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The Pacific OPIC Study - A Four Country Study Of Obesity Prevention In Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,600,580.00
Summary
Obesity is a rapidly escalating, worldwide epidemic. Many countries recognise the need to prevent obesity but there is insufficient evidence about what interventions work. The Pacific Obesity Prevention in Communities (OPIC) Project will provide data on the effectiveness of a range of interventions to prevent obesity among young people in Fiji, Tonga, New Zealand and Australia. Prevention research is particularly required in countries such as Fiji and Tonga because their prevalence of obesity is ....Obesity is a rapidly escalating, worldwide epidemic. Many countries recognise the need to prevent obesity but there is insufficient evidence about what interventions work. The Pacific Obesity Prevention in Communities (OPIC) Project will provide data on the effectiveness of a range of interventions to prevent obesity among young people in Fiji, Tonga, New Zealand and Australia. Prevention research is particularly required in countries such as Fiji and Tonga because their prevalence of obesity is extremely high. The interventions used in this project will be culturally appropriate and include at least 1000 young people in each intervention group. The outcomes of this project will be applicable to both low- and high-income countries. This project will lead to a greater understanding of the socio-cultural, policy, and economic contexts and provide crucial evidence for public health action to prevent obesity.Read moreRead less
EuropeaN Energy Balance Research To Prevent Excessive Weight Gain Among Youth: The ENERGY Study
Funder
National Health and Medical Research Council
Funding Amount
$102,209.00
Summary
The objective of the ENERGY project is to examine the influence of existing programs on health behaviours in different populations and settings in order to develop an evidence and theory-based approach for promoting physical activity and healthy eating among youth in transition from childhood to adolescence. The results of this project will be translated into practical strategies and knowledge that can be used by schools, policymakers, health professionals and the general public. The ENERGY proj ....The objective of the ENERGY project is to examine the influence of existing programs on health behaviours in different populations and settings in order to develop an evidence and theory-based approach for promoting physical activity and healthy eating among youth in transition from childhood to adolescence. The results of this project will be translated into practical strategies and knowledge that can be used by schools, policymakers, health professionals and the general public. The ENERGY project involves a multidisciplinary team of investigators from 10 European countries and Australia (Deakin University; DU). DU will participate in two of the 10 work packages (WP) in the proposal. The aim of WP3 is to identify the personal, social and physical environmental determinants in family and school of children’s physical activity and healthy eating. The aim of WP5 is to identify moderators and mediators of successful interventions to prevent obesity among children aged 10-12 years.Read moreRead less
Study Of HPV 6 L1 Virus Like Paticles As Therapeutic Vaccine For Genital Warts And Recurrent Respiratory Papillomatosis.
Funder
National Health and Medical Research Council
Funding Amount
$615,608.00
Summary
This project will examine the effectiveness of a vaccine designed to prevent tumours and cancers associated with papillomarvirus infection as treatment for existing infections, and will look for predictors of a favourable outcome from treatment.
Osteoporosis is a common condition in which bone strength is reduced due to reduced amount and quality of bone. Reduced bone strength means an increased risk of fracture. Osteoporotic fractures occur in 1 in 2 women and 1 in 3 men in their lifetime, and the likelihood of suffering osteoporotic fracture increases with age. Most of the risk of developing osteoporosis is genetic, but few of the genes involved have been identified. Our goal is to identify those genes. We will complete recruitment an ....Osteoporosis is a common condition in which bone strength is reduced due to reduced amount and quality of bone. Reduced bone strength means an increased risk of fracture. Osteoporotic fractures occur in 1 in 2 women and 1 in 3 men in their lifetime, and the likelihood of suffering osteoporotic fracture increases with age. Most of the risk of developing osteoporosis is genetic, but few of the genes involved have been identified. Our goal is to identify those genes. We will complete recruitment and assessment of a cohort of 1500 postmenopausal women with either low or high bone mineral density from pre-existing population cohorts in Australia. A genomewide association study will then be performed on these cases. Associated genes in different datasets will then be investigated further in our cohort, and high-density SNP mapping performed to identify true associated variants. These studies should identify most genetic variants associated with BMD variation and low trauma fracture in the general community, allowing development of diagnostic-disease predictive genetic tests, and informing development of novel therapeutic agents for osteoporosis.Read moreRead less
Alternative Medicines From Medicinal Plants Of Aboriginal People Of Northern New South Wales
Funder
National Health and Medical Research Council
Funding Amount
$150,400.00
Summary
