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Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
The online future of Science and Engineering education: The essential elements of laboratory-based learning for remote-access implementation. Laboratory classes are a critical part of science and engineering degree programs, but there has been little research into what actually takes place within them. Remote laboratories, in which students control equipment via the internet, are one potential solution for accommodating rising numbers of students, but the interfaces must be developed to effectiv ....The online future of Science and Engineering education: The essential elements of laboratory-based learning for remote-access implementation. Laboratory classes are a critical part of science and engineering degree programs, but there has been little research into what actually takes place within them. Remote laboratories, in which students control equipment via the internet, are one potential solution for accommodating rising numbers of students, but the interfaces must be developed to effectively support student learning. This project will investigate how students interact with equipment, each other, and with laboratory demonstrators in order to determine the crucial components of effective laboratory learning experiences. It will identify and characterise the interactions of students in laboratory classes, and develop mechanisms to support these interactions remotely.Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Eventful learning in quality pre-service science teacher education. The study aims to build a theory that explains quality in science teacher education by identifying successful learning-teaching events across programs of university science teacher education. This theory will guide wider application of eventful learning practices at university to enhance the successful entry of new teachers to the profession.
Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to pre ....Conservation management of seed-eating birds in the tropical savannas. Biodiversity loss in the savannas indicates unsustainable management. This research will enhance our abilities to effectively manage Australia's tropical savannas, as well as contributing to several State and Territory, Commonwealth and international obligations to maintain biodiversity. Understanding the processes underlying current declines will also make the effects of future management or environment changes easier to predict. Retaining threatened species can benefit remote and regional communities through tourism, and also through the extra employment required to implement the management prescriptions that will be developed from this research.Read moreRead less
A Future Beyond the Wall: Improving Post-release Employment Outcomes for People Leaving Prison. Engaging in meaningful work has been shown to reduce re-offending by ex-prisoners, but few prison releasees internationally or in Australia gain employment, and successful pathways to employment for this group are poorly researched and understood. This study aims to gather and analyse, for the first time, comparative data from Australian jurisdictions and employment agencies on the relationship betwee ....A Future Beyond the Wall: Improving Post-release Employment Outcomes for People Leaving Prison. Engaging in meaningful work has been shown to reduce re-offending by ex-prisoners, but few prison releasees internationally or in Australia gain employment, and successful pathways to employment for this group are poorly researched and understood. This study aims to gather and analyse, for the first time, comparative data from Australian jurisdictions and employment agencies on the relationship between in-prison and post-prison vocational education and employment programs, employment and recidivism. It aims to identify effective elements, strategies, program and policy directions in offender training and employment. This is a unique partnership amongst key academics in the field, peak national bodies, correctional and employment organisations.Read moreRead less
Mammal declines in northern Australia: science for conservation and recovery. Australia’s unique mammal fauna is a rich biological heritage for the nation. It provides a wealth of ecosystem services, and many mammal species have special cultural or aesthetic value. However, our mammals are sadly depleted, and we already have the worst record of recent mammal extinction of any nation. Preventing further mammal extinctions, and managing environments to allow declined mammals to recover, will be of ....Mammal declines in northern Australia: science for conservation and recovery. Australia’s unique mammal fauna is a rich biological heritage for the nation. It provides a wealth of ecosystem services, and many mammal species have special cultural or aesthetic value. However, our mammals are sadly depleted, and we already have the worst record of recent mammal extinction of any nation. Preventing further mammal extinctions, and managing environments to allow declined mammals to recover, will be of great benefit to Australian biodiversity and to the ecosystem processes and human values that depend on it.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC150100019
Funder
Australian Research Council
Funding Amount
$4,571,797.00
Summary
ARC Training Centre for Liquefied Natural Gas Futures. ARC Training Centre for Liquefied Natural Gas Futures. This training centre aims to deliver projects and training to enable future Australian Liquefied Natural Gas (LNG) production from reserves in deep water, at small or remote on-shore locations, with greater efficiency, less environmental impact, and at lower cost than currently possible. This should be accomplished via research projects undertaken by the PhD students and research fellows ....ARC Training Centre for Liquefied Natural Gas Futures. ARC Training Centre for Liquefied Natural Gas Futures. This training centre aims to deliver projects and training to enable future Australian Liquefied Natural Gas (LNG) production from reserves in deep water, at small or remote on-shore locations, with greater efficiency, less environmental impact, and at lower cost than currently possible. This should be accomplished via research projects undertaken by the PhD students and research fellows with guidance from the centre’s industrial partners. The centre’s expected legacy is a unique research and training facility, designed for future integration into a microscale LNG plant. The anticipated research and training outcomes will help to ensure Australia plays a leading role in future global LNG developments.Read moreRead less
Movement ecology of granivores: informing fire management of savannas. This project aims to examine the decline in granivorous finches across north Australia and test the hypothesis that an increasingly nomadic lifestyle, associated with tracking grass seed availability over larger spatial scales, is the cause. The project also aims to evaluate how fire affects rangeland functioning, particularly grass diversity, to improve fire management of tropical savannas in northern Australia. This project ....Movement ecology of granivores: informing fire management of savannas. This project aims to examine the decline in granivorous finches across north Australia and test the hypothesis that an increasingly nomadic lifestyle, associated with tracking grass seed availability over larger spatial scales, is the cause. The project also aims to evaluate how fire affects rangeland functioning, particularly grass diversity, to improve fire management of tropical savannas in northern Australia. This project will provide new tools and technologies that will monitor mobile small vertebrates. Expected outcomes will improve the understanding of tropical savanna functioning and fire management. The research aligns with ‘savanna burning’ methodologies and carbon sequestration goals in north Australia.
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