Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100042
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Next generation facility to measure microfluidic flows. Microfluidics is ubiquitous in society - for example, biofluids and engineered lab-on-a-chip platforms. This project aims to establish a novel flow measurement facility tailored for microfluidic flows with capabilities beyond current commercial flow diagnostic systems. This will enable engineers and scientists to probe the fluid dynamics of these flows with unprecedented detail to explain their underlying physical mechanisms. Beyond fluidic ....Next generation facility to measure microfluidic flows. Microfluidics is ubiquitous in society - for example, biofluids and engineered lab-on-a-chip platforms. This project aims to establish a novel flow measurement facility tailored for microfluidic flows with capabilities beyond current commercial flow diagnostic systems. This will enable engineers and scientists to probe the fluid dynamics of these flows with unprecedented detail to explain their underlying physical mechanisms. Beyond fluidic measurement, the facility provides the capacity to accurately observe micro-organisms, biological activity (cell adhesion, thrombus stability, fluorescent receptor markers), thermal collector systems (high flux, microchannel-based solar receivers), and many more mechanical phenomena at the micro-scale.
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Particle scale modelling and analysis of the multiphase flows in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, with an annual value >$20 billion. Optimum design and control of the processes in coal preparation play a critical economic role in coal production. This project aims at providing substantial improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements ta ....Particle scale modelling and analysis of the multiphase flows in coal preparation. Australia is the world's biggest coal exporter, and black coal is Australia's largest export, with an annual value >$20 billion. Optimum design and control of the processes in coal preparation play a critical economic role in coal production. This project aims at providing substantial improvements through the application of a novel combined continuum and discrete modelling method. Specifically, the improvements targeted relate to better process and product control, a decrease in unit energy consumption and improvements in productivity, which, together with the research training offered, will further enhance Australia's leading position in global coal industry.Read moreRead less
Fundamental studies of multiphase flow and separation performance of natural medium cyclones for recovering waste coal. This project aims to develop an effective method to design, control and optimise natural medium cyclones for recovering waste coal, important for environmental protection and for energy efficiency. Its conduct will enhance Australia's leading position in the coal industry.
THE DEVELOPMENT OF MECHANISTIC MODELS FOR BUBBLY FLOWS WITH HEAT AND MASS TRANSFER. Commercially available CFD computer codes are currently widely used in many Australian industrial sectors. It is clearly recognised that the state-of-the-art models for dealing with complex bubbly flows with/without heat and mass transfer in these computer codes require further developments and improvements. This research project will address the prevalent deficiency in many of these computer codes. It is antici ....THE DEVELOPMENT OF MECHANISTIC MODELS FOR BUBBLY FLOWS WITH HEAT AND MASS TRANSFER. Commercially available CFD computer codes are currently widely used in many Australian industrial sectors. It is clearly recognised that the state-of-the-art models for dealing with complex bubbly flows with/without heat and mass transfer in these computer codes require further developments and improvements. This research project will address the prevalent deficiency in many of these computer codes. It is anticipated that through this major development of new models capable of predicting a wide range of industrial bubbly flow problems and implementation thereafter in these computer codes, industries will experience significant benefits especially reduce time and costs in their design and production.Read moreRead less
Experimental and Numerical Modelling of Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of ....Experimental and Numerical Modelling of Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of predicting a wide range of industrial bubbly flow problems. The resultant improved computer codes will provide industries with significant benefits - especially reduced times and costs in their design and production.Read moreRead less
Improving respiratory drug delivery through targeted nozzle design. The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between t ....Improving respiratory drug delivery through targeted nozzle design. The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between the geometry of pressurised, metered-dose inhaler components and the drug particles these devices produce. The long term benefit from this research will be improved delivery efficiency and shorter product development times, leading to reduced dose-rate costs. This understanding will enable the development of the next generation of treatment devices with enhanced efficiency in delivery of the drugs used to treat these diseases and reduced costs per dose.Read moreRead less
Particle-scale modelling of particle-fluid flows in gas and oil extraction. Particle-scale modelling of particle-fluid flows in gas and oil extraction. This project aims to develop a particle scale model to study the pipeline transport of petroleum fluids. It will use a combined theoretical and experimental program, involving state-of-the-art discrete element modelling and simulation techniques, to describe the complex particle-fluid flow and erosion of pipeline transport in gas and oil extracti ....Particle-scale modelling of particle-fluid flows in gas and oil extraction. Particle-scale modelling of particle-fluid flows in gas and oil extraction. This project aims to develop a particle scale model to study the pipeline transport of petroleum fluids. It will use a combined theoretical and experimental program, involving state-of-the-art discrete element modelling and simulation techniques, to describe the complex particle-fluid flow and erosion of pipeline transport in gas and oil extraction, quantify the effects of key variables, and formulate strategies for optimum process control under different conditions. The research outcomes are expected to be useful for the process control of pipeline transport in Australia’s important petroleum and energy-related industries.Read moreRead less
Smart hybrid system for the formulation and design of dry powder inhalers. This project aims to develop a greater understanding of the link between inhaler device components and the dry powder formulation within. From this understanding, the project aims to develop a hybrid model for the design and manufacture of dry powder inhalers with improved aerosol deposition performances as well as an enhanced capacity to predict formulation performance. The long term benefits will be improved delivery ef ....Smart hybrid system for the formulation and design of dry powder inhalers. This project aims to develop a greater understanding of the link between inhaler device components and the dry powder formulation within. From this understanding, the project aims to develop a hybrid model for the design and manufacture of dry powder inhalers with improved aerosol deposition performances as well as an enhanced capacity to predict formulation performance. The long term benefits will be improved delivery efficiency and shorter development times, leading to reduced manufacturing costs.Read moreRead less
A fundamental study of milk ultrafiltration. The Dairy Industry is one of Australia's largest domestic and export industries. The fundamental knowledge and models developed in this project will be used to optimise dairy membrane processing. This will reduce water and energy use to improve the global competitiveness and reduce the environmental impact of the Australian Dairy Industry.