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Genetic Variants, Phenotypic Spectrum And Breast Cancer Risk Associated With Germline Mutations In PALB2: Identifying Female PALB2 Mutation Carriers At The Time Of Diagnosis
Funder
National Health and Medical Research Council
Funding Amount
$45,093.00
Summary
Population studies of female breast cancer (BC) show only a small proportion of familial aspects of BC can be explained by current knowledge of its causes. Women carrying PALB2 mutations who also have a strong family history of BC are of increased risk of BC. Our work will further define the risks and devise criteria to identify women most likely to carry PALB2 mutations. This will help prioritize testing, classify PALB2 variants and provide appropriate clinical management to carriers.
Determining Patients And Doctors Preferences For Chemotherapy And Incorporating Them Into Clinical Decision-making
Funder
National Health and Medical Research Council
Funding Amount
$87,234.00
Summary
Chemotherapy improves survival in early lung cancer and advanced ovarian cancer but has significant side effects. Recent advances in chemotherapy have not been widely adopted because of differing opinions about whether the benefits of these treatments outweigh their harms. This research program will determine the benefits that patients and their doctors judge necessary to make these treatments worthwhile, and how best to incorporate this information into clinical discussions and decision-making.
Clinicopathological Characterisation Of Male Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Male Breast Cancer is an uncommon and poorly understood disease. Due to its low frequency, there is a paucity of studies with large numbers of patients. Our aim will be to establish one of the largest worldwide databases of Male Breast Cancer. This will allow us to more thoroughly investigate clinical, pathological and molecular characteristics of male breast cancer, improve treatment of these patients and potentially develop novel and innovative strategies for treatment of female breast cancer.
The Effectiveness Of Mindfulness Practices In Reducing Distress In Children Diagnosed With Cancer And Their Parents.
Funder
National Health and Medical Research Council
Funding Amount
$22,019.00
Summary
This research project aims to investigate the effectiveness of mindfulness based cognitive therapy, an intervention using specific meditation and thought techniques, to reduce psychological distress in children who have been diagnosed with cancer and their parents. Specifically, symptoms of depression, anxiety and stress related to the experience of the illness will be targeted.
Advanced Anti-cancer Activities With Therapeutic Agents That Induce Tumor Cell Apoptosis And Antitumor Immune Responses.
Funder
National Health and Medical Research Council
Funding Amount
$85,701.00
Summary
The aim is to perform pre-clinical studies to identify new therapies for blood cancers. We will utilise three new anti-cancer agents that kill tumor cells and genetically engineered mice that develop cancer. We will determine if these three new agents kill the mouse tumor cells and activate anti-tumor immunity. The combined effect of killing blood cancer cells using new therapeutics, coupled with enhancing the anti-cancer immune response may hold the key to developing new treatments.
Clinical And Molecular Analyses Of Nodular Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$130,904.00
Summary
There have been very recent advances in our understanding of the biology of melanoma that are now poised to have major impacts in the outcome of patients with this disease. The nodular subtype of melanoma contributes disproportionately to mortality from melanoma. By using the latest molecular techniques to study these melanomas I will identify causative factors, diagnostic features and molecular profiles associated with these poor-prognosis melanomas leading to new approaches in the prevention, ....There have been very recent advances in our understanding of the biology of melanoma that are now poised to have major impacts in the outcome of patients with this disease. The nodular subtype of melanoma contributes disproportionately to mortality from melanoma. By using the latest molecular techniques to study these melanomas I will identify causative factors, diagnostic features and molecular profiles associated with these poor-prognosis melanomas leading to new approaches in the prevention, early detection and treatment of these melanomas.Read moreRead less
The Relationship Between Environmental Exposures And The Development Of Acute Lymphoblastic Leukaemia In Children
Funder
National Health and Medical Research Council
Funding Amount
$88,141.00
Summary
Leukaemia is the most common childhood cancer and is potentially preventable. Little is known about the causes, although it is likely that both genetic and environmental factors play a role. The early age at diagnosis suggests that exposures before birth or in early childhood, may be involved in its development. This study will investigate whether non-occupational environmental exposures in these key time periods increase the risk of disease and thus may help to prevent the disease.