Role Of AMPK Signaling In Metabolic Control During Exercise
Funder
National Health and Medical Research Council
Funding Amount
$566,288.00
Summary
It is well recognized that sedentary life styles are associated with increased incidence of obesity, Type 2 diabetes and atherosclerotic cardiovascular disease. The medical, social and financial costs of these diseases are growing rapidly and represent a major health care challenge. Exercise is beneficial for maintaining health in patients at risk of developing these diseases and for this reason we are interested in understanding how exercise capacity is regulated.
NAFLD, NASH And Hepatocellular Carcinoma: Mechanisms & Potential Treatments
Funder
National Health and Medical Research Council
Funding Amount
$692,992.00
Summary
Liver cancer is one of the most common and fatal cancers world-wide. In developed countries, the past three decades has seen its incidence treble becoming the fastest rising cause of cancer deaths. In some patients liver cancer seems to be caused by obesity. The reason why some obese patients get liver cancer and others do not is unknown. In addition, there are few treatment options. In these studies we will research what causes liver cancer in obesity and test two new potential therapies.