Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100186
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes ....The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes of this project include new discoveries in fields such as nanotechnology, photonics, robotics, metamaterials, biosurface engineering or biotechnology. This should provide significant benefits, such as placing Australia in the leadership of nanotechnology and additive manufacturing.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100796
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Superior Adsorption Capability of Nanosheets for Surface Enhanced Raman. This project aims to create nanotechnologies to sense traces of chemical and biological molecules. Surface adsorption is vital to many scientific and industrial fields, but the intrinsic adsorption property of two-dimensional nanomaterials is largely unknown. This project aims to examine the adsorption capability of nanosheets, such as boron nitride, and understand the thickness effect on their adsorption at the molecular s ....Superior Adsorption Capability of Nanosheets for Surface Enhanced Raman. This project aims to create nanotechnologies to sense traces of chemical and biological molecules. Surface adsorption is vital to many scientific and industrial fields, but the intrinsic adsorption property of two-dimensional nanomaterials is largely unknown. This project aims to examine the adsorption capability of nanosheets, such as boron nitride, and understand the thickness effect on their adsorption at the molecular scale. It also aims to demonstrate the use of these nanosheets as substrates in surface-enhanced Raman spectroscopy. Their adsorption capability and other unique properties could improve the sensitivity, efficiency and affordability of this technique in chemical and biological sensing for applications such as air, water and food safety; and pharmaceutical and cosmetic industries.Read moreRead less
Novel link between bacterial sugar metabolism and cell-to-cell signalling. This project aims to understand the role and function of the bacterial communication system that enables bacteria to form complex communities and alter phenotypic traits, essential for survival in their environment. Bacteria survive in their environmental niches by developing complex multicellular communities. Cell to cell communication, termed quorum sensing (QS), is critical for this process and is linked to their capac ....Novel link between bacterial sugar metabolism and cell-to-cell signalling. This project aims to understand the role and function of the bacterial communication system that enables bacteria to form complex communities and alter phenotypic traits, essential for survival in their environment. Bacteria survive in their environmental niches by developing complex multicellular communities. Cell to cell communication, termed quorum sensing (QS), is critical for this process and is linked to their capacity to detect and secrete small signalling molecules, autoinducers. This project will provide a new paradigm in bacterial adaptation through comprehensive characterisation of the Autoinducer-2 QS system. This knowledge will provide future opportunities for intervention in microbial infestation with broad potential benefits.Read moreRead less
Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performi ....Trapping and Watching Biomolecular Complexes near Nanopores. This project aims to develop a technology to trap and interrogate nanosized molecular complexes in their natural state. Nanosized complexes in water provide the core machinery of biological systems and require detailed understanding to help unravel fundamental biological mechanisms. A prototype of a methodology has been developed to trap and interrogate nanoscaled objects as small as 190 nanometres within a nanopore device. By performing research to fully understand, miniaturise and develop this method further, this project aims to enable the quantitative observation of nanoscaled biological machinery involved in cell-to-cell communication and DNA unfolding. Such a technology platform may have applications in areas such as biology, biotechnology and advanced materials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100986
Funder
Australian Research Council
Funding Amount
$401,000.00
Summary
High-performance, portable ion-mobility surface-acoustic wave spectrometry. This project aims to develop a high-performance, cost-effective, palm-portable differential ion mobility spectrometer for universal chemical analysis that operates at atmospheric pressure and consumes minimal power. A significant problem in current analytical chemistry is the lack of rapid and cost-effective methods that can be used in the field for analysis of many different chemical species of environmental and biologi ....High-performance, portable ion-mobility surface-acoustic wave spectrometry. This project aims to develop a high-performance, cost-effective, palm-portable differential ion mobility spectrometer for universal chemical analysis that operates at atmospheric pressure and consumes minimal power. A significant problem in current analytical chemistry is the lack of rapid and cost-effective methods that can be used in the field for analysis of many different chemical species of environmental and biological importance. The project expects to enable the rapid and simultaneous separation and detection of many different ions from complex mixtures with high selectivity and sensitivity. The spectrometer can be implemented in the field for various applications such as atmospheric monitoring, disease diagnosis and chemical weapons detection.Read moreRead less
The development of novel and tunable metamaterials. Metamaterials are designed materials with properties that cannot be found in nature. This project uses a new disruptive design that allows broadband metamaterials to be made using mass production techniques. The design opens up a range of new applications in environmental and medical sensing, improved security screening and active devices.
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the r ....Cell Membrane Coated Photonic Crystal to study Receptor-Ligand Interactions. The current gold-standard assays for examining receptor-ligand interactions require expensive and costly fluorescent or radioactive labels or proteomics processes. This project aims to develop Artificial Photonic Cells by directly coating photonic crystals with cell membranes. The Artificial Photonic Cells retain the protein receptors in their native cell membrane environment and allow for label-free monitoring of the receptor-ligand interactions using inexpensive miniature spectrometers - radically transforming these assays. This would generate fundamental and applied knowledge of materials sciences, photonic, and biointerfaces for label-free, ultra-sensitive, and selective assays to enable future drug and diagnostics target discovery. Read moreRead less