Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health ser ....Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.Read moreRead less
Nanosampling sensors for real-time embryo monitoring. The health potential of every individual is established early in life, during the period when the oocytes mature and embryos are formed. This project will develop a photonic sensing platform capable of monitoring embryos as they develop, which will lead to new insight into the earliest stages of life and improved assisted reproduction technologies.
Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to matu ....Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.Read moreRead less
Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and ....Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and the feminisation process, converted to practical ways to manipulate these important agronomic traits. This will derisk the industrial hemp industry, encouraging increased cultivation of a nutritionally and economically valuable crop in Australia and create valuable intellectual property applicable globally.Read moreRead less
Influences on farmer suicide in Queensland and New South Wales. Australian farmers have been identified as being at high-risk of suicide. This project will provide direction for targeted suicide prevention strategies by quantifying the individual and environmental factors that place farmers at higher risk of suicide, as well as the protective factors that may buffer against suicide and suicidal behaviours.
A randomised controlled trial assessing the effects of a school-based sleep intervention in Year 6 and 7 students. Inadequate sleep is associated with a wide range of health problems in children, including obesity and poor performance at school. Children are sleeping less than ever before, and there is an increasing pattern of “yo yo sleeping” (sleep deprivation on school days followed by catch up sleeps on weekends). This study will trial a school-based program designed to improve the sleeping ....A randomised controlled trial assessing the effects of a school-based sleep intervention in Year 6 and 7 students. Inadequate sleep is associated with a wide range of health problems in children, including obesity and poor performance at school. Children are sleeping less than ever before, and there is an increasing pattern of “yo yo sleeping” (sleep deprivation on school days followed by catch up sleeps on weekends). This study will trial a school-based program designed to improve the sleeping habits of children. Better sleep is expected to result in improved alertness, better life satisfaction, and improved weight status.Read moreRead less
New directions in health inequalities research: understanding the intersection between housing, employment and health in Australia. People employed on a casual basis in Australia are nearly three times more likely to live in a household that is in housing affordability stress than their permanently employed counterparts. Employment and housing are both determinants of health. While social inclusion, employment and housing affordability are critical components of the government's current social p ....New directions in health inequalities research: understanding the intersection between housing, employment and health in Australia. People employed on a casual basis in Australia are nearly three times more likely to live in a household that is in housing affordability stress than their permanently employed counterparts. Employment and housing are both determinants of health. While social inclusion, employment and housing affordability are critical components of the government's current social policy agenda, articulation between these policy domains is limited and little researched. This important study will provide robust evidence on the ways that housing and employment interact to both cause and prevent health inequities. This will directly benefit agencies delivering services to vulnerable people and contribute to an evidence base of benefit to policy makers.Read moreRead less
A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic ev ....A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic evaluation, improving the quality of life and wellbeing of older Australians, and will assist in determining the relative cost effectiveness of new and existing services.
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Caring for the carers: occupational health and safety in homecare. Homecare workers care for vulnerable clients but their own vulnerability to health and safety risks is seldom examined. Pilot research revealed unrecognised hazards arising from the isolated and fragmented nature of the work. This project will systematically identify hazards and develop interventions to promote healthier and safer homecare work.
Adaptive capabilities in the elderly during extreme heat events in South Australia. This study, using first hand accounts of experiences and perceptions of the extreme heat event of 2009 in South Australia, will provide a valuable insight into the heat adaptive capability of the ageing population, factors affecting susceptibility, and ways to curb the predicted increase in often life-threatening heat exacerbated illnesses, many of which require extended hospital stays. It is envisaged that findi ....Adaptive capabilities in the elderly during extreme heat events in South Australia. This study, using first hand accounts of experiences and perceptions of the extreme heat event of 2009 in South Australia, will provide a valuable insight into the heat adaptive capability of the ageing population, factors affecting susceptibility, and ways to curb the predicted increase in often life-threatening heat exacerbated illnesses, many of which require extended hospital stays. It is envisaged that findings will help inform health policy and contribute to the formulation of a National Heatwave Response plan. Study findings will be disseminated widely at government (state and federal), non-government, and community levels and will help to raise the awareness of heat exacerbated illness in general.Read moreRead less