Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system ....Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.Read moreRead less
Unravelling the mysteries of turbulent drag at the air-sea interface. 70% of the Earth's surface is the air-sea interface. A huge amount of energy and gas is exchanged between the atmosphere and ocean; exchanges that are crucial for life on earth. Climate models, weather and wave forecasts depend on oversimplified models for these exchanges. Oversimplification limits accuracy, with outcomes ranging from inaccurate climate predictions to costly and unnecessary rerouting of ships or evacuations of ....Unravelling the mysteries of turbulent drag at the air-sea interface. 70% of the Earth's surface is the air-sea interface. A huge amount of energy and gas is exchanged between the atmosphere and ocean; exchanges that are crucial for life on earth. Climate models, weather and wave forecasts depend on oversimplified models for these exchanges. Oversimplification limits accuracy, with outcomes ranging from inaccurate climate predictions to costly and unnecessary rerouting of ships or evacuations of oil platforms. This project promises new knowledge of the turbulent air flow above waves through innovative, ambitious experiments in our laboratory wind-wave tanks. Concurrently, novel numerical simulations will enable new models for sea drag coefficient, the most critical component in air-sea interaction models. Read moreRead less
Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising mat ....Capturing full-spectrum of solar energy using TiO2 ordered suprastructures. The project aims to develop a titanium dioxide (TiO2) semiconductor that can use full-spectrum solar energy. Solar-driven photocatalytic processes have important applications in water decontamination and energy production. Their effectiveness is dictated by the semiconductor’s absorbance and conversion of photoenergy to chemical energy. Being inexpensive, chemically and mechanically robust, TiO2 is the most promising material for the semiconductor. However, unmodified TiO2 only absorbs ultraviolet light (5 per cent of solar energy). With current progress made in visible absorbance, this project aims to significantly improve TiO2’s absorbance in near infrared by doping with upconversion lanthanides and rendering colloidal crystal suprastructures that can trap light.Read moreRead less
Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment an ....Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.Read moreRead less
Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulation ....Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulations of movement using realistic models of muscle and joint anatomy. This project expects to create the next generation of methods and algorithms needed to enable predictive modelling of movement. Predictive simulations will provide new insights into how muscles stabilise and control movements of the spine, pelvis and lower limbs during daily activities such as walking.Read moreRead less
Developing novel two-dimensional hybrid nanostructures for renewable energy. This project aims to develop novel two-dimensional (2D) hybrid nanostructures with new physical and chemical properties. This innovation intends to address the critical challenges of control functionalisation of 2D hybrid nanostructures: essential to understanding the potential of nanomaterials in key applications of energy generation. Expected outcomes include scalable technology to produce functional 2D nanomaterials ....Developing novel two-dimensional hybrid nanostructures for renewable energy. This project aims to develop novel two-dimensional (2D) hybrid nanostructures with new physical and chemical properties. This innovation intends to address the critical challenges of control functionalisation of 2D hybrid nanostructures: essential to understanding the potential of nanomaterials in key applications of energy generation. Expected outcomes include scalable technology to produce functional 2D nanomaterials and hybrid nanostructures to accelerate research to advanced materials and frontier material manufacturing technologies. This project will provide significant social and economic benefits to Australia in the growth of sectors in advanced materials, energy generation, and advanced manufacturing.Read moreRead less
Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims ....Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims to exploit the adhesive nature of metal–phenolic materials to rapidly coat diverse surfaces, including stainless steel and textiles. The expected outcome is the generation of antimicrobial polypeptide surfaces, which will have benefits in food safety, medical implant technology and advanced textiles.Read moreRead less
Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and pl ....Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and planning of engineering processes in fractured porous media will be increased to the point that costly over/under designs are avoided. Through the use of the tools developed, it will be possible to detect weaknesses in the design, assess the impact and implement effective measures to improve performance.Read moreRead less
New frontiers in ultra-wideband electro-optic measurement technologies. The project will lead to new frontier technologies for scientific instrumentation with greatly improved accuracies and ultra wide bandwidth capability with outcomes enhancing Australia's research profile in measurement science. New capabilities developed will benefit areas such as neuroscience, high-speed electronic circuitry designs and imaging.
Nanophotonic pixels for subwavelength imaging on a chip. This project aims to develop a nanophotonic pixel technology in complementary metal-oxide semi-conductor (CMOS) chips to bypass the resolution limitations for direct optical imaging and enumeration of submicron sized specimens in lab-on-chip imaging applications. Lab-on-chip imaging technology is a promising point-of-care technology, where the specimen is placed directly on a CMOS chip for imaging without using labels or chemicals and with ....Nanophotonic pixels for subwavelength imaging on a chip. This project aims to develop a nanophotonic pixel technology in complementary metal-oxide semi-conductor (CMOS) chips to bypass the resolution limitations for direct optical imaging and enumeration of submicron sized specimens in lab-on-chip imaging applications. Lab-on-chip imaging technology is a promising point-of-care technology, where the specimen is placed directly on a CMOS chip for imaging without using labels or chemicals and with no intervening optical components. The technology arising from the research will ultimately allow new devices to be developed, expanding the uses for lab-on-chip and potentially changing the way in which front-line medicine is practiced.Read moreRead less