Identifying Resistance Mechanisms Of Targeted BRAF Inhibitors In Metastatic Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$379,015.00
Summary
Late-stage melanoma is an aggressive skin cancer for which traditional treatment strategies such as chemotherapy are ineffective. Recently, a new class of targeted drugs (BRAF inhibitors) has become the standard of care for a subset of melanoma patients; however, long term treatment success is complicated by drug resistance. This study will identify the causes of resistance with the purpose to improve targeted drug strategies and increase survival rates for late-stage melanoma patients.
Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population a ....Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population and people with bone abnormalities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101854
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Exploring A New Family of 2D Heterogeneous Topological Insulator. The project aims to reveal a new family of two-dimensional heterostructure topological insulators by extensive theoretical simulations, and develop feasible approaches to control the topological phase, thus enabling their use in practical nanodevice applications. The project aims not only to advance knowledge in material chemistry and condensed matter physics, but also to lead to technology revolutions in information technology, c ....Exploring A New Family of 2D Heterogeneous Topological Insulator. The project aims to reveal a new family of two-dimensional heterostructure topological insulators by extensive theoretical simulations, and develop feasible approaches to control the topological phase, thus enabling their use in practical nanodevice applications. The project aims not only to advance knowledge in material chemistry and condensed matter physics, but also to lead to technology revolutions in information technology, clean energy generation and cooling devices based on topological insulators. The outcomes are expected to produce new technology applications in electronics, communications, information technology, data storage and transportation.Read moreRead less
New high energy density cathode materials for lithium ion batteries. This project aims to develop new high-energy-density and low-cost lithium-rich cathode materials for advanced lithium-ion batteries that can store solar energy for Australian households and power the next generation electric vehicles. The project will design innovative strategies to suppress the voltage decay and capacity decline of the lithium rich materials over long-term cycling. The project expects to significantly improve ....New high energy density cathode materials for lithium ion batteries. This project aims to develop new high-energy-density and low-cost lithium-rich cathode materials for advanced lithium-ion batteries that can store solar energy for Australian households and power the next generation electric vehicles. The project will design innovative strategies to suppress the voltage decay and capacity decline of the lithium rich materials over long-term cycling. The project expects to significantly improve battery performance at a lower price and make a substantial impact to the energy supply technologies and industries in Australia and benefit the environment in the long run.Read moreRead less
Consumer value and disability services: The impact of increased autonomy. This project seeks to explore a key question of the National Disability Insurance Scheme (NDIS): will service provision improve when service users have the ability to choose? In 2016, the NDIS will start rolling out and nearly half a million people with a disability will be able to choose disability services. The project aims to identify changes in objective and perceived consumer value pre-NDIS and post-NDIS, and differen ....Consumer value and disability services: The impact of increased autonomy. This project seeks to explore a key question of the National Disability Insurance Scheme (NDIS): will service provision improve when service users have the ability to choose? In 2016, the NDIS will start rolling out and nearly half a million people with a disability will be able to choose disability services. The project aims to identify changes in objective and perceived consumer value pre-NDIS and post-NDIS, and differences in how market segments use their autonomy and whether this leads to differences in benefits gained from the NDIS. Findings are intended to contribute to a better understanding of when free market mechanisms serve the needs of their citizens better than traditional means of government support.Read moreRead less
A defect mechanism for oxygen reduction reaction. This project aims to use defective carbon to replace expensive platinum as a catalyst for oxygen reduction reaction (ORR) in fuel cells. Defective carbons incorporating non-precious metals are better than platinum in terms of over-potential, current density and number of electron transfer. They reduce the overall fuel cell cost but their better stability and higher open voltage and power density promise huge commercial benefit. This project is ex ....A defect mechanism for oxygen reduction reaction. This project aims to use defective carbon to replace expensive platinum as a catalyst for oxygen reduction reaction (ORR) in fuel cells. Defective carbons incorporating non-precious metals are better than platinum in terms of over-potential, current density and number of electron transfer. They reduce the overall fuel cell cost but their better stability and higher open voltage and power density promise huge commercial benefit. This project is expected to be important for large-scale implementation of fuel cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101056
Funder
Australian Research Council
Funding Amount
$380,156.00
Summary
Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-partic ....Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-particle level and the choice of optimal SERS-active three-dimensional superstructures for use will be guided by empirical structure-activity correlations in combination with computer simulations. Tumour biomarkers for breast cancer will be employed as the model target for establishing the detection platform in a portable configuration for point-of-care diagnostics.Read moreRead less
Poly(dendrimer) organic light-emitting diodes. This project aims to develop ultrathin efficient emissive technologies based on low embedded energy organic light-emitting diodes (OLEDs). It will develop transformative OLEDs that can be used in displays and lighting, by creating semiconductor materials and diode architectures that optimise each step in light generation, from charge injection, transport and capture to light emission. The efficiency improvements made possible by OLED technology can ....Poly(dendrimer) organic light-emitting diodes. This project aims to develop ultrathin efficient emissive technologies based on low embedded energy organic light-emitting diodes (OLEDs). It will develop transformative OLEDs that can be used in displays and lighting, by creating semiconductor materials and diode architectures that optimise each step in light generation, from charge injection, transport and capture to light emission. The efficiency improvements made possible by OLED technology can reduce electricity consumption, carbon dioxide emissions, and the cost of living.Read moreRead less