Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$583,477.00
Summary
Ross River virus and chikungunya virus cause muscle and joint pain that can persist for a long time. This project looks at factors in the human host that affect the disease severity, with the aim of finding new treatments.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100123
Funder
Australian Research Council
Funding Amount
$1,100,000.00
Summary
The Digitisation Centre of Western Australia (Phase 1). All five Western Australian Universities, the WA State Library and the WA Museum will collaborate to establish a world-class archival quality Digitisation Centre. There is no existing facility of this kind in WA. During this 12 month project all digitisation equipment will be acquired, installed and used to digitise a diverse range of cultural objects so as to ensure its ability to address the full spectrum of research needs. The Digitisati ....The Digitisation Centre of Western Australia (Phase 1). All five Western Australian Universities, the WA State Library and the WA Museum will collaborate to establish a world-class archival quality Digitisation Centre. There is no existing facility of this kind in WA. During this 12 month project all digitisation equipment will be acquired, installed and used to digitise a diverse range of cultural objects so as to ensure its ability to address the full spectrum of research needs. The Digitisation Centre will form a major piece of national research infrastructure with a prominent international profile and significance. The Centre will have the capacity to digitise all significant Humanities, Arts and Social Sciences (HASS) research collections held by participating institutions within a decade.Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Quit In General Practice: A Cluster Randomised Trial Of Enhanced In-practice Support For Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$1,117,241.00
Summary
Tobacco smoking remains the most common preventable cause of death and illness in Australia today. Smoking cessation programs are some of the most effective and cost effective strategies that can be undertaken in health care settings, including general practice. This project will test a new approach to supporting smoking cessation in general practice. This involves the practice nurse, GP and Quitline working in partnership to provide a flexible program of suport to meet the needs of smokers.
Sino-Australian neurogenetics initiative. This project will undertake large population studies to identify genes that are associated with motor neuron disease, schizophrenia and intracranial haemorrhage. The project will determine genetic markers, aid development of diagnostic tools and identify new therapeutic targets for these common heritable neurological diseases.
Australian art exhibitions 1968-2009: a generation of cultural transformation. The years 1968 to 2009 witnessed a transformation in the way Australians saw the art of their country. This project investigates the impact of increased funding (government and private) and new scholarship on the curating of art exhibitions, and traces the reconfiguration of Australia’s art history that took place in exhibitions during this period.
Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' d ....Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' depends on an informed understanding of previous and current expectations about and attitudes to ageing in Australia. The history of old age is a complex rather than simple story, and successful policy development will require a solid historical foundation.Read moreRead less
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.