration and minimise the risk of cardiovascular disease. It has the potential to reduce the costs of these conditions for the community, and to increase the quality of life for Australia's ageing population. Orthopaedic diseases are also a major veterinary issue, and our advance should make MK7 a more widely used available supplementary food for animals such as horses and dogs. Read moreRead less
Ex vivo production of neutrophils. Relentless infections frequently occur in patients receiving intensive chemotherapy treatment. Chemotherapy is toxic to the bone marrow where blood cells are produced. A low white blood cell count and in particular a low neutrophil count is linked with infection in these patients. Unlike red cells and platelets, neutrophils are difficult to collect from blood donors and hence are not routinely available. In this project, we will develop a practical, cost effic ....Ex vivo production of neutrophils. Relentless infections frequently occur in patients receiving intensive chemotherapy treatment. Chemotherapy is toxic to the bone marrow where blood cells are produced. A low white blood cell count and in particular a low neutrophil count is linked with infection in these patients. Unlike red cells and platelets, neutrophils are difficult to collect from blood donors and hence are not routinely available. In this project, we will develop a practical, cost efficient process for the production of neutrophils from cord blood. Transfusion of these neutrophils should reduce the chance of patients suffering serious infection, allow them to recover faster from their chemotherapy, and reduce the need for admission to intensive care.Read moreRead less
EX VIVO PRODUCTION OF MATURE RED BLOOD CELLS FOR TRANSFUSION. This project aims to establish a practical, cost efficient biotechnology platform for the expansion and maturation of blood stem cells to produce blood transfusion products. Red blood cell production will be used as the prototype model. It is envisaged that blood bioreactors will initially supplement and ultimately replace the current blood donor based process, thus overcoming the on-going donor recruitment, retention and safety issue ....EX VIVO PRODUCTION OF MATURE RED BLOOD CELLS FOR TRANSFUSION. This project aims to establish a practical, cost efficient biotechnology platform for the expansion and maturation of blood stem cells to produce blood transfusion products. Red blood cell production will be used as the prototype model. It is envisaged that blood bioreactors will initially supplement and ultimately replace the current blood donor based process, thus overcoming the on-going donor recruitment, retention and safety issues associated with collection of single units of blood. This project is focused on providing solutions to two key technical and economical challenges: (a) achieving full maturation of red blood cells and (b) achieving at least a 100-fold intensification of the expansion and maturation process through perfusion.Read moreRead less
The microbiology and biotechnology of rum production. Rum is an alcoholic beverage produced by microbial fermentation of molasses waste from the sugar industry. The microbial species responsible for the process determine rum flavour and quality by production of specific aroma compounds. The rate and extent of fermentation determine process efficiency. Several yeast and bacterial species contribute to rum fermentation but this ecology is poorly defined. Through a combination of ecological stu ....The microbiology and biotechnology of rum production. Rum is an alcoholic beverage produced by microbial fermentation of molasses waste from the sugar industry. The microbial species responsible for the process determine rum flavour and quality by production of specific aroma compounds. The rate and extent of fermentation determine process efficiency. Several yeast and bacterial species contribute to rum fermentation but this ecology is poorly defined. Through a combination of ecological studies, controlled fermentations and distillation, chemical and sensory analyses, this project will determine the impact of particular microbial species on rum flavour and process efficiency. This information will be used by the industrial partner to enchance product quality and process efficiency.Read moreRead less
An Integrated Biotechnological Process for Production of Lactic Acid from Carbohydrate-Waste Streams by Rhizopus sp. Lactic acid is the most widely occurring multifunctional organic acid. It has enormous applications in food and food-related industries, and great potential use for production of biodegradable and biocompatible polylactate polymers. The aim of this research is to develop an innovative biotechnological process, incorporating simultaneous saccharification and fermentation, which int ....An Integrated Biotechnological Process for Production of Lactic Acid from Carbohydrate-Waste Streams by Rhizopus sp. Lactic acid is the most widely occurring multifunctional organic acid. It has enormous applications in food and food-related industries, and great potential use for production of biodegradable and biocompatible polylactate polymers. The aim of this research is to develop an innovative biotechnological process, incorporating simultaneous saccharification and fermentation, which integrates the production of lactic acid with the treatment of high strength food industry ?effluent? streams - carbohydrate waste streams. The proposed SSF process will cultivate an identified fungal Rhizopus sp strain on the waste streams, as production substrates, leading to an environmentally friendly and economically sustainable new technology for the food industry.Read moreRead less
Exploiting novel yeast attributes to produce industrial strains with better fermentative and processing qualities. Food and beverage fermentations are problematic processes, largely due to limitations of the yeast being used. This laboratory has indentified in individual yeast strains highly desirable fermentative characteristics or else the ability to over-produce compounds that benefit product processing. Pursuing the commercial potential of these findings is the specific objective of this pro ....Exploiting novel yeast attributes to produce industrial strains with better fermentative and processing qualities. Food and beverage fermentations are problematic processes, largely due to limitations of the yeast being used. This laboratory has indentified in individual yeast strains highly desirable fermentative characteristics or else the ability to over-produce compounds that benefit product processing. Pursuing the commercial potential of these findings is the specific objective of this proposal. Thus we will extend our collaboration with Coopers Brewery through this new project area with the aims of a) producing optimised, hybrid (non-GMO) strains with combinations of desirable fermentation properties, b) develop novel processing or quality-enhancing treatments while c) generating a high caliber PhD graduate with extensive industry experience.Read moreRead less
Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a t ....Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a trend to move away from the use of antibiotics in food production animals. Current vaccines are based on inactivated preparations and do not offer a high level of immune protection. Therefore, there is a great need worldwide for a live vaccine for the effective control of Glässer's disease.Read moreRead less