Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Advanced adsorbents for gas separations. Efficient purification of natural gas and separation of similarly-sized molecules in gas mixtures is increasingly important in our drive to develop a more sustainable way of living in an energy-constrained world. This project will develop a new class of adsorbents to deliver a level of separation efficiency much higher than that currently in use.
Smart materials from semi-soft particles. This project will combine precision polymer chemistry to material science to develop structured nanoparticles for applications in photonics and shape memory materials.
Maximising value in underground mine planning. Mining is crucial to Australia’s economy, contributing 8 per cent of GDP and 55 per cent of the value of goods exported. Working with mining companies Rand and Tribune, this project tackles issues faced in underground mine planning. While integrated optimisation of design and production in open cut mining is well established, no equivalent capability is available for underground mines. This project aims to develop innovative techniques to optimise t ....Maximising value in underground mine planning. Mining is crucial to Australia’s economy, contributing 8 per cent of GDP and 55 per cent of the value of goods exported. Working with mining companies Rand and Tribune, this project tackles issues faced in underground mine planning. While integrated optimisation of design and production in open cut mining is well established, no equivalent capability is available for underground mines. This project aims to develop innovative techniques to optimise the design of the access network and the production scheduling in an underground mine in order to maximise value over the life of the operation. The outcome intends to be a new strategic software tools for the sector, underpinning increased efficiency and sustainability of Australian mines as well as international competitiveness.Read moreRead less
Certified evaluation of uncertainty in models of dynamical systems. The purpose of this project is to develop methods which will aid engineers to better analyse the accuracy of models created using experimental data. To support the use of the methods, a toolbox with software implementations will also be developed.
Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisat ....Soft materials containing hierarchy via 3D sacrificial micro-moulding. The project seeks to develop sophisticated new polymeric materials and devices not possible using current manufacturing techniques. Biomaterials based on hydrogels are ideal substrates for synthetic extra-cellular matrices due to their high water content. However, one of the challenges hindering the use of hydrogels is reproducing the transport properties found in natural tissue with hierarchical features such as vascularisation. To address this, the project plans to develop a 3D moulding process for generating soft materials containing precise channels decorated with defined molecules. Intended outcomes include a fundamental understanding of the 3D moulding process, and new polymers and advanced tools for bioengineers for future applications such as tissue transplants, cell guides for treating spinal cord injuries, soft robotics and microfluidic devices to study cancer metastasis. Read moreRead less
Maximisation of value in underground mine access design. This project represents a major advance in the problem of optimising the mine value associated with the access infrastructure of underground mines and providing powerful planning tools for management. The usefulness to the mining industry of the methods and algorithms the project is pioneering lies in their accuracy, flexibility and generality. Not only can they be used for benchmarking value in the design of specific mines, but they can ....Maximisation of value in underground mine access design. This project represents a major advance in the problem of optimising the mine value associated with the access infrastructure of underground mines and providing powerful planning tools for management. The usefulness to the mining industry of the methods and algorithms the project is pioneering lies in their accuracy, flexibility and generality. Not only can they be used for benchmarking value in the design of specific mines, but they can also determine the profitability or viability of mines under the use of new technologies. This is an important project for ensuring that Australia's mining industry remains efficient and internationally competitive. Given Australia’s economic dependence on mineral resources, it will also benefit the country as a whole.Read moreRead less
Rechargeable lithium carbon dioxide battery - catalyst design to prototype . This project aims to develop a new concept of rechargeable lithium carbon dioxide batteries and scaled-up prototypes. Such a battery will be first of its kind to show high power comparable to gasoline and superior rechargeability over existing gas-involved batteries, ensuring realistic use for industrial purposes. Expected outcomes include 2-dimensional catalysts made from earth-abundant elements lowering large-scale pr ....Rechargeable lithium carbon dioxide battery - catalyst design to prototype . This project aims to develop a new concept of rechargeable lithium carbon dioxide batteries and scaled-up prototypes. Such a battery will be first of its kind to show high power comparable to gasoline and superior rechargeability over existing gas-involved batteries, ensuring realistic use for industrial purposes. Expected outcomes include 2-dimensional catalysts made from earth-abundant elements lowering large-scale production cost, a novel but reliable working principle based on reversible carbon dioxide/oxalate conversion, and prototypes featuring high specific capacity, large energy density and excellent durability. Via industrial pilot trials, commercial benefits will be fast tracked for energy security and carbon dioxide utilisation.Read moreRead less