More than half of the people living with Alzheimer’s disease experience visual impairments. These impairments may appear before memory problems begin to surface. This research investigates how those at risk of dementia explore the world visually, and how this changes over time. The findings will inform the design of dementia-friendly environments and answer the question whether the assessment of eye movement adds to the diagnosis and prognosis of cognitive impairments.
Using Health Outcome Data From Pooled Longitudinal Studies Of Ageing To Develop Statistical And Microsimulation Models T
Funder
National Health and Medical Research Council
Funding Amount
$2,162,630.00
Summary
This project draws together data from nine Australian Longitudinal Studies of Ageing (LSAs), including 53484 participants, that will be used to identify factors capable of preventing disease, reducing ill-health, and promoting engaged and successful ageing for Australians. The focus is upon conditions that significantly contribute to the burden of disease including cognitive decline and dementia, sensory impairment, impairment in mobility and common mental disorders such as depression. Although ....This project draws together data from nine Australian Longitudinal Studies of Ageing (LSAs), including 53484 participants, that will be used to identify factors capable of preventing disease, reducing ill-health, and promoting engaged and successful ageing for Australians. The focus is upon conditions that significantly contribute to the burden of disease including cognitive decline and dementia, sensory impairment, impairment in mobility and common mental disorders such as depression. Although individual studies contain rich data on particular topics, there is only a small number of individuals in each study with specific medical conditions, or combinations of different conditions, especially at the older ages. Pooling data from nine studies will overcome this problem. This innovative and interdisciplinary study also involves development of the first Australian dynamic micro-simulation model of the health and social outcomes of the baby boomer and older cohorts. The simulation will allow for evaluation of the impact of modifying risk factors, and costs associated with different trajectories of health and ageing. Our program takes an interdisciplinary life course approach, incorporating interdependencies among demographic, behavioural, social, economic and health factors. Our multidisciplinary team and collaborative pooling of existing studies adds value and builds upon experience, as recommended in the Prime Minister's Science, Engineering and Innovation Council 2003 report. The outcomes will direct health and social policy to promote health behaviour, and social and medical interventions to compress morbidity and optimize healthy ageing in Australian society over the next 40 years.Read moreRead less
Formulating New Goals For Global Health And Proposing New Governance For Global Health That Will Allow The Achievement Of These Goals
Funder
National Health and Medical Research Council
Funding Amount
$469,017.00
Summary
The Millennium Development Goals have guided global development since 2000, and are due for evaluation in 2015. Attention is now turning to New Health-Related Goals, with a governance structure to support their implementation. Australian researchers are joining a Go4Health consortium of 13 research institutions to research the development of these goals, examining the input of United Nations agencies and key donors into the process, together with communities, civil society and governments.
LIFEPATH: Life-course Biological Pathways Underlying Social Differences In Healthy Ageing
Funder
National Health and Medical Research Council
Funding Amount
$470,466.00
Summary
Healthy ageing varies across society due to environmental, behavioural and social circumstances that affect peoples’ lives. To improve our ability to change this we will investigate suspected biological mechanisms over the life course. Using repeated blood samples collected during a large prospective study, we will measure a very large number of biological markers and analyse these combined with lifestyle and behavioural information to identify the modifiable predictors of healthy ageing.
Hendra virus (HeV) cause a disease transmitted from bats to horses which in turn infect humans and other horses. There are no drugs or vaccines for HeV. Since humans are infected by inhalation, a vaccine that can generate antibody in the lung and protect from infection will be ideal. We have found that a natural sugar called mannan used with virus proteins and administered via the nostrils to generate such responses. In this project we will prepare this vaccine and use it in a mouse model of HeV ....Hendra virus (HeV) cause a disease transmitted from bats to horses which in turn infect humans and other horses. There are no drugs or vaccines for HeV. Since humans are infected by inhalation, a vaccine that can generate antibody in the lung and protect from infection will be ideal. We have found that a natural sugar called mannan used with virus proteins and administered via the nostrils to generate such responses. In this project we will prepare this vaccine and use it in a mouse model of HeV infection to see if it can protect the mice.Read moreRead less
Developing A National Salt Reduction Program For India
Funder
National Health and Medical Research Council
Funding Amount
$935,028.00
Summary
Excess dietary salt is a leading cause of premature strokes and heart attacks around the world. India, the world’s second most populous nation has no coordinated national salt reduction program and lacks key data upon which to formulate a strategy. This research will bring together Australian experts in the field with leading Indian researchers to make the baseline assessments required to formulate and commence population-wide salt reduction efforts in India.
