Analysis Of CD95L And TRAIL Apoptotic Pathways In Glioma.
Funder
National Health and Medical Research Council
Funding Amount
$423,055.00
Summary
Most patients with the brain cancer malignant glioma die within two years of diagnosis, thus innovative approaches to treatment are desperately needed. Mutations which prevent the precancerous cells from responding to suicide (apoptotic) signals can contribute to tumourigenesis. As standard treatment regimes act by inducing this cellular suicide machinery, tumour cells with apoptotic pathway alterations can be resistant to conventional therapies. Malignant gliomas are typically resistant to chem ....Most patients with the brain cancer malignant glioma die within two years of diagnosis, thus innovative approaches to treatment are desperately needed. Mutations which prevent the precancerous cells from responding to suicide (apoptotic) signals can contribute to tumourigenesis. As standard treatment regimes act by inducing this cellular suicide machinery, tumour cells with apoptotic pathway alterations can be resistant to conventional therapies. Malignant gliomas are typically resistant to chemo- and radiotherapy, and therefore may have altered apoptotic pathways. By identifying the components of apoptotic pathways in glioma cells, rational design of either novel drugs, or treatments which will restore-enable susceptibility of the tumour cells to currently available therapies will be feasible. Here we will focus on the suicide pathways triggered by the molecules CD95L and TRAIL. We will characterise the sensitivity of glioma cells to CD95L and TRAIL, chemotherapeutic drugs and irradiation. We will then systematically survey the molecules implicated in CD95L and TRAIL-mediated cell death, based on studies in other cell types, to determine the relevant components of the molecular pathways which lead to apoptosis following CD95L-TRAIL exposure. We will also assess the roles played by known inhibitors, in determining resistance to CD95L and-or TRAIL, and will perform screens for novel inhibitors of these pathways. This study will elucidate the molecules responsible for the CD95L-TRAIL-mediated apoptosis seen in some glioma cells, and the molecules which confer resistance to these treatments in others. We will also learn whether the typical resistance to chemo- and radiotherapy observed in gliomas is mechanistically linked to resistance to CD95 and-or TRAIL resistance. This knowledge will be valuable for the rational design of diagnostic and therapeutic agents for glioma, and potentially for other diseases.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100184
Funder
Australian Research Council
Funding Amount
$1,034,832.00
Summary
A new catchment gully erosion model for a healthier Great Barrier Reef . Sediment impacts Great Barrier Reef water quality and coral health. Erosion of gullies within a river catchment are the dominant source of sediment. This project aims to develop a novel catchment level modelling tool, allowing land managers to compare rehabilitation options and identify optimal actions. The project will generate new knowledge in applied mathematics, using innovative model emulation techniques to bring proce ....A new catchment gully erosion model for a healthier Great Barrier Reef . Sediment impacts Great Barrier Reef water quality and coral health. Erosion of gullies within a river catchment are the dominant source of sediment. This project aims to develop a novel catchment level modelling tool, allowing land managers to compare rehabilitation options and identify optimal actions. The project will generate new knowledge in applied mathematics, using innovative model emulation techniques to bring process insights to the catchment scale. Expected outcomes include a validated land rehabilitation decision making tool, benefiting both natural resource managers by increasing ability to meet Reef 2050 policy targets and landowners though development of Natural Capital Markets.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100008
Funder
Australian Research Council
Funding Amount
$889,419.00
Summary
Reinventing compostable packaging. This project aims to develop a new generation of authentically home-compostable packaging materials, focused around meeting immediate and future needs for food packaging. The materials used will be of sustainable origin, helping to decarbonise our packaging industry, and presenting a new paradigm in protecting consumer goods in a more responsible way. In doing so, it is anticipated that Australia will be able to reduce and eventually avoid reliance on single-us ....Reinventing compostable packaging. This project aims to develop a new generation of authentically home-compostable packaging materials, focused around meeting immediate and future needs for food packaging. The materials used will be of sustainable origin, helping to decarbonise our packaging industry, and presenting a new paradigm in protecting consumer goods in a more responsible way. In doing so, it is anticipated that Australia will be able to reduce and eventually avoid reliance on single-use plastic packaging in foods and the environmental problems it causes, without compromising on food safety or freshness.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100992
Funder
Australian Research Council
Funding Amount
$426,216.00
Summary
A novel epigenetic clock tool to conserve Australia’s threatened seabirds. The aim is to develop a novel epigenetic technique for the demographic assessment of long-lived seabirds, including albatrosses and petrels, for application to the conservation of 11 threatened species breeding across Australia. A major innovation will be an affordable and fieldwork-friendly technique to demographically fingerprint any population, ending the large amount of guesswork currently necessary in management. The ....A novel epigenetic clock tool to conserve Australia’s threatened seabirds. The aim is to develop a novel epigenetic technique for the demographic assessment of long-lived seabirds, including albatrosses and petrels, for application to the conservation of 11 threatened species breeding across Australia. A major innovation will be an affordable and fieldwork-friendly technique to demographically fingerprint any population, ending the large amount of guesswork currently necessary in management. The outcome is expected to enable (i) scientists and wildlife managers to impute the impact of threats and management activities on seabird populations, allowing quantitative scenario modelling, and (ii) stakeholders to analyse numerous threats and optimise management responses to these through research-based decision-making.Read moreRead less
