Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Uncovering Sex Specific, Epigenetic Biomarkers Of Healthy Ageing For Targeted Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
The aged population accounts for a significant, and increasing, amount of Australia’s health budget. We aim to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. We will use innovative DNA and protein analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This will underpin the development of evidence-based biomarkers to be used in personalised health interventions.
Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to disco ....Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.Read moreRead less
Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliv ....Playing it Safe: Psychological Safety and Mental Health for Community Sport. At a time when over half of all Australians participate in organised sports it is critical to ensure that these environments are psychologically safe. The problem is that community sports clubs have no clear guidance on how to fulfil this substantial responsibility. There have been urgent calls for the development of psychological safety and mental health guidelines which have yet to be answered. This project will deliver the knowledge to underpin effective psychological safety and mental health guidelines for community sports with national impact. When implemented, this knowledge will help sports clubs to provide a psychologically safe environment, and promote the mental health and wellbeing of all Australians involved in organised sports.Read moreRead less
Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans re ....Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans respond to changing environments during their lifetime, and will underpin the development of evidence-based personalised health interventions to keep Australians healthier for longer.
Read moreRead less
Activating and maintaining community participation in natural and cultural resources initiatives in the Murray-Darling Basin. The project goes beyond the rhetoric of participation to discover what factors activate communities and individuals to become involved in programs and voluntary initiatives for natural resource management. It assesses the effectiveness of existing communication channels and develops new models for more effective and representative participation. It combines the National M ....Activating and maintaining community participation in natural and cultural resources initiatives in the Murray-Darling Basin. The project goes beyond the rhetoric of participation to discover what factors activate communities and individuals to become involved in programs and voluntary initiatives for natural resource management. It assesses the effectiveness of existing communication channels and develops new models for more effective and representative participation. It combines the National Museum of Australia's expertise in environmental history and public communication with the imperative of the Murray-Darling Basin Commission to improve community participation in natural resource management. The potential for harnessing communications technology to facilitate new channels for participation is assessed through carefully evaluated pilot programs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989083
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Australian Social Science Data Archive: Provision of Advanced Research Infrastructure and Collaborative Environment. The Australian Social Science Data Archive (ASSDA) supports researchers in a wide range of social science and humanities disciplines. These researchers are both primary and secondary users of data collected across a range of economic, social, political and cultural areas. Increasingly, complex public policy problems require multi-disciplinary solutions based on a range of data sou ....Australian Social Science Data Archive: Provision of Advanced Research Infrastructure and Collaborative Environment. The Australian Social Science Data Archive (ASSDA) supports researchers in a wide range of social science and humanities disciplines. These researchers are both primary and secondary users of data collected across a range of economic, social, political and cultural areas. Increasingly, complex public policy problems require multi-disciplinary solutions based on a range of data sources to address these problems. This proposal provides a means for Australia's leading edge researchers to advance the knowledge base that can lead to the development of strong evidence based policy. The open access policies of ASSDA ensures that the general public, media, non-government organisation (NGOs) and government agencies are able to examine the public use data sets that are used by researchers to arrive at their conclusions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100864
Funder
Australian Research Council
Funding Amount
$394,334.00
Summary
Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans. The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This proj ....Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans. The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This project will demonstrate the effects of alpha-actinin-3 deficiency on the characteristics of human muscle pre and post exercise training. Outcomes will include major applications for personalising health recommendations and in designing preventative programs for ageing.Read moreRead less
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Ethnographies of housing: exploring the role of housing officers in public housing service provision. This research examines the everyday practice of public housing officers working in the Victorian Office of Housing. It aims to analyse the ways that workers exercise discretion, and the patterns of meanings that they construct, through their interactions with clients, departmental managers and other human service providers. It is the first ethnographic study of front-line work in housing servi ....Ethnographies of housing: exploring the role of housing officers in public housing service provision. This research examines the everyday practice of public housing officers working in the Victorian Office of Housing. It aims to analyse the ways that workers exercise discretion, and the patterns of meanings that they construct, through their interactions with clients, departmental managers and other human service providers. It is the first ethnographic study of front-line work in housing services in Australia and builds on comparable work done in the United Kingdom and America. The knowledge generated will inform innovation in public housing services, housing policy debates and emerging programs designed to integrate housing with other human services.Read moreRead less