This research will conserve customary Australian Aboriginal knowledge of historical and cultural significance and apply this knowledge to the discovery of new evidence-based alternative medicines that may help address the growing need for new antimicrobial treatments. It will also be a model for collaboration between Australian Aboriginal communities and research scientists. The customary (traditional and contemporary) knowledge of medicinal plants possessed by Indigenous peoples is a significan ....This research will conserve customary Australian Aboriginal knowledge of historical and cultural significance and apply this knowledge to the discovery of new evidence-based alternative medicines that may help address the growing need for new antimicrobial treatments. It will also be a model for collaboration between Australian Aboriginal communities and research scientists. The customary (traditional and contemporary) knowledge of medicinal plants possessed by Indigenous peoples is a significant medicinal resource, as seen by the reliance on customary medicines by ~80% of the population in developing countries as their primary healthcare. There has been a renewed interest in customary medicines, especially with the increase in microbial resistance and emergence of new diseases, side effects of single compound medications and high cost of drug development. Australian Aboriginal people have a vast medicinal plant knowledge based on thousands of years of using plants as medicines. This especially includes topical use for conditions indicative of microbial infections. Despite their potential, relatively few studies have been conducted on Australian Aboriginal medicines to provide evidence for their use. For Northern New South Wales (NNSW) Aboriginal communities, as is the case for many other Australian Aboriginal communities, this customary knowledge is rapidly disappearing, especially due to premature deaths of the elder custodians of this knowledge. The overall aims of this project are to work in partnership with the NNSW Yaegl Local Aboriginal Land Council and Ulgundahi Elders Aboriginal Corporation to i) document and preserve first hand customary medicinal plant knowledge; ii) identify plants of significant medicinal potential in treating antibacterial and antifungal infections; iii) evaluate their effectiveness using in vitro and in vivo biological assays; and iv) identify the major bioactive components responsible for their medicinal properties.Read moreRead less
Preventing Obesity Among Socioeconomically Disadvantaged Women And Children
Funder
National Health and Medical Research Council
Funding Amount
$2,072,674.00
Summary
The research will investigate the causes of the increased risk of obesity among socioeconomically disadvantaged women and children. It will also focus on women and children who appear �resilient� to obesity and will explore the possibility of applying the lessons learned to other women and children, in order to help support them in adopting and maintaining obesity-protective behaviours. The research aims to provide evidence to inform policies and programs that should be put into place to prevent ....The research will investigate the causes of the increased risk of obesity among socioeconomically disadvantaged women and children. It will also focus on women and children who appear �resilient� to obesity and will explore the possibility of applying the lessons learned to other women and children, in order to help support them in adopting and maintaining obesity-protective behaviours. The research aims to provide evidence to inform policies and programs that should be put into place to prevent obesity among socioeconomically disadvantaged groups.Read moreRead less
Primary Care: What Is Their Approach To Patients With Advanced Cancer And Those Who Require Radiotherapy
Funder
National Health and Medical Research Council
Funding Amount
$50,000.00
Summary
It is recommended that 50-60% of all cancer patients receive radiotherapy at some time in their disease. However, only 38% of all cancer patients receive radiotherapy in Australia. Advanced cancer patients may be missing out on radiotherapy because they are not referred for palliative radiotherapy. The specific aims of this study are to: Explore the primary care approach to patients with advanced cancer and particularly those who require radiotherapy; Define factors that influence how Australian ....It is recommended that 50-60% of all cancer patients receive radiotherapy at some time in their disease. However, only 38% of all cancer patients receive radiotherapy in Australia. Advanced cancer patients may be missing out on radiotherapy because they are not referred for palliative radiotherapy. The specific aims of this study are to: Explore the primary care approach to patients with advanced cancer and particularly those who require radiotherapy; Define factors that influence how Australian GPs respond to symptoms of advanced cancer; Map the patients’ perspective on current referral practice for palliative care. This project will be comprised of three stages: simulated consultations with GPs, survey of GPs and patient interviews. These methods will enable researchers to develop an understanding of the primary care approach to patients with advanced cancer and those who require radiotherapy and how patients with advanced disease are referred for treatment.Read moreRead less
Body Composition Changes In Cardiac Cachexia: Pathophysiology, Quantification And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$120,000.00
Summary
Cachexia is weight loss and weakness caused by disease, or as a side effect of illness. Congestive heart failure is a common cardiovascular condition that is accompanied by high mortality (up to 50% over 2 years) and considerable suffering. People with congestive heart failure often develop cachexia. This project will explore the mechanisms responsible for the development of cachexia using an animal model of cardiac cachexia that the researchers have developed. It will be complemented by an exam ....Cachexia is weight loss and weakness caused by disease, or as a side effect of illness. Congestive heart failure is a common cardiovascular condition that is accompanied by high mortality (up to 50% over 2 years) and considerable suffering. People with congestive heart failure often develop cachexia. This project will explore the mechanisms responsible for the development of cachexia using an animal model of cardiac cachexia that the researchers have developed. It will be complemented by an examination of the effects of exercise on measures of cachexia in patients with congestive heart failure. The researchers believe that this study will supply valuable new information about the development of cachexia and lead to new therapies for this syndrome.Read moreRead less