Discovering And Targeting Genes Regulating Skeletal Muscle Function, Metabolism, And Adaptations To Exercise Interventions
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Muscle wasting and decreased in mitochondrial function due to ageing or lack of physical activity are associated with reduced quality of life. The overarching aim is to develop a unique research program focusing on targeting specific genes, and to discover novel genes regulating muscle wasting and mitochondrial (dis)function. I anticipate this approach to assist in the development of targeted and personalised prevention and therapy for diseases associated with muscle (dis)function.
Activating and maintaining community participation in natural and cultural resources initiatives in the Murray-Darling Basin. The project goes beyond the rhetoric of participation to discover what factors activate communities and individuals to become involved in programs and voluntary initiatives for natural resource management. It assesses the effectiveness of existing communication channels and develops new models for more effective and representative participation. It combines the National M ....Activating and maintaining community participation in natural and cultural resources initiatives in the Murray-Darling Basin. The project goes beyond the rhetoric of participation to discover what factors activate communities and individuals to become involved in programs and voluntary initiatives for natural resource management. It assesses the effectiveness of existing communication channels and develops new models for more effective and representative participation. It combines the National Museum of Australia's expertise in environmental history and public communication with the imperative of the Murray-Darling Basin Commission to improve community participation in natural resource management. The potential for harnessing communications technology to facilitate new channels for participation is assessed through carefully evaluated pilot programs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989083
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Australian Social Science Data Archive: Provision of Advanced Research Infrastructure and Collaborative Environment. The Australian Social Science Data Archive (ASSDA) supports researchers in a wide range of social science and humanities disciplines. These researchers are both primary and secondary users of data collected across a range of economic, social, political and cultural areas. Increasingly, complex public policy problems require multi-disciplinary solutions based on a range of data sou ....Australian Social Science Data Archive: Provision of Advanced Research Infrastructure and Collaborative Environment. The Australian Social Science Data Archive (ASSDA) supports researchers in a wide range of social science and humanities disciplines. These researchers are both primary and secondary users of data collected across a range of economic, social, political and cultural areas. Increasingly, complex public policy problems require multi-disciplinary solutions based on a range of data sources to address these problems. This proposal provides a means for Australia's leading edge researchers to advance the knowledge base that can lead to the development of strong evidence based policy. The open access policies of ASSDA ensures that the general public, media, non-government organisation (NGOs) and government agencies are able to examine the public use data sets that are used by researchers to arrive at their conclusions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100864
Funder
Australian Research Council
Funding Amount
$394,334.00
Summary
Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans. The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This proj ....Discovering The Effect of alpha-actinin-3 Deficiency on Muscle Adaptations to Exercise Training in Humans. The protein alpha-actinin-3 is expressed in fast muscle fibres. A common gene variant results in complete deficiency in alpha-actinin-3 that has been shown to influence athletic performance. A mouse model has been previously generated to demonstrate that alpha-actinin-3 deficiency results in a significant shift in fast muscle fibres, towards the slow, more efficient muscle fibres. This project will demonstrate the effects of alpha-actinin-3 deficiency on the characteristics of human muscle pre and post exercise training. Outcomes will include major applications for personalising health recommendations and in designing preventative programs for ageing.Read moreRead less
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Ethnographies of housing: exploring the role of housing officers in public housing service provision. This research examines the everyday practice of public housing officers working in the Victorian Office of Housing. It aims to analyse the ways that workers exercise discretion, and the patterns of meanings that they construct, through their interactions with clients, departmental managers and other human service providers. It is the first ethnographic study of front-line work in housing servi ....Ethnographies of housing: exploring the role of housing officers in public housing service provision. This research examines the everyday practice of public housing officers working in the Victorian Office of Housing. It aims to analyse the ways that workers exercise discretion, and the patterns of meanings that they construct, through their interactions with clients, departmental managers and other human service providers. It is the first ethnographic study of front-line work in housing services in Australia and builds on comparable work done in the United Kingdom and America. The knowledge generated will inform innovation in public housing services, housing policy debates and emerging programs designed to integrate housing with other human services.Read moreRead less
