Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
A Genome-wide Association Scan To Identify Genetic Risk Factors For Sight Threatening Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$982,203.00
Summary
Diabetic eye disease is an important complication of diabetes that can lead to blindness. Very little is known about how diabetes causes eye disease, but genetics is known to play a role. We aim to identify genes that contribute to eye disease in diabetes patients. We will compare genes between patients with diabetes with and without severe diabetic eye disease using cutting edge genomic technology. We hope to be able to better predict risk of blindness and to move towards novel treatments.
Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to pred ....Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to predict the ocean state on timescales of days to decades. This is expected to yield efficiencies in shipping, marine search and rescue and naval operations, and increase the accuracy of projected future changes in climate, sea level, ocean ecosystems and the cryosphere.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100937
Funder
Australian Research Council
Funding Amount
$373,484.00
Summary
Turbulent mixing in the deep Southern Ocean. Mixing in the Southern Ocean strongly affects the transport and storage of heat, carbon, and nutrients in the global ocean and hence climate itself. Yet processes generating mixing in the Southern Ocean remain poorly understood and inadequately represented in present ocean and climate models. This project aims to: understand mixing processes based on an innovative approach combining sparse observations and computer simulations; and to implement this u ....Turbulent mixing in the deep Southern Ocean. Mixing in the Southern Ocean strongly affects the transport and storage of heat, carbon, and nutrients in the global ocean and hence climate itself. Yet processes generating mixing in the Southern Ocean remain poorly understood and inadequately represented in present ocean and climate models. This project aims to: understand mixing processes based on an innovative approach combining sparse observations and computer simulations; and to implement this understanding into a state-of-the-art climate model to study mixing impacts on the ocean circulation and climate. This project aims to produce substantial improvements in climate models and allow Australia to predict and respond more effectively to climate change.Read moreRead less
ARC Centres of Excellence for Climate System Science. Our capacity to assess the threat of climate change is undermined by an unacceptable level of uncertainty in the understanding and modelling of regional climates. The Centre will undertake world-class research targeting identified weaknesses in the physical, chemical and biological components of the climate system. We will engage and nurture graduate students and postdoctoral follows through a program of graduate training and mentoring to per ....ARC Centres of Excellence for Climate System Science. Our capacity to assess the threat of climate change is undermined by an unacceptable level of uncertainty in the understanding and modelling of regional climates. The Centre will undertake world-class research targeting identified weaknesses in the physical, chemical and biological components of the climate system. We will engage and nurture graduate students and postdoctoral follows through a program of graduate training and mentoring to permanently transform our understanding of climate systems science particularly for the Australian region. The key outcome will be a dramatic enhancement in national capacity to understand and project the scale of future regional climate change.Read moreRead less
The Southern Ocean's response to abrupt climate change. This project aims to determine how the Southern Ocean responds to abrupt climate change, through geochemical analysis of marine sediment cores. Rapid warming events of the last ice age provide an analogue to human-caused warming. Experiments using ocean climate models will evaluate the drivers and consequences of the biogeochemical response of different sectors and zones of the Southern Ocean. The intended outcome is a better understanding ....The Southern Ocean's response to abrupt climate change. This project aims to determine how the Southern Ocean responds to abrupt climate change, through geochemical analysis of marine sediment cores. Rapid warming events of the last ice age provide an analogue to human-caused warming. Experiments using ocean climate models will evaluate the drivers and consequences of the biogeochemical response of different sectors and zones of the Southern Ocean. The intended outcome is a better understanding of how and why climate change impacts ocean productivity in the ecologically significant Southern Ocean. This will lead to better representations of carbon feedbacks in climate models and more robust projections of future climate change.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100076
Funder
Australian Research Council
Funding Amount
$394,585.00
Summary
Mixing hot spots in the Southern Ocean: processes, parameterisations and climate impacts. The Southern Ocean plays a critical role in the uptake of heat and carbon dioxide from the atmosphere into the deep ocean. This uptake depends strongly on mixing processes due to ocean eddies, which are especially important in regions of steep topography, leading to localised mixing hot spots. These ocean eddies have scales of 10-100km and therefore can not be resolved in current global climate models. This ....Mixing hot spots in the Southern Ocean: processes, parameterisations and climate impacts. The Southern Ocean plays a critical role in the uptake of heat and carbon dioxide from the atmosphere into the deep ocean. This uptake depends strongly on mixing processes due to ocean eddies, which are especially important in regions of steep topography, leading to localised mixing hot spots. These ocean eddies have scales of 10-100km and therefore can not be resolved in current global climate models. This project will examine these mixing processes using a combination of observations and innovative modelling approaches. This knowledge will be used to improve the representation of eddy processes in state-of-the-art climate models, which will ultimately allow Australia to more effectively respond to the challenge of climate change.Read moreRead less
Axon Degeneration And Axon Protection In CNS Disease And Injury
Funder
National Health and Medical Research Council
Funding Amount
$389,120.00
Summary
One of the major reasons for the clinical symptoms of neurological diseases such as Alzheimer’s disease and Motor Neuron Disease is the loss of connections between the nerve cells. Nerve cells are connected by specialized processes called axons. In disease these processes can breakdown. This project specifically looks at how axons break down in disease and tests therapeutic strategies to protect them.
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100040
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
Fast Disk Storage to Enable Big Data Science in Weather, Oceans and Climate. This project aims to expand Australia's capacity to do high-impact innovative climate, weather and oceanographic science. Science of this kind relies on massive data coupled to computationally highly intensive and complex analysis. Therefore, the project will purchase fast disk storage and install it at the National Computing Infrastructure. It is anticipated that the project will benefit the nation through better under ....Fast Disk Storage to Enable Big Data Science in Weather, Oceans and Climate. This project aims to expand Australia's capacity to do high-impact innovative climate, weather and oceanographic science. Science of this kind relies on massive data coupled to computationally highly intensive and complex analysis. Therefore, the project will purchase fast disk storage and install it at the National Computing Infrastructure. It is anticipated that the project will benefit the nation through better understanding of the climate system, including extremes; improvements in our capacity to make predictions; and through applications of the science to forecasting, the management of resources among other many other things.Read moreRead less