Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101441
Funder
Australian Research Council
Funding Amount
$322,446.00
Summary
A new approach for characterising soils based on electric parameters. This project aims to develop a predictive methodology based on electromagnetic sensors to quantify soil state variables that influence hydraulic and mechanical processes. These processes affect the safety of man-made and natural geo-structures such as dams or embankments. Conventional monitoring methods are outdated and unreliable, reducing our capability of detecting threats to these structures. The outcomes of the project wi ....A new approach for characterising soils based on electric parameters. This project aims to develop a predictive methodology based on electromagnetic sensors to quantify soil state variables that influence hydraulic and mechanical processes. These processes affect the safety of man-made and natural geo-structures such as dams or embankments. Conventional monitoring methods are outdated and unreliable, reducing our capability of detecting threats to these structures. The outcomes of the project will improve protection of major geo-structures, trigger novel applications in civil engineering and foster the development of patentable sensors and data analysis methodology.Read moreRead less
Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microflu ....Platform technologies for multifunctional nanocarrier systems. Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.Read moreRead less
Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising mat ....Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising material for the semiconductor. However, unmodified TiO2 only absorbs ultraviolet light (5 per cent of solar energy). With current progress made in visible absorbance, this project aims to significantly improve TiO2’s absorbance in near infrared by doping with upconversion lanthanides and rendering colloidal crystal suprastructures that can trap light.Read moreRead less
Progressive collapse resistance of concrete flat plate structures. This project aims to systematically and thoroughly investigate the progressive collapse mechanisms and resistance capacity of concrete flat plate structures. They represent one of the most common construction systems used worldwide in modern days, yet their progressive collapse mechanisms require attention and limited collapse prevention design guidelines are available. The outcomes are expected to broaden and deepen the existing ....Progressive collapse resistance of concrete flat plate structures. This project aims to systematically and thoroughly investigate the progressive collapse mechanisms and resistance capacity of concrete flat plate structures. They represent one of the most common construction systems used worldwide in modern days, yet their progressive collapse mechanisms require attention and limited collapse prevention design guidelines are available. The outcomes are expected to broaden and deepen the existing theoretical framework and knowledge base, prevent injury and loss of life in both new and existing buildings. This is expected ultimately to contribute to the establishment of a set of collapse-resistant design guidelines for further development of relevant Australian and international standards.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100229
Funder
Australian Research Council
Funding Amount
$293,920.00
Summary
Ultra-low field magnetic resonance imaging with an array of localised magnetic field sensor . The aim of this project is to design and construct a multifunctional ultra-low magnetic field (ULF) magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) instrument equipped with novel magnetic field sensors. This project is significant because it will deliver an instrument with enhanced sensitivity which is capable of obtaining non-invasive three-dimensional structural imaging of sample ....Ultra-low field magnetic resonance imaging with an array of localised magnetic field sensor . The aim of this project is to design and construct a multifunctional ultra-low magnetic field (ULF) magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) instrument equipped with novel magnetic field sensors. This project is significant because it will deliver an instrument with enhanced sensitivity which is capable of obtaining non-invasive three-dimensional structural imaging of samples. This instrument will enable operation of highly sensitive ULF-MRI or ULF-NMR with regenerative energy sources and be a low-cost solution; reducing operation and maintenance costs as well as power consumption.Read moreRead less
Magnetofluidic sample handling for enhanced point-of-care diagnosis. This project aims to decipher the mechanism behind recent discovery on the enhancement of mixing and separation with magnetism and to apply it to the rapid and early detection of malaria and cancer. This mechanism provides novel and unique fluid handling capabilities, which allow the development of revolutionary point-of-care diagnostic approaches that integrate magnetic mixing, separation and detection on a single device. The ....Magnetofluidic sample handling for enhanced point-of-care diagnosis. This project aims to decipher the mechanism behind recent discovery on the enhancement of mixing and separation with magnetism and to apply it to the rapid and early detection of malaria and cancer. This mechanism provides novel and unique fluid handling capabilities, which allow the development of revolutionary point-of-care diagnostic approaches that integrate magnetic mixing, separation and detection on a single device. The outcomes of this project are instrumental for the reduction of healthcare cost, promoting good health for Australian and potentially creating new jobs in the niche biomedical industry.Read moreRead less
Development of Intelligent Structures that can Self-evaluate Deterioration. This project aims to transform traditional civil structures into smart structures that can accurately identify current and future structural deterioration conditions and automatically notify the infrastructure management authority for timely maintenance. Civil structures deteriorate over their long life spans. Currently, we have no effective method to identify when deterioration has reached the point where maintenance is ....Development of Intelligent Structures that can Self-evaluate Deterioration. This project aims to transform traditional civil structures into smart structures that can accurately identify current and future structural deterioration conditions and automatically notify the infrastructure management authority for timely maintenance. Civil structures deteriorate over their long life spans. Currently, we have no effective method to identify when deterioration has reached the point where maintenance is required. The project plans to develop innovative structural deterioration evaluation systems using output-only vibration data and versatile optimisation algorithms to enable long-term deterioration assessment and maintenance management even under demanding operating conditions. These could be used with both conventional data acquisition systems and modern monitoring systems with smart wireless sensors. Expected project outcomes will enhance structural safety and maintenance efficiency.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101550
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Functional polymer encapsulation to enhance biological performance of implantable materials. This project will develop biomaterial films from essential oils using a low-cost 'green' technology. Applied to commercial biomaterials, these films will minimise infections and inflammations commonly associated with implants. These films will also enable clinical use of metallic resorbable implants for tissue engineering and function restoration.