Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Uncovering Sex Specific, Epigenetic Biomarkers Of Healthy Ageing For Targeted Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
The aged population accounts for a significant, and increasing, amount of Australia’s health budget. We aim to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. We will use innovative DNA and protein analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This will underpin the development of evidence-based biomarkers to be used in personalised health interventions.
Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to disco ....Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.Read moreRead less
The relationship between mining companies and mine-affected communities in developing countries. Conflicts with local communities have been a major source of social risk for mining companies operating in Indonesia and other parts of the Asia Pacific region, and this research will contribute to Australian national security by dealing directly with this issue. It will contribute to the formation of better policies and practices for empowering women and empowering communities in the Indonesian mini ....The relationship between mining companies and mine-affected communities in developing countries. Conflicts with local communities have been a major source of social risk for mining companies operating in Indonesia and other parts of the Asia Pacific region, and this research will contribute to Australian national security by dealing directly with this issue. It will contribute to the formation of better policies and practices for empowering women and empowering communities in the Indonesian mining sector. At a regional and global scale, the lessons learnt about the construction of effective strategies for 'engendering' the development process will be applicable in other locations where Australian capital, technology and expertise are invested in large-scale industrial development, both inside and outside of the mining sector.Read moreRead less
Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliv ....Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliver the knowledge to underpin effective psychological safety and mental health guidelines for community sports with national impact. When implemented, this knowledge will help sports clubs to provide a psychologically safe environment, and promote the mental health and wellbeing of all Australians involved in organised sports.Read moreRead less
Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans re ....Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans respond to changing environments during their lifetime, and will underpin the development of evidence-based personalised health interventions to keep Australians healthier for longer.
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Discovery Early Career Researcher Award - Grant ID: DE190100859
Funder
Australian Research Council
Funding Amount
$359,000.00
Summary
The social dynamics of digital design: building an ethics-based industry. This project aims to cultivate socially responsible design practices within the Australian digital start-up industry through an industry-user design ethnography, and the development and delivery of a critical design toolkit for industry participants. Social ills associated with technological design have plagued Silicon Valley in the United States of America. Australia is positioned to avoid these issues while emerging as a ....The social dynamics of digital design: building an ethics-based industry. This project aims to cultivate socially responsible design practices within the Australian digital start-up industry through an industry-user design ethnography, and the development and delivery of a critical design toolkit for industry participants. Social ills associated with technological design have plagued Silicon Valley in the United States of America. Australia is positioned to avoid these issues while emerging as a global leader in ethical design practices. This project will provide Australian start-ups with crucial knowledge to serve diverse populations through thoughtful design decisions, positioning the industry as an exemplar model of social responsibility. This project will advance theories of science and technology studies while positioning Australia as a leading force in social responsibility.Read moreRead less
Asian Women, Migration and Transnational Governance from Below. This project investigates international labour migration and its gender implications in the context of intra-regional flows in Southeast and East Asia.
It evaluates the responses and type(s) of activism by major migrant lobbyists as a potential force for socio-legal change and to what extent they operate beyond national borders. By integrating civil society activism, a novel approach is offered which conceptually combines the analy ....Asian Women, Migration and Transnational Governance from Below. This project investigates international labour migration and its gender implications in the context of intra-regional flows in Southeast and East Asia.
It evaluates the responses and type(s) of activism by major migrant lobbyists as a potential force for socio-legal change and to what extent they operate beyond national borders. By integrating civil society activism, a novel approach is offered which conceptually combines the analysis of women's needs and concerns when migrating internationally with democratisation processes and the increasing acceptance of global norms, nationally and transnationally.
The publication of a single-authored monograph and a number of journal articles is anticipated.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453870
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Social science advanced data modelling, analysis and visualisation facility. This is an integrated facility for advanced social science data analysis, modelling and visualisation located at The University of Queensland. The collaborating institutions are UQ, ANU and Griffith University. The facility promotes deep collaborations between social scientists and quantitative methodologists (statisticians, biostatisticians, econometricians) to enable leading edge quantitative analyses of survey, spati ....Social science advanced data modelling, analysis and visualisation facility. This is an integrated facility for advanced social science data analysis, modelling and visualisation located at The University of Queensland. The collaborating institutions are UQ, ANU and Griffith University. The facility promotes deep collaborations between social scientists and quantitative methodologists (statisticians, biostatisticians, econometricians) to enable leading edge quantitative analyses of survey, spatial and population data, new developments in quantitative methodology for statistical modelling and data visualisation, enhanced international research linkages and advanced postgraduate research training.Read moreRead less
The effect of physical activity and a structured exercise program on the psychological and physical development of Australian primary school children. This study will explore the effects of early childhood physical activity on development. Our study will assess quantitatively the beneficial effects of exercise on personal and physical growth in young children in a non-intimidating way using a specifically designed exercise program.