Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
How do mechanics, neural drive and muscle architecture interact in muscles? This project will determine how an individual person’s muscle activity, muscle structure and mechanical properties, and the local mechanical conditions around the muscle interact as muscles move and deform, by using experiments and personalised computational models that can examine these factors and their interactions concurrently. To achieve this, we will develop novel magnetic resonance imaging methods to measure the m ....How do mechanics, neural drive and muscle architecture interact in muscles? This project will determine how an individual person’s muscle activity, muscle structure and mechanical properties, and the local mechanical conditions around the muscle interact as muscles move and deform, by using experiments and personalised computational models that can examine these factors and their interactions concurrently. To achieve this, we will develop novel magnetic resonance imaging methods to measure the mechanical properties of muscles in humans and methods for modelling muscles. As well as answering fundamental scientific questions about muscle function, these new techniques will provide a platform for studying other muscles, and for future development of muscle training methods and technologies to optimise muscle function.Read moreRead less
Seeing the Bio-Nano "Talk" in the brain via real-time multiplex tracking. This project aims to develop new knowledge and smart tools that have the potential to greatly improve brain research. The blood-brain-barrier is the major physiological barrier that protects the brain from environmental toxins, bacteria and viruses, but limits the effectiveness of nanoparticle-based brain imaging agents. Expected outcomes of this project include a better understanding of the mechanisms that allow nanoparti ....Seeing the Bio-Nano "Talk" in the brain via real-time multiplex tracking. This project aims to develop new knowledge and smart tools that have the potential to greatly improve brain research. The blood-brain-barrier is the major physiological barrier that protects the brain from environmental toxins, bacteria and viruses, but limits the effectiveness of nanoparticle-based brain imaging agents. Expected outcomes of this project include a better understanding of the mechanisms that allow nanoparticles to penetrate the blood-brain-barrier, as well as improving brain imaging. Benefits of the project include the commercialisation of technologies and smarl tools developed in this projetct, and establishment of a new Australian biotechnology company that exports brain-imaging technologies to the world.Read moreRead less
Nano optoelectronic coupling: towards an ultrasensitive sensing technology. This project aims to elucidate ultrasensitive mechanical and thermal sensing effects that are tens of thousands of times better than conventional sensing technologies. This is achieved through controlling interactions between photons and electrons at the interface of two semiconductors. Outcomes of this project include scientific breakthroughs that are expected to revolutionise and disrupt the established sensing technol ....Nano optoelectronic coupling: towards an ultrasensitive sensing technology. This project aims to elucidate ultrasensitive mechanical and thermal sensing effects that are tens of thousands of times better than conventional sensing technologies. This is achieved through controlling interactions between photons and electrons at the interface of two semiconductors. Outcomes of this project include scientific breakthroughs that are expected to revolutionise and disrupt the established sensing technologies. Microscopic low power mechanical and thermal sensors with ultra-high sensitivity have great value to enhance safety, security, and productivity of industry and society. The project is expected to generate new knowledge and place Australia as the world leader in physical sensing and create a new industry.Read moreRead less
Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system ....Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Modelling surface stresses in crystalline plates. This project intends to improve our understanding of the influence of surface stress on bending in anisotropic crystalline plates. Micro/nanoelectro-mechanical systems as transducers, switches, logic gates, actuators and sensors are widely used in fields of biotechnology, medicine, automotive, civionics, avionics and defence. A key issue that affects the accuracy and reliability of these systems is how to correctly predict the size-dependent surf ....Modelling surface stresses in crystalline plates. This project intends to improve our understanding of the influence of surface stress on bending in anisotropic crystalline plates. Micro/nanoelectro-mechanical systems as transducers, switches, logic gates, actuators and sensors are widely used in fields of biotechnology, medicine, automotive, civionics, avionics and defence. A key issue that affects the accuracy and reliability of these systems is how to correctly predict the size-dependent surface stress of the structural components in the systems. The project aims to quantify the relations between the change in surface stress and the bending of structures with micro/nanoscale thickness and arbitrary crystallographic symmetry. Expected project outcomes may lead to significant advancement in overcoming the current shortcomings in designing micro/nanoelectro-mechanical devices.Read moreRead less
Biologically Inspired Binaural Coupling for Selective Machine Hearing. This project aims to investigate biologically-inspired binaural coupling models in the context of the deep learning paradigm by formulating desirable higher level auditory structures as neural network sub-systems. This project expects to generate new knowledge for developing the next generation of robust speech processing systems that are capable of mimicking the selecting listening ability of humans when faced with realistic ....Biologically Inspired Binaural Coupling for Selective Machine Hearing. This project aims to investigate biologically-inspired binaural coupling models in the context of the deep learning paradigm by formulating desirable higher level auditory structures as neural network sub-systems. This project expects to generate new knowledge for developing the next generation of robust speech processing systems that are capable of mimicking the selecting listening ability of humans when faced with realistic noisy speech signals and the ‘cocktail party problem’ using innovative binaural feedback systems. This work should provide significant benefits, including improved voice biometrics and selective auditory attention capabilities in machines.Read moreRead less
Integrating biologically-inspired auditory models into deep learning. This project aims to discover how a biologically inspired auditory model can be tightly integrated into a state-of-the-art deep learning speech processing framework, to model, design and verify a deep learning based auditory model. Voice-based technologies, ranging from cochlear implants to smart homes, are growing at a rapid pace and speech interfaces are being integrated with all aspects of our lives. However, there is a gro ....Integrating biologically-inspired auditory models into deep learning. This project aims to discover how a biologically inspired auditory model can be tightly integrated into a state-of-the-art deep learning speech processing framework, to model, design and verify a deep learning based auditory model. Voice-based technologies, ranging from cochlear implants to smart homes, are growing at a rapid pace and speech interfaces are being integrated with all aspects of our lives. However, there is a growing demand to improve these voice-enabled services, making them more secure and less open to cyber-crime attack by unauthorised users. The project is expected to improve techniques for modelling and automatic processing of speech and audio signals, which should provide significant benefits, including improved voice biometrics and cochlear implants.Read moreRead less
Active Sound Control and Noise Cancellation over Space. This project aims to address the critical issues for creating acoustic quiet zones in a noisy environment. It will provide novel signal processing theory for further development of active noise cancellation techniques over spatial regions. New technologies developed from this project are expected to underpin the future development of acoustic signal processing research and will have a broad range of applications such as reduction of noise i ....Active Sound Control and Noise Cancellation over Space. This project aims to address the critical issues for creating acoustic quiet zones in a noisy environment. It will provide novel signal processing theory for further development of active noise cancellation techniques over spatial regions. New technologies developed from this project are expected to underpin the future development of acoustic signal processing research and will have a broad range of applications such as reduction of noise inside cars, creation of individual quiet zones in passenger planes and mitigation of acoustic noise made by industrial plants to neighbouring suburbs. The outcomes from this proposal will also have economic importance as it can reduce the health risk posed to people working or living in noisy environments.Read moreRead less