The development of a two-colour flow cytometric assay for the detection of whole cell biosensors in environmental samples. Macquarie University and the University of Copenhagen have expertise in fluorescence detection and whole cell biosensors respectively. The project will take advantage of these skills and develop a sensitive assay for monitoring biosensor bacteria in soil. The technology will be significant as it will enable real time analysis of antibiotic production in situ through the de ....The development of a two-colour flow cytometric assay for the detection of whole cell biosensors in environmental samples. Macquarie University and the University of Copenhagen have expertise in fluorescence detection and whole cell biosensors respectively. The project will take advantage of these skills and develop a sensitive assay for monitoring biosensor bacteria in soil. The technology will be significant as it will enable real time analysis of antibiotic production in situ through the detection of GFP expression. This work will then be used to isolate new antibiotic produces and will be extended to research into the bioavailability of toxic compounds and stress. An existing collaboration between the two institutions will be extended enabling the transfer and application of biosensor technology to Australia.Read moreRead less
Metabolic engineering of Zymomonas mobilis for higher value fermentation products. This project will provide an opportunity to revolutionise the Australian chemical and sugar industries. Unlike the traditional methods of the petrochemical industry, bioconversion of carbohydrates to chemicals such as succinic acid via fermentation is cosiderably environmental friendly. For the sugar industry this project will provide an opportunity to produce not only conventional sugar products but also high val ....Metabolic engineering of Zymomonas mobilis for higher value fermentation products. This project will provide an opportunity to revolutionise the Australian chemical and sugar industries. Unlike the traditional methods of the petrochemical industry, bioconversion of carbohydrates to chemicals such as succinic acid via fermentation is cosiderably environmental friendly. For the sugar industry this project will provide an opportunity to produce not only conventional sugar products but also high value commodities via the process integration of succinic acid production using agricultural residues such as bagasse. This will contribute to significant levels of job creation in Australia, and further benefits will be that such products will be important both for import replacement and export potential.Read moreRead less
Metabolic engineering to develop recombinant Zymomonas mobilis for the production of fuel ethanol and fermentation chemicals. This project will provide an opportunity to revolutionise the Australian chemical and sugar industries. Unlike the traditional methods of the petrochemical industry, bioconversion of carbohydrates to chemicals, such as succinic acid via fermentation is more considerably environmentally friendly. For the sugar industry this project will provide an opportunity to produce no ....Metabolic engineering to develop recombinant Zymomonas mobilis for the production of fuel ethanol and fermentation chemicals. This project will provide an opportunity to revolutionise the Australian chemical and sugar industries. Unlike the traditional methods of the petrochemical industry, bioconversion of carbohydrates to chemicals, such as succinic acid via fermentation is more considerably environmentally friendly. For the sugar industry this project will provide an opportunity to produce not only conventional sugar products but also high value commodities via the process integration of succinic acid production using agricultural residues, such as bagasse. This will contribute to significant levels of job creation in Australia, with the further benefit that such products will be important for both import replacement and export potential.Read moreRead less