Peroxisome Proliferator-activated Receptors: A Role In The Promotion Of Mammary Gland Carcinogenesis By Dietary Fat.
Funder
National Health and Medical Research Council
Funding Amount
$188,702.00
Summary
Breast cancer is a leading cause of death in Australian women. While some women have a hereditary predisposition to breast cancer, for most women a variety of factors are responsible for their disease. One thing that appears to be important as a cause of breast cancer is our diet. There are many components of the diet that may play a role. One important factor is the amount and type of fat that we consume. Just how dietary fat causes an increase in breast cancer is not known. What this project a ....Breast cancer is a leading cause of death in Australian women. While some women have a hereditary predisposition to breast cancer, for most women a variety of factors are responsible for their disease. One thing that appears to be important as a cause of breast cancer is our diet. There are many components of the diet that may play a role. One important factor is the amount and type of fat that we consume. Just how dietary fat causes an increase in breast cancer is not known. What this project aims to achieve is an understanding of how dietary fat and breast cancer are related. If we can understand this then we can rationally design treatments or a preventative strategy.Read moreRead less
The Differential Innervation Of Fat - Potential To Target Visceral Adiposity
Funder
National Health and Medical Research Council
Funding Amount
$486,818.00
Summary
Levels of abdominal fat are closely correlated with metabolic syndrome. We propose experiments to identify unique characteristics (neurotransmitters or receptors) of neurons deep in the brain that project specifically to this type of fat or other less harmful subcutaneous fat. We can then test the functional significance of these unique elements in animal experimets involving gene knockdown or pharmacological approaches to modify their function and test the effect on fat distribution
Dietary Therapies For The Treatment Of Drug-resistant Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$69,757.00
Summary
Epilepsy affects about 225,000 Australians, with 30% of suffers still experiencing seizures despite being on medications. A reduction in seizures can significantly improve the health of people with epilepsy who do not respond to medications. Low carbohydrate, high fat diets are a well-established treatment option in children, but this has not previously been studied in Australian adults. The aim of this research is to evaluate if dietary therapies are an effective treatment in adult epilepsy.
Determinants Of Brown Adipose Tissue Activation - Implication For The Regulation Of Energy Balance And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$617,192.00
Summary
One of the most important recent findings in the biology of obesity has been the revelation that brown adipose tissue (BAT) is present and functional in adult humans. Even more important, the amount of BAT seems to be related to the extent of obesity. The challenge now is to harness the means by which BAT is activated. Understanding the central neural control pathways and the rate limiting steps in the BAT itself will pave the way for new anti-obesity strategies.