Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new know ....Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology. Read moreRead less
New genetic mechanisms linking flowering, growth habit and yield in legumes. This project aims to investigate the genetic control of flowering and flowering-related traits in legumes, an important group of crop plants. The regulation of flowering by environmental factors has a major influence on plant yield and is important for adaptation in natural and agricultural settings. However, it is poorly understood at the molecular level. This project aims to use induced genetic variation and transcrip ....New genetic mechanisms linking flowering, growth habit and yield in legumes. This project aims to investigate the genetic control of flowering and flowering-related traits in legumes, an important group of crop plants. The regulation of flowering by environmental factors has a major influence on plant yield and is important for adaptation in natural and agricultural settings. However, it is poorly understood at the molecular level. This project aims to use induced genetic variation and transcriptome analysis to define new genes and genetic mechanisms through which flowering is regulated by day length and temperature, and to explore the molecular links between flowering and other developmental processes including seed development. This should extend our understanding of how plant architecture, reproduction and yield are regulated by the environment, and address several agronomic issues.Read moreRead less
Genetics, genomics and evolution of flowering time control in legumes. Flowering in plants is strongly regulated by environmental factors, with important consequences for their natural distribution and use in agriculture. This project will characterise genes, genetic diversity and molecular mechanisms that control flowering in legumes, contributing to fundamental biology, crop improvement and research training.
Decoding the signals in legume symbioses: investigating the role of plant hormones. Plants form intimate relationships with soil microbes that give plants access to previously unavailable but essential nutrients. Legumes are major Australian crops for fodder, grain and nutrients, and are unique in forming symbioses with both nitrogen-fixing bacteria and with mycorrhizal fungi that supply nutrients such as phosphate. This project aims to determine the role of plant hormones (small, mobile, potent ....Decoding the signals in legume symbioses: investigating the role of plant hormones. Plants form intimate relationships with soil microbes that give plants access to previously unavailable but essential nutrients. Legumes are major Australian crops for fodder, grain and nutrients, and are unique in forming symbioses with both nitrogen-fixing bacteria and with mycorrhizal fungi that supply nutrients such as phosphate. This project aims to determine the role of plant hormones (small, mobile, potent growth regulators) in the formation of these relationships. In particular, the role of interactions between hormones and other novel plant signals will be determined. An insight into the common and divergent roles of hormones in these symbioses is essential to provide new tools to maximise nutrient acquisition.Read moreRead less
Unique plant hormone responses: the key to nitrogen-fixing nodules. This project aims to build a model of the signals that regulate root nodule formation, unique root organs formed by some plants that host nitrogen-fixing bacteria. Nitrogen is often limited in the soil and agriculture relies on nitrogen fertiliser. Sustainable sources of plant nutrients are required to ensure food security and minimise the environmental impact of intensive farming. This project will provide fundamental informati ....Unique plant hormone responses: the key to nitrogen-fixing nodules. This project aims to build a model of the signals that regulate root nodule formation, unique root organs formed by some plants that host nitrogen-fixing bacteria. Nitrogen is often limited in the soil and agriculture relies on nitrogen fertiliser. Sustainable sources of plant nutrients are required to ensure food security and minimise the environmental impact of intensive farming. This project will provide fundamental information on why some species can form nitrogen-fixing nodules by examining the role of plant hormones. This will build the knowledge base required to potentially expand this symbiosis into non-legumes, harnessing the huge advantage nodule forming species have in staple crops.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100155
Funder
Australian Research Council
Funding Amount
$909,079.00
Summary
Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within livin ....Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within living tissue over long time-scales without inducing phytotoxicity to produce high-impact fundamental and translatable outcomes, the development of novel probes and methodologies, new cross-disciplinary collaborations, and new and unique funding, student training and public engagement opportunities.Read moreRead less
The role of plant hormones in legume symbioses. Soil microbes can give plants access to previously unavailable but essential nutrients through symbioses. Legumes are unique as they form symbioses with both nitrogen-fixing bacteria and with mycorrhizal fungi that supply nutrients such as phosphate. This proposal will investigate the role of the plant hormones (small, mobile, potent growth regulators) in the formation of these symbiotic relationships across legume genera. An insight into the commo ....The role of plant hormones in legume symbioses. Soil microbes can give plants access to previously unavailable but essential nutrients through symbioses. Legumes are unique as they form symbioses with both nitrogen-fixing bacteria and with mycorrhizal fungi that supply nutrients such as phosphate. This proposal will investigate the role of the plant hormones (small, mobile, potent growth regulators) in the formation of these symbiotic relationships across legume genera. An insight into the common and divergent roles of hormones in these symbioses is essential to provide researchers and breeders with new tools to maximise nutrient acquisition by legumes, important crops contributing an estimated one billion Australian dollars per year to the Australian economy.Read moreRead less
Individual, social and physical environmental influences on children's active transport and independent mobility. Childhood obesity is likely to have significant economic and social impacts on Australian society. Preventing further increases in this disease is crucial, particularly among children at high risk such as those living in rural or disadvantaged areas. The promotion of behaviours such as active transport may have a significant benefit for public health; however little is known about wh ....Individual, social and physical environmental influences on children's active transport and independent mobility. Childhood obesity is likely to have significant economic and social impacts on Australian society. Preventing further increases in this disease is crucial, particularly among children at high risk such as those living in rural or disadvantaged areas. The promotion of behaviours such as active transport may have a significant benefit for public health; however little is known about what influences active transport among children in rural or disadvantaged areas. This study will identify important factors influencing active transport and will directly inform strategies aiming to promote health and wellbeing, thereby creating a healthier generation of Australian children.Read moreRead less
Epidemiologic and economic approaches to reduce the burden of depression and related chronic diseases in the workforce. Employers and governments alike are increasingly recognising that mental health impacts productivity, but many employers remain uninformed about the magnitude of the productivity consequences and what they can do about it. The ongoing individual and economic burden from depressive and anxiety disorders among working adults necessitates multi-disciplinary solutions. This series ....Epidemiologic and economic approaches to reduce the burden of depression and related chronic diseases in the workforce. Employers and governments alike are increasingly recognising that mental health impacts productivity, but many employers remain uninformed about the magnitude of the productivity consequences and what they can do about it. The ongoing individual and economic burden from depressive and anxiety disorders among working adults necessitates multi-disciplinary solutions. This series of studies will provide nationally and internationally significant new data to both inform understanding of the magnitude of the problem, and to provide cost-effective solutions to addressing it. Findings will directly inform workplace mental health promotion and prevention activities and be usable by employers, clinicians, and governments.Read moreRead less
Critical windows: understanding changes in eating and physical activity over the transition from secondary school to young adulthood. This project will explain changes in eating, physical activity and sedentary behaviour during the critical period of transition from secondary school to young adulthood. It will provide important information on how we can assist adolescents to maintain a healthy lifestyle over a time characterised by several major life changes.