A ROBOTIC MICRO DRAINAGE SURGERY FOR GLAUCOMA (A BIOLOGICAL MICROFISTULA AND IMPLANTATION METHOD AND APPARATUS)
Funder
National Health and Medical Research Council
Funding Amount
$441,020.00
Summary
Glaucoma is a major cause of blindness in our community. We are developing a new surgical procedure to treat glaucoma. The technique is based on the implantation of a tiny drainage tube inside the eye. This allows the eye's natural fluid to escape at the required rate. Insufficient drainage, or over production of fluid in the eye's of glaucoma patients is responsible for the high pressures inside the eye that characterise this disease. A simple, safe, and reliable surgical procedure to lower int ....Glaucoma is a major cause of blindness in our community. We are developing a new surgical procedure to treat glaucoma. The technique is based on the implantation of a tiny drainage tube inside the eye. This allows the eye's natural fluid to escape at the required rate. Insufficient drainage, or over production of fluid in the eye's of glaucoma patients is responsible for the high pressures inside the eye that characterise this disease. A simple, safe, and reliable surgical procedure to lower intraocular pressure would be a major benefit to the almost 67 million glaucoma patients worldwide, and would relieve the current need for lifelong medication.Read moreRead less
RNA Interference In Model Systems Of Macular Degeneration.
Funder
National Health and Medical Research Council
Funding Amount
$166,500.00
Summary
Exudative age-related macular degeneration (AMD) is the most common cause of irreversible severe vision loss in the elderly, with an estimated 25-30 million people worldwide blind due to AMD. There is currently no standard treatment for AMD. A safe, specific and effective pharmacologic agent for AMD, therefore, has enormous therapeutic, social and economic benefits. AMD is underpinned by vascular leakiness and new blood vessel formation. We have demonstrated that Egr-1, a nuclear transcription f ....Exudative age-related macular degeneration (AMD) is the most common cause of irreversible severe vision loss in the elderly, with an estimated 25-30 million people worldwide blind due to AMD. There is currently no standard treatment for AMD. A safe, specific and effective pharmacologic agent for AMD, therefore, has enormous therapeutic, social and economic benefits. AMD is underpinned by vascular leakiness and new blood vessel formation. We have demonstrated that Egr-1, a nuclear transcription factor, plays a key regulatory role in a diverse array of angiogenic processes. In this project, we will use novel gene-targeting agents (Egr-1 siRNA) to provide preclinical proof-of principle evidence of their therapeutic potential in established animal models of AMD. These studies will pre-empt Phase IA safety trials in AMD patients.Read moreRead less
A Single Digital Handheld Imaging Device For Use In Both Ophthalmology And Dentistry
Funder
National Health and Medical Research Council
Funding Amount
$431,221.00
Summary
Our aim is to produce and validate a single digital imaging device which can be used in ophthalmology (both for retinal and anterior segment imaging) and dentistry. This device will be low-cost, easy-to-operate and portable. Our planned development of the novel screening tool should help in bringing high quality, lower cost health care to those without easy access to it, firstly to residents of rural areas in Australia and then in developing countries in our region. This can be achieved by more ....Our aim is to produce and validate a single digital imaging device which can be used in ophthalmology (both for retinal and anterior segment imaging) and dentistry. This device will be low-cost, easy-to-operate and portable. Our planned development of the novel screening tool should help in bringing high quality, lower cost health care to those without easy access to it, firstly to residents of rural areas in Australia and then in developing countries in our region. This can be achieved by more efficient screening methods and redirecting resources to target those with treatable eye disease only. The detection process can be progressively transferred to less expensive health workers while ophthalmologist input can be redirected to monitoring the screening results and performing surgery. The dentists travel infrequently to rural and remote WA. If the dentist can pre plan their treatment then it will be more efficient and possible to treat more people at each visit to remote and rural WA. With the help of the proposed imaging device for dentistry, the nurses and other allied personnel should be able to send the digital images in advance to dentist over Internet and therefore help dentist pre-plan their treatment. As a result, improved dental care for rural, remote and underserved communities will occur.Read moreRead less
Web-based Multimedia Information Management System For Use In Remote Diagnosis Of Eye Diseases
Funder
National Health and Medical Research Council
Funding Amount
$196,000.00
Summary
Our aim is to develop a web-based multimedia information management system for use in remote diagnosis of eye diseases. The proposed system will provide medical advice and diagnosis, information and distance education for those working in health care as well as the community, computer-aided diagnosis and assistance in the operational and medical decision-making process. Less expensive health care personnel should be able to use the system with little training in remote and rural areas. Significa ....Our aim is to develop a web-based multimedia information management system for use in remote diagnosis of eye diseases. The proposed system will provide medical advice and diagnosis, information and distance education for those working in health care as well as the community, computer-aided diagnosis and assistance in the operational and medical decision-making process. Less expensive health care personnel should be able to use the system with little training in remote and rural areas. Significantly, the project should empower remote general doctors and nurses by proper access to expert advice, save many remote patients from unnecessary visits to specialist centres on the one hand and allow more proper diagnosis and intervention on the other. It has the potential for significant reductions in the cost of health care delivery, should strengthening the bond between medical services in remote and city areas, provide training and education of local GPs, nurses, health care workers and optometrists and provide web-based disease management systems will provide instant access to health care information. The outcomes of this project are potentially of great significance to remote and rural communities in Australia and around the world. There will be an enormous impact on current health care practices. Significantly, the project should empower remote general doctors and nurses by proper access to expert advice, save many remote patients from unnecessary visits to specialist centres on the one hand and allow more proper diagnosis and intervention on the other. It has the potential for significant reductions in the cost of health care delivery, should strengthening the bond between medical services in remote and city areas, provide training and education of local GPs, nurses, health care workers and optometrists and provide web-based disease management systems will provide instant access to health care information. The outcomes of this project are potentially of great significance to remote and rural communities in Australia and around the world. There will be an enormous impact on current health care practices.Read moreRead less
Novel System For Non-Invasive Delivery Of Drugs To The Interior Of The Eye
Funder
National Health and Medical Research Council
Funding Amount
$200,213.00
Summary
Age-related macular degeneration (AMD) is the leading cause of visual loss for adults in the developed world. Treatment is now by needle injection into the back of the eye, which is painful for the patient and is costly for the health-care system. Seagull Technology Pty Ltd has developed a non-invasive device for treating the back of the eye without the need for a needle injection. This project will test the new device in animals and then move to a first safety study for human AMD patients.
Development Of A Slit Scanning Laser Ophthalmoscope As A Screening Tool In Glaucoma Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$195,830.00
Summary
Glaucoma is typified by progressive optic disc cupping and loss of fibres with consequent characteristic field defects. Direct imaging of the retina and quantitative assessment of such images greatly increases early diagnosis of this blinding disease. The proposed device, a laser line scanning ophthalmoscope, could support non-invasive imaging to obtain 3-D information in a simple and cost effective way. This could provide objective clinical parameters to support the decision making process.