Fear Relapse: Neural Substrates Underlying Its Inhibition And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$437,476.00
Summary
Exposure-based therapies are effective for anxiety disorders such as post traumatic stress, but two challenges remain: 1) patients that have learned to inhibit their fear are likely to relapse, requiring further therapy; 2) many drop out of therapy since it is aversive and anxiety provoking. We use an animal model to: 1) identify the neural substrates underlying fear inhibition; and 2) determine the conditions that prevent relapse and encourage participation in treatment.
The Effect Of Oxytocin On The Formation, Expression And Inhibition Of Fear Memories
Funder
National Health and Medical Research Council
Funding Amount
$390,243.00
Summary
Oxytocin is a hormone peptide which reduces amygdala activation to threatening stimuli and reduces anxiety in people and laboratory rodents. These results suggest that oxytocin could be a valuable pharmacological adjunct to exposure-based therapy for anxiety disorders. However, several questions must be answered before its therapeutic potential can be determined. As such, this project examines the effects of oxytocin on fear-related behaviours in rats, and neural fear circuits in the amygdala.
The Extinction Of Conditioned Fear And Its Implications For Cue Exposure Therapy
Funder
National Health and Medical Research Council
Funding Amount
$322,430.00
Summary
This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavl ....This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavlovian conditioning, subjects (typically rats) are exposed to a signaling relation between an initially neutral stimulus (e.g., a noise) and a feared outcome (e.g., foot shock). When later repeatedly exposed to the initially neutral but now feared stimulus (the noise) in the absence of the feared outcome, the fear reactions it acquired progressively decline until eventually it fails to elicit any such reactions. The fear reactions are said to have been extinguished. There has been significant progress in understanding the psychological processes and neural mechanisms underlying the acquisition of fear reactions, but much less is known about the processes and mechanisms underlying the extinction of these reactions. The project has two general objectives. The first is to determine the conditions of extinction training that promote long-term loss of fear reactions. The second objective is to determine how the brain controls this extinction of learned fear. Achieving these aims will be significant for two reasons. First, it will contribute to understanding the mechanisms by which animals (including people) learn to adjust their behaviour to bring it into line with the current relations that exist between events in the world. Second, it will provide important information about how such adjustment is facilitated or impaired across extinction training and, thereby, contribute towards understanding both the successes and failures of cue exposure therapy for fear-related disorders.Read moreRead less
Increased Vulnerability To Stress During Opiate Dependence: Molecular, Anatomical, And Behavioural Correlates
Funder
National Health and Medical Research Council
Funding Amount
$272,640.00
Summary
Heroin addiction is a major health and societal problem in Australia. It is consistently associated with an adverse impact upon individual users, their families, and communities. It is a chronically relapsing condition for which few, if any effective prevention and treatment strategies exist. Moreover, why an individual initiates and maintains heroin taking remains unclear. Stress and negative emotions have a strong impact on heroin use. Stress may drive some individuals to start using heroin, s ....Heroin addiction is a major health and societal problem in Australia. It is consistently associated with an adverse impact upon individual users, their families, and communities. It is a chronically relapsing condition for which few, if any effective prevention and treatment strategies exist. Moreover, why an individual initiates and maintains heroin taking remains unclear. Stress and negative emotions have a strong impact on heroin use. Stress may drive some individuals to start using heroin, stress increases the pleasurable effects of heroin and stress increases the aversive effects of heroin withdrawal. These effects will encourage addiction and discourage addicts from seeking treatment. Stress can also cause an otherwise drug-free individual to relapse to heroin addiction despite having been drug-free for some time. In this project we will study why stress has such a large impact on heroin addicts and heroin addiction. We will test the hypothesis that heroin use actually produces profound alterations in the neural network in the brain which controls responses to stress. This project uses a simple animal model of heroin addiction whereby rats are injected with morphine to study the regulation of several genes which are important in responding to stress. We will also study how this exposure and changes in gene expression alter neurobiological, cardiovascular, and behavioural responses to stress. This project will identify parts of the brain that are altered during heroin addiction, and will also identify why heroin addicts are more vulnerable to stress than the general population. Therefore, this project will help us to identify targets for therapeutic intervention (both psychological and pharmacological) and possibly disrupt the addictive cycle.Read moreRead less