Restoring & future-proofing the biocultural values of endangered seagrasses. This project aims to develop best-practice methods for the biocultural restoration of the endangered seagrass Posidonia australis. This species is highly productive, supports fisheries and biodiversity, and plays a key role in mitigating climate change. This project will generate valuable new genetic information to guide restoration strategies including climate-adjusted genotypes. Working with Indigenous groups, we aim ....Restoring & future-proofing the biocultural values of endangered seagrasses. This project aims to develop best-practice methods for the biocultural restoration of the endangered seagrass Posidonia australis. This species is highly productive, supports fisheries and biodiversity, and plays a key role in mitigating climate change. This project will generate valuable new genetic information to guide restoration strategies including climate-adjusted genotypes. Working with Indigenous groups, we aim to document and restore cultural values associated with Posidonia. Working with industrial designers, we seek to develop cost-effective techniques to scale-up seagrass restoration. This research should provide significant environmental, economic, social and cultural benefits by improving seagrass restoration.Read moreRead less
Creating coolspots: eco-engineering heat-resistant intertidal communities. This project aims to identify structural characteristics of marine intertidal habitat patches, formed by seaweeds and shellfish, that protect associated species from thermal extremes. This project will generate new knowledge about how thermally sensitive intertidal species can persist in stressful environments. Expected outcomes of this project
include new approaches for building heat-tolerant ecological communities on co ....Creating coolspots: eco-engineering heat-resistant intertidal communities. This project aims to identify structural characteristics of marine intertidal habitat patches, formed by seaweeds and shellfish, that protect associated species from thermal extremes. This project will generate new knowledge about how thermally sensitive intertidal species can persist in stressful environments. Expected outcomes of this project
include new approaches for building heat-tolerant ecological communities on coastal infrastructure, and improved tools for predicting the response of intertidal seaweeds and animals to environmental change. The results of this project will benefit coastal management by identifying conservation and rehabilitation strategies that maximise the
resilience of coastal ecosystems to environmental change.Read moreRead less
Do root microbiomes control seagrass response to environmental stress? The project aims to determine the role root microbes play in controlling seagrass responses to environmental stress. By integrating marine and microbial ecology, environmental genomics and ecosystem function (e.g., biogeochemical cycling), this project is significant as it will create new knowledge of the processes that confer seagrass resilience to global environmental issues. An expected outcome is an increased understandin ....Do root microbiomes control seagrass response to environmental stress? The project aims to determine the role root microbes play in controlling seagrass responses to environmental stress. By integrating marine and microbial ecology, environmental genomics and ecosystem function (e.g., biogeochemical cycling), this project is significant as it will create new knowledge of the processes that confer seagrass resilience to global environmental issues. An expected outcome is an increased understanding of how microbes control seagrass health and an enhanced capacity to develop effective restoration strategies for Australia's valuable seagrass ecosystems. Benefits include improving the extensive environmental, economic, social/cultural services Australian communities derive from seagrass ecosystems.Read moreRead less
Unusual trisulfide chemistry. This project aims to investigate the mechanism of an unexpected reaction of trisulfides with common amide-containing solvents. Specifically, these solvents (such as dimethylformamide) were discovered to cleave S-S bonds in trisulfides and related polysulfides. This project expects to generate new knowledge in the understanding of the reaction mechanism and then use that understanding for useful chemistry. Expected outcomes of this project include a mechanistic under ....Unusual trisulfide chemistry. This project aims to investigate the mechanism of an unexpected reaction of trisulfides with common amide-containing solvents. Specifically, these solvents (such as dimethylformamide) were discovered to cleave S-S bonds in trisulfides and related polysulfides. This project expects to generate new knowledge in the understanding of the reaction mechanism and then use that understanding for useful chemistry. Expected outcomes of this project include a mechanistic understanding of a new reaction, and the use of this chemistry in polymer synthesis and polymer recycling. This project should provide significant benefits in new knowledge, as well as support new strategies in polymer synthesis and recycling to benefit the environment.Read moreRead less
Carbon fibre thermoplastics as next-generation carbon fibre composites. By combining sizing, chemical grafting, and nano-reinforcement strategies, this project develops chemically and thermally robust thermoplastic interfacial sizing for carbon fiber/thermoplastic composites for rapid manufacturing. Thermostamped carbon fiber/thermoplastic composite prototypes will be used to verify the sizing. In order to demonstrate industrial viability, recyclability and reprocessability analyses will be cond ....Carbon fibre thermoplastics as next-generation carbon fibre composites. By combining sizing, chemical grafting, and nano-reinforcement strategies, this project develops chemically and thermally robust thermoplastic interfacial sizing for carbon fiber/thermoplastic composites for rapid manufacturing. Thermostamped carbon fiber/thermoplastic composite prototypes will be used to verify the sizing. In order to demonstrate industrial viability, recyclability and reprocessability analyses will be conducted. This sizing method can enable high-performance thermoplastic composites in nonaerospace applications with its atomistic level modelling and comprehensive characterisation routine. A key objective of this study is to produce sustainably manufactured composite materials that are also commercially relevant.Read moreRead less