Working late and the spectre of uselessness: Sustaining labour supply in a globalising economy. A buoyant economy and strong employment growth resulting in unfilled vacancies is frustrating business. Population ageing may exacerbate this, reducing labour supply and consequently industrial output. To assist, the Government is recommending increased employment among older workers. As yet, the evidence base for informing actions is inadequate but points to complex scenarios where older workers may ....Working late and the spectre of uselessness: Sustaining labour supply in a globalising economy. A buoyant economy and strong employment growth resulting in unfilled vacancies is frustrating business. Population ageing may exacerbate this, reducing labour supply and consequently industrial output. To assist, the Government is recommending increased employment among older workers. As yet, the evidence base for informing actions is inadequate but points to complex scenarios where older workers may not necessarily fair well. Better understanding the determinants of their employment and of employer actions would help clarify the role of public policy. Also, understanding how other nations are responding is of strategic importance as this will directly influence the Australian labour market.Read moreRead less
Fear and licensing in Australia: Investigating the social licence to operate of an emerging coal seam gas industry. Australia’s nascent coal seam gas (CSG) industry is the site of substantial social tension. For some the industry can transform and safeguard national energy sources and fuel booming Asian exports. For others it damages both the environment and communities. This tension is vividly expressed by local protests and regulatory bans. Communities, mining companies and government invoke a ....Fear and licensing in Australia: Investigating the social licence to operate of an emerging coal seam gas industry. Australia’s nascent coal seam gas (CSG) industry is the site of substantial social tension. For some the industry can transform and safeguard national energy sources and fuel booming Asian exports. For others it damages both the environment and communities. This tension is vividly expressed by local protests and regulatory bans. Communities, mining companies and government invoke a 'social licence to operate' as fundamental to industry viability. This landmark project explores the concept of a social licence to operate in Australia's CSG industry to tease apart the dynamic risks, opportunities and tensions at work between corporations, rural and regional Australian communities and government, and offers policy and practice recommendations. Read moreRead less
Improving employment outcomes for Australians with disability. This project aims to provide evidence about how to improve employment outcomes for people with disability. Nearly one in five adult Australians have a disability and just over half of these are in the labour force; a modest increase in employment rates will have significant social and economic benefits for people with disability and society. By collecting longitudinal quantitative (survey) and qualitative (interview) data at three ti ....Improving employment outcomes for Australians with disability. This project aims to provide evidence about how to improve employment outcomes for people with disability. Nearly one in five adult Australians have a disability and just over half of these are in the labour force; a modest increase in employment rates will have significant social and economic benefits for people with disability and society. By collecting longitudinal quantitative (survey) and qualitative (interview) data at three time points from over 1500 jobseekers with disability, critical information should be gained about how the characteristics of employment services, workplaces and jobseekers contribute to sustainable, meaningful employment for people with disability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453801
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Asia/Pacific HIV/AIDS Database: Support for Regional Policy Research. HIV/AIDS is one of the greatest contemporary threats to global human security, and its rapid growth in parts of the Asia/Pacific region makes it a major concern for Australia. Appropriate responses to the threat require accurate and regularly updated policy information. The construction of an interactive HIV policy data bank will support considerable research in a number of disciplines directly relevant to HIV control. This pr ....Asia/Pacific HIV/AIDS Database: Support for Regional Policy Research. HIV/AIDS is one of the greatest contemporary threats to global human security, and its rapid growth in parts of the Asia/Pacific region makes it a major concern for Australia. Appropriate responses to the threat require accurate and regularly updated policy information. The construction of an interactive HIV policy data bank will support considerable research in a number of disciplines directly relevant to HIV control. This project draws on multiple sources to construct a research and policy tool which will be drawn on by the partner organizations in a variety of HIV-related research projects.
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