This proposal uses the zebra fish system, which it is uniquely suited to investigate the regulation of disease genes. In all of these diseases preliminary work has already been performed and screening assays have been developed in a previous project (ZF-MODELS). In addition, the project will investigate genetic abnormalities of the eye and visual processing, genetic pathways underlying tissue regeneration and repair, and homologs of human genes related to diabetes and obesity, as well as infecti ....This proposal uses the zebra fish system, which it is uniquely suited to investigate the regulation of disease genes. In all of these diseases preliminary work has already been performed and screening assays have been developed in a previous project (ZF-MODELS). In addition, the project will investigate genetic abnormalities of the eye and visual processing, genetic pathways underlying tissue regeneration and repair, and homologs of human genes related to diabetes and obesity, as well as infectious disease and cancer. The Australian component will perform a systematic characterisation of enhancer elements of potential disease genes. This characterisation will build on the concept of genomic regulatory blocks (GRBs) which contain highly conserved non-coding elements (HCNEs) acting as long-range enhancers of developmental genes (recently discovered by T. Becker in the ZF-MODELS project).Read moreRead less
OptiMalVax: Optimizing A Deployable High Efficacy Malaria Vaccine
Funder
National Health and Medical Research Council
Funding Amount
$494,618.00
Summary
In this proposal, a consortium comprising many of the leading malariologists, vaccine researchers and product developers in Europe, USA, Australia and Africa will collaborate in an exciting programme of antigen discovery science linked to rapid clinical development of new vaccine candidates against malaria.
Indigenous Network Suicide Intervention Skills Training (INSIST): Can A Community Designed And Delivered Framework Reduce Suicide/self-harm In Indigenous Youth?
Funder
National Health and Medical Research Council
Funding Amount
$828,215.00
Summary
Queensland has the highest rates of youth suicide in Australia. Indigenous youth suicide rates are reported at twice the rate of Queensland’s total population for 15 to 44 years. Statistical data on urban-rural differences in Australia have only been available since 1986 (ABS, 1994). Although the number of suicides is far greater in urban areas (1,299 suicides aged 10–24 years in metropolitan areas versus 311 in towns with populations less than 4,000), rural demonstrate greater suicide rates per
Working Longer: Policy Reforms And Practice Innovations
Funder
National Health and Medical Research Council
Funding Amount
$2,162,805.00
Summary
A popular response to increased longevity is to suggest that older workers should work longer. But working longer involves changes to established policies, practices, and institutions, which are currently built around retiring earlier. The project will forecast demographic and health transition in Australia and develop capacity to analyze the likely economic and workplace adjustments that population ageing will generate. It will examine the extent to which ñworking longerî is an appropriate resp ....A popular response to increased longevity is to suggest that older workers should work longer. But working longer involves changes to established policies, practices, and institutions, which are currently built around retiring earlier. The project will forecast demographic and health transition in Australia and develop capacity to analyze the likely economic and workplace adjustments that population ageing will generate. It will examine the extent to which ñworking longerî is an appropriate response to this transition, and analyze how the labour market for older workers might evolve, taking account of individual circumstances (health, financial status, dependant care) and institutional practices (age discrimination, employment conditions, work organization), as well as regulatory and policy impacts. The overall objective of the program is to develop a multi-disciplinary knowledge base to inform integrated policy and institutional (or practice) improvement in the labour market for the elderly. Its contribution will be to improve the institutional and policy framework within which households and firms operate, with the aim of modifying workplace practices and policy and institutional constraints to encourage a more vibrant labour market for older workers. Specifically the program of research will: Assess the demographic and economic impacts of working longer under alternative policy and institutional (practice) scenarios; Provide alternative pension, superannuation, finance and taxation designs to encourage labour force participation of older people; Identify employment strategies to enhance the health and safety of older workers; Develop strategies to facilitate workforce re-entry of older workers, including gender-specific considerations; and Provide an integrated set of recommendations to create policy and practice partnerships which facilitate a labour market conducive to increased mature-age participation.Read moreRead less