Science and the Shaping of Modernity, 1690-1755. It is important that we understand the values underlying our culture, and one form of such understanding is historical. The idea that science provides the standards for all forms of cognitive enquiry is an intrinsic part of modern culture, and the notions of impartiality and objectivity that it is taken to express are closely tied in with estimations of the value of our culture. The history of how this conception emerged in the early-modern period ....Science and the Shaping of Modernity, 1690-1755. It is important that we understand the values underlying our culture, and one form of such understanding is historical. The idea that science provides the standards for all forms of cognitive enquiry is an intrinsic part of modern culture, and the notions of impartiality and objectivity that it is taken to express are closely tied in with estimations of the value of our culture. The history of how this conception emerged in the early-modern period shows that there was nothing self-evident in the assimilation of cognitive values to scientific ones, however, or in the extrapolation of these to general cultural and political values. Read moreRead less
The persona of the philosopher in early modern Europe. The project aims to provide a new interpretation of the history of early modern European philosophy, organised around the key concept of the persona of the philosopher. By focusing on the shaping and reshaping of the philosophical persona - understood as a self cultivated for the purposes of conducting philosophical life and learning - the project will offer novel and fundamental insights into conflicts over the character of philosophy, its ....The persona of the philosopher in early modern Europe. The project aims to provide a new interpretation of the history of early modern European philosophy, organised around the key concept of the persona of the philosopher. By focusing on the shaping and reshaping of the philosophical persona - understood as a self cultivated for the purposes of conducting philosophical life and learning - the project will offer novel and fundamental insights into conflicts over the character of philosophy, its disciplinary borders, its relation to the new scientific enterprises of the era, and its relation to civil and religious life.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less
A history of terra nullius. The concept of 'terra nullius' has been central to debates concerning the land rights of indigenous peoples. The term, however, has been understood almost in an historical vacuum. Partly in consequence, landmark legal rulings supposedly overturning the doctrine of terra nullius have left European colonisers' justifications of their appropriation of land largely conceptually intact. The central innovation of this history will be to show that when terra nullius, prop ....A history of terra nullius. The concept of 'terra nullius' has been central to debates concerning the land rights of indigenous peoples. The term, however, has been understood almost in an historical vacuum. Partly in consequence, landmark legal rulings supposedly overturning the doctrine of terra nullius have left European colonisers' justifications of their appropriation of land largely conceptually intact. The central innovation of this history will be to show that when terra nullius, properly understood, is rejected in order to establish native title, the implications for the European tradition of property rights and human rights more generally will be profound.Read moreRead less
State formation and European expansion. There is a direct national benefit from this research. The aim of an intellectual history of colonisation is to provide an account of what Europeans engaged in expansion understood themselves to be doing. This account explores the justifications and political motivations for expansion and is accordingly of fundamental importance to contemporary legal debates over dispossession and the larger legacy of colonisation.
Isaac Newton's Temple of Solomon and his analysis of sacred architecture: An interpretation and discussion of Babson Manuscript 0434. Babson Manuscript is an important Newtonian manuscript that contains significant cross disciplinary ideas. It requires a multi-disciplinary understanding and skills for its detailed evaluation. Interpretation and analysis of this significant Newtonian manuscript will advance Newtonian scholarship and will be a valuable resource for researchers of architectural his ....Isaac Newton's Temple of Solomon and his analysis of sacred architecture: An interpretation and discussion of Babson Manuscript 0434. Babson Manuscript is an important Newtonian manuscript that contains significant cross disciplinary ideas. It requires a multi-disciplinary understanding and skills for its detailed evaluation. Interpretation and analysis of this significant Newtonian manuscript will advance Newtonian scholarship and will be a valuable resource for researchers of architectural history. This project has both academic and public outcomes. Recently there has been an increased interest in what is commonly perceived as 'ancient wisdom.' Solomon's Temple is one of the most revered ancient symbols. This project will make the history and ideas of this symbol more accessible to the publicRead moreRead less