Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to disco ....Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.Read moreRead less
Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliv ....Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliver the knowledge to underpin effective psychological safety and mental health guidelines for community sports with national impact. When implemented, this knowledge will help sports clubs to provide a psychologically safe environment, and promote the mental health and wellbeing of all Australians involved in organised sports.Read moreRead less
Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans re ....Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans respond to changing environments during their lifetime, and will underpin the development of evidence-based personalised health interventions to keep Australians healthier for longer.
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Outcomes of specialist disability housing for people with disability. This project aims to systematically investigate the experience, outcomes and economic impact of people with disability moving into specialist disability accommodation housing. Health, wellbeing, community participation, support outcomes and lived experience of people with disability will be measured before moving and over 2 years after they move. The project provides the opportunity to identify the personal, disability, housi ....Outcomes of specialist disability housing for people with disability. This project aims to systematically investigate the experience, outcomes and economic impact of people with disability moving into specialist disability accommodation housing. Health, wellbeing, community participation, support outcomes and lived experience of people with disability will be measured before moving and over 2 years after they move. The project provides the opportunity to identify the personal, disability, housing and support factors that shape outcomes for people with disability. The intended outcome is comprehensive knowledge that can inform policy, build evidence across housing, technology, support and disability sectors and ultimately benefit people with disability by generating innovative practice in housing and support.Read moreRead less
Molecular networks underlying mitochondrial biogenesis in humans. Mitochondria are essential for life, and we propose a highly-innovative approach (employing multiple, cutting-edge ‘omic’ technologies and bioinformatics) to advance the fundamental understanding of how mitochondria respond and adapt to exercise in humans. The project outcomes should include significant new knowledge and advanced expertise that can be used by others to facilitate additional research outcomes. The project anticipa ....Molecular networks underlying mitochondrial biogenesis in humans. Mitochondria are essential for life, and we propose a highly-innovative approach (employing multiple, cutting-edge ‘omic’ technologies and bioinformatics) to advance the fundamental understanding of how mitochondria respond and adapt to exercise in humans. The project outcomes should include significant new knowledge and advanced expertise that can be used by others to facilitate additional research outcomes. The project anticipates the contribution of innovative tools for molecular biology research, benefiting therapeutic and biotechnology applications. This project will support advanced training of young researchers in frontier technologies, which will expand Australian research capabilities and help produce a higher quality workforce.Read moreRead less
Researching an all-of-family program in family violence & substance misuse. Family violence services and drug and alcohol services have been inappropriately siloed given co-occurrence of these problems is common. This project aims to evaluate an innovative program which integrates these services, focuses on fathering to ensure recognition of the needs of children (50% of family violence victims) and provides all-of-family support to ensure the safety and well-being of women and children. Expect ....Researching an all-of-family program in family violence & substance misuse. Family violence services and drug and alcohol services have been inappropriately siloed given co-occurrence of these problems is common. This project aims to evaluate an innovative program which integrates these services, focuses on fathering to ensure recognition of the needs of children (50% of family violence victims) and provides all-of-family support to ensure the safety and well-being of women and children. Expected outcomes include better evidence for countering family violence, and policy frameworks for integrated service provision. Changing the behaviour of men who use violence is a significant social challenge and the outcomes of this targeted approach should have ramifications nationally and internationally. Read moreRead less
Reducing the harms associated with conscientious objection to abortion. This project aims to critically evaluate the regulation of conscientious objection to abortion. A range of state-based laws regulate this practice in Australia, and there is evidence that all result in inequitable access, harms to women and lack clarity for providers. The project will critically evaluate the legal and regulatory options for managing conscientious objection and interview conscientious objectors to develop a c ....Reducing the harms associated with conscientious objection to abortion. This project aims to critically evaluate the regulation of conscientious objection to abortion. A range of state-based laws regulate this practice in Australia, and there is evidence that all result in inequitable access, harms to women and lack clarity for providers. The project will critically evaluate the legal and regulatory options for managing conscientious objection and interview conscientious objectors to develop a conceptual model to explain their practices. A participatory process with experts will identify the optimal model for regulation and how to translate the model to practice. Expected outcomes are world first evidence on practice, progress towards effective regulation, and benefits will be reduced conflict and harms.Read moreRead less
Mapping Social Services Provision for Diverse Communities. Although the provision of social services in multicultural societies is one of the major factors that affect immigrants’ integration experiences, it surprisingly remains under-researched. This project will systematically map the provision and impact of different service-delivery modes in three areas of interest to migrant groups - health, social and employment services. By using mixed-methods design, the project will assess the experienc ....Mapping Social Services Provision for Diverse Communities. Although the provision of social services in multicultural societies is one of the major factors that affect immigrants’ integration experiences, it surprisingly remains under-researched. This project will systematically map the provision and impact of different service-delivery modes in three areas of interest to migrant groups - health, social and employment services. By using mixed-methods design, the project will assess the experiences and impact of the mainstreaming of social services on social inclusion, citizenship and human rights among migrant communities. Outcomes will include robust empirical evidence to plan policies and improve social inclusion of migrant communities through the effective provision of social services.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101180
Funder
Australian Research Council
Funding Amount
$327,900.00
Summary
Understanding and preventing road deaths using coronial investigations. This project aims to study coronial death investigations of fatal road crashes in Australia using public health and road safety theoretical frameworks. Fatal road crashes are sudden, unexpected and violent. Each fatality has a lasting effect resulting in immeasurable emotional costs and a financial burden in excess of $3.8 billion per year. Intended outcomes will contribute to understanding of fatal road crashes including pr ....Understanding and preventing road deaths using coronial investigations. This project aims to study coronial death investigations of fatal road crashes in Australia using public health and road safety theoretical frameworks. Fatal road crashes are sudden, unexpected and violent. Each fatality has a lasting effect resulting in immeasurable emotional costs and a financial burden in excess of $3.8 billion per year. Intended outcomes will contribute to understanding of fatal road crashes including pre-crash social factors (e.g. alcohol/drug use and dependence, unemployment, age), the use and effect of coronial recommendations on road safety policy and practice, and preventing deaths on Australian roads.Read moreRead less
A digital twin framework for human mobility measurement in the home setting. Mobility is essential to maintain quality of life and healthy ageing, yet we do not have the capability to perform accurate long-term mobility assessments of a person in their home or community. This project will overcome this engineering challenge by developing a user-friendly ‘digital twin’ that combines wearable sensors, 3D mapping and artificial intelligence to predict and visualise real-time human joint motion and ....A digital twin framework for human mobility measurement in the home setting. Mobility is essential to maintain quality of life and healthy ageing, yet we do not have the capability to perform accurate long-term mobility assessments of a person in their home or community. This project will overcome this engineering challenge by developing a user-friendly ‘digital twin’ that combines wearable sensors, 3D mapping and artificial intelligence to predict and visualise real-time human joint motion and mobility in any location. This digital twin framework will benefit next-generation healthcare for older Australians, including telemedicine and remote rehabilitation for isolated communities, performance monitoring of elite athletes and military personnel, and the gaming and film/animation industries.Read moreRead less