Anion Binding and Sensing With Self-Assembled Metallo-Supramolecular Assemblies. Anions are of particular significance in several areas relating to the day-to-day lives of Australians; for example as contaminants in waterways and nuclear waste streams, as indicators of chemical weapons, and as antagonists in biological systems. The proposed research programme will investigate a relatively unexplored approach to binding and sensing anions. This will further research in the area of supramolecular ....Anion Binding and Sensing With Self-Assembled Metallo-Supramolecular Assemblies. Anions are of particular significance in several areas relating to the day-to-day lives of Australians; for example as contaminants in waterways and nuclear waste streams, as indicators of chemical weapons, and as antagonists in biological systems. The proposed research programme will investigate a relatively unexplored approach to binding and sensing anions. This will further research in the area of supramolecular chemistry, providing additional research expertise in this rapidly progressing area of the chemical sciences. In terms of Breakthrough science the targeted assemblies will shed further light on self-assembly processes involving ligands with different domains, placing Australian research at the forefront of such investigations.Read moreRead less
Internally decorated discrete Metallo-supramolecular Assemblies and infinite Metal-Organic Frameworks as molecular containers. In the macroscopic world, containers are used to hold, provide physical protection, or create a modified environment for their contents. This project will result in the synthesis of novel molecular container materials that provide decorated internal surfaces capable of selectively binding chemical species. In addition to the breakthrough scientific benefits of establish ....Internally decorated discrete Metallo-supramolecular Assemblies and infinite Metal-Organic Frameworks as molecular containers. In the macroscopic world, containers are used to hold, provide physical protection, or create a modified environment for their contents. This project will result in the synthesis of novel molecular container materials that provide decorated internal surfaces capable of selectively binding chemical species. In addition to the breakthrough scientific benefits of establishing the fundamentals of these systems, the binding of chemicals, which are environmental contaminants, will provide the grounding for applications that will contribute to the national priority of 'Frontier technologies'. Furthermore, this research will lead to the training of the next generation of Australian scientists by quality international researchers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100462
Funder
Australian Research Council
Funding Amount
$364,975.00
Summary
Molecular complexity through multi-bond forming reactions. This project aims to develop techniques for the synthesis of many, highly valuable natural and designed molecules which are too complex to be synthesised on scale with current methodologies. The project aims to develop new strategies for the simultaneous construction of several chemical bonds, with a focus on molecular scaffolds that can be readily converted into pharmaceuticals, potential drug candidates, chiral ligands, and agrochemica ....Molecular complexity through multi-bond forming reactions. This project aims to develop techniques for the synthesis of many, highly valuable natural and designed molecules which are too complex to be synthesised on scale with current methodologies. The project aims to develop new strategies for the simultaneous construction of several chemical bonds, with a focus on molecular scaffolds that can be readily converted into pharmaceuticals, potential drug candidates, chiral ligands, and agrochemicals. This will ultimately lead to advancements in both the production and application of organic molecules in these fields.Read moreRead less
A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic ....A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic molecules of pharmaceutical importance and the training of highly skilled PhD students. This should provide significant benefits, such as increased capacity for the development of new pharmaceuticals and advanced materials.Read moreRead less
Development of Pyrrolopyrimidines as Inhibitors of ATP-Binding Proteins. This project seeks to generate analogues of natural products that have been found to be active against cancer cells and tropical parasites. The new materials produced by this project will aid in the study of biochemical processes involved in diseases such as cancer and lymphatic filariasis, thus leading the way to development of these compounds as potential treatments for such diseases.
New Discoveries in Organic Synthesis Inspired by the Efficiency of Nature. Nature can assemble complex organic molecules from simple starting materials with apparent ease, but the laboratory synthesis of these natural products is very difficult. This project aims to mimic the way in which Nature constructs organic compounds and thus develop more efficient, greener synthetic processes in which there is a rapid build up of molecular complexity via “biomimetic” reactions. We will integrate this app ....New Discoveries in Organic Synthesis Inspired by the Efficiency of Nature. Nature can assemble complex organic molecules from simple starting materials with apparent ease, but the laboratory synthesis of these natural products is very difficult. This project aims to mimic the way in which Nature constructs organic compounds and thus develop more efficient, greener synthetic processes in which there is a rapid build up of molecular complexity via “biomimetic” reactions. We will integrate this approach with modern methods of catalysis, including electrochemistry, photochemistry and biocatalysis. As a result, this work will expand the chemical space available to synthetic chemists working in the pharmaceutical industry. A further benefit is the training of the next generation of Australian synthetic chemists. Read moreRead less
Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic ....Using natural products to inspire discoveries in synthesis and biosynthesis. This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.Read moreRead less
New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is e ....New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is envisaged that these investigations will lead to the development of simple experimental protocols for the synthesis of new bioactive organics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100689
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Applying nature's chemistry to the synthesis of complex bioactive natural products. Organic molecules come in all shapes and sizes, and the synthesis of them is crucial to industries as diverse as pharmaceuticals, electronics, cosmetics and agrochemicals. This project aims to develop new ways of making unusual and potentially useful naturally occurring organic molecules using chemistry that mimics how they are formed in nature.
Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building bloc ....Predisposed organic synthesis inspired by the simplicty of nature. The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building blocks via predisposed, complexity generating cascade reactions. The project aims to generate new lead compounds for the advancement of next-generation antibiotics. The synthesis of proposed biosynthetic intermediates would also allow enzymatic studies to help confirm the novel biosynthetic proposals.Read moreRead less