Brm And Brg-1 Protect From Ultraviolet Radiation-induced Skin And Ocular Damage
Funder
National Health and Medical Research Council
Funding Amount
$555,325.00
Summary
Ultraviolet radiation within sunlight is the most important environmental hazard to which Australians are exposed. It causes cancers of the skin and eye, in addition to other forms of skin and eye damage. However sunlight also has health benefits such as vitamin D production. To protect our health from the sun we need to understand how it causes damage and the meachanisms involved. We have discovered a new pathway that we plan to study, called Brm and Brg-1, that provides protection from UV.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Targeting PI3K-regulated Small Non-coding RNAs To Restore Cardiac Function
Funder
National Health and Medical Research Council
Funding Amount
$610,204.00
Summary
Heart failure affects approximately 2.4% of the adult population and over 11% of people over 80 years old. The majority of existing therapies slow, rather than reverse heart failure progression. The primary goal of this study is to determine whether regulating novel regulatory genes can enhance cardiac function in a setting of heart failure. Ultimately, technologies that target these genes may lead to innovative pharmacotherapies in the clinical management of heart failure.
Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for ....Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for heterogeneity in treatment responses, and the findings will be combined with a study of regulatory and administrative processes to support the ultimate goal of a legitimate, fair, cost-effective and responsive tax system.Read moreRead less
Using behavioural economic insights to overcome student procrastination. This project aims to study the relations between present-biased time preference, procrastination, and achievement at school, using economic experiments. Investment in human capital generates economic benefits for students, families, employers, and society, but its benefits are realised far into the future. Because of these immediate costs and delayed benefits, behavioural economic theory predicts that students will procrast ....Using behavioural economic insights to overcome student procrastination. This project aims to study the relations between present-biased time preference, procrastination, and achievement at school, using economic experiments. Investment in human capital generates economic benefits for students, families, employers, and society, but its benefits are realised far into the future. Because of these immediate costs and delayed benefits, behavioural economic theory predicts that students will procrastinate. This project will identify the characteristics of students at greatest risk of procrastination, evaluate practical strategies to overcome it, and examine whether it is associated with poorer outcomes. This should help schools and policy makers reduce educational inequalities, and yield long-term benefits over students’ lives.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101032
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental eco ....Economic analysis of peer effects in adolescence and adulthood. Although healthier, stronger and better at reasoning than young children, adolescents' morbidity and mortality rates are double those of young children. Unintentional injury, mostly avoidable and attributed to wrong decisions, is the biggest cause of death and hospitalisation among adolescents in Australia. Peer presence is likely to be a major cause of adolescents' inferior decision-making. This project aims to use experimental economics methods to study how peer presence affects the parameters of the economic decision model, specifically risk tolerance, discounting, and propensity to make errors. The project aims to advance the understanding of decision-making across the lifespan, inform theoretical modelling and advise policy-makers how to reduce the risks to adolescents.Read moreRead less
Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the l ....Strategic Behaviour in Games. John von Neumann’s minimax solution (1928) and its generalisation to mixed-strategy Nash (1950) equilibrium are the cornerstones of modern game theory, the mathematical framework for the study of decision making when the actions of different decision makers interact. This project studies human behaviour in situations where decision makers have an incentive to be unpredictable. The proposed research will shed light on the sources of the failure of the theory in the lab, and assesses the practical significance of the statistical tests used to evaluate laboratory data on mixed-strategy play.Read moreRead less
Incentivizing Attendance and Performance at School: A Field Experiment. This project aims to develop and evaluate an incentive-based program to increase the school attendance and performance of Indigenous students to help alleviate current inequalities between Indigenous and non-indigenous Australians. Only 43 per cent of Indigenous Australians graduate from high school compared to 78 per cent for non-Indigenous Australians. The study plans to investigate whether high value rewards (e.g. driving ....Incentivizing Attendance and Performance at School: A Field Experiment. This project aims to develop and evaluate an incentive-based program to increase the school attendance and performance of Indigenous students to help alleviate current inequalities between Indigenous and non-indigenous Australians. Only 43 per cent of Indigenous Australians graduate from high school compared to 78 per cent for non-Indigenous Australians. The study plans to investigate whether high value rewards (e.g. driving licence instruction) are effective in incentivising year 11 and 12 students. It also aims to examine whether the way incentives are provided — ex-post as traditionally done or ex-ante in the form of a trust-based contract — increase high school completion rates of Indigenous students where previous incentive schemes have failed.Read moreRead less
Introspection, Learning, and Equilibrium in Games: Theory and Experiment. Game theory is increasingly being used in the social sciences, but the extreme reliance on perfect decision making and perfect foresight has raised doubts about its empirical relevance. This scepticism is reinforced by laboratory evidence showing behaviour patterns that are systematically biased away from game-theoretic predictions. This project concerns the development and testing of models more descriptive of actual huma ....Introspection, Learning, and Equilibrium in Games: Theory and Experiment. Game theory is increasingly being used in the social sciences, but the extreme reliance on perfect decision making and perfect foresight has raised doubts about its empirical relevance. This scepticism is reinforced by laboratory evidence showing behaviour patterns that are systematically biased away from game-theoretic predictions. This project concerns the development and testing of models more descriptive of actual human behaviour. One aim is to deliver hybrid models able to reproduce interesting patterns of first-period play (introspection), time-series data in repeated games (learning), and systematic departures from static equilibrium. Another aim is to apply a successful hybrid to improve the design of economic and social institutions.Read moreRead less
Nobody knows anything? Applying pari-mutuel prediction markets to the motion picture industry. This project will explore the predictability of unreleased motion pictures' theatrical box office revenues using incentive rich pari-mutuel prediction markets. The mechanism will promote price discovery and associated probability estimates that will benefit those already investing in the industry as well as encouraging new investment.