Use of heart rate kinetics during the rest-exercise transition for tracking changes in exercise performance in athletes. The project aims to develop an objective method for assessing fatigue and recovery in athletes during changes in training load. It is intended that this will inform training adjustments to optimise performance and reduce the risk of overtraining and injury. The method assesses the maximal rate of heart rate increase at the start of light exercise (rHRI), and has been shown in ....Use of heart rate kinetics during the rest-exercise transition for tracking changes in exercise performance in athletes. The project aims to develop an objective method for assessing fatigue and recovery in athletes during changes in training load. It is intended that this will inform training adjustments to optimise performance and reduce the risk of overtraining and injury. The method assesses the maximal rate of heart rate increase at the start of light exercise (rHRI), and has been shown in the project team’s early studies to track reductions in exercise performance when an athlete is fatigued from increased training. The project aims to now refine rHRI so it can also track improvements in exercise performance as athletes recover, and to evaluate rHRI in multiple sports and genders. A field test will be developed and mechanisms that allow it to track changes in exercise performance will be investigated.Read moreRead less
An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical perfo ....An investigation into performance characteristics of elite male and female soccer players in training and competition environments. The aim of the project is to identify critical determinants of soccer performance that will improve preparation of Australian teams for international competition. Three studies are proposed. Study One will utilize a decade of physical performance and anthropometric data on male and female soccer players at the Australian Institute of Sport to identify physical performance standards characteristic of elite players. Study Two will comprise match analyses to delineate crucial physical, technical and tactical aspects of individual and team performance. Study three will identify characteristics specific to elite goalkeepers that may be used for monitoring responses to training and competition.Read moreRead less
Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self- ....Effectiveness of Intervention Strategies to Promote Physical Activity Among Insufficiently Active Adults. This project will determine the cost-effectiveness of 2 types of physical activity (PA) interventions based around the workplace. 480 participants will be randomly assigned to PA intervention groups or controls. Interventions are either a (1) self-regulated, pedometer-based program or a (2) semi-structured, 40-day initiation to more moderately-vigorous PA. Both are designed to increase self-efficacy and impact on positive PA behaviours. Long-term, behavioural change and job-related outcomes will be evaluated by following participants for 12 months after the interventions.Read moreRead less
Femoral microarchitecture, strength and locomotion in adult people. This project aims at unravelling the load bearing capacity of human femora microarchitecture. The project will quantify the relationship between geometry, microarchitecture, strain and strength in adult people during normal and accidental motor tasks using micro-computed-tomography images, motion data, supercomputing technology and multivariate statistic. It will benefit the design of novel implantable devices, enhance exercise ....Femoral microarchitecture, strength and locomotion in adult people. This project aims at unravelling the load bearing capacity of human femora microarchitecture. The project will quantify the relationship between geometry, microarchitecture, strain and strength in adult people during normal and accidental motor tasks using micro-computed-tomography images, motion data, supercomputing technology and multivariate statistic. It will benefit the design of novel implantable devices, enhance exercise therapies and diagnostic techniques for promoting hip strength. The project will contribute to the engineering of biological tissue and the development of high-strength and light-weight bio-inspired materials.Read moreRead less
Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental condition ....Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental conditions (especially exposure to steroid-like pollutants) is crucial to support breeding programs of endangered species and may improve veterinary and medicinal treatment of premature animals and humans. This multi-disciplinary, international collaboration provides an international training ground and two-way exchange of students and postdocs.Read moreRead less
Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
A new paradigm for surfactant composition and function - how do lungs cope with stress? Our research will increase the understanding of the scope of change and precise molecular interactions occurring in the surfactant lipids and proteins of animals under physiological stress. The novel insights will improve the treatment of lung diseases (such as chronic obstructive pulmonary disease and acute lung injury). We have formed a team of international surfactant researchers all experts in state-of-th ....A new paradigm for surfactant composition and function - how do lungs cope with stress? Our research will increase the understanding of the scope of change and precise molecular interactions occurring in the surfactant lipids and proteins of animals under physiological stress. The novel insights will improve the treatment of lung diseases (such as chronic obstructive pulmonary disease and acute lung injury). We have formed a team of international surfactant researchers all experts in state-of-the-art chemical and biophysical technologies relating to surfactant. These collaborations will bring new technological applications to Australia and provide outstanding cross-disciplinary training for postgraduate students and research staff at the interface between animal physiology, biophysical chemistry and respiratory medicine.Read moreRead less
Epigenetic Regulation of Fetal and Placental Development. Perturbations of the environment of the early embryo can alter fetal and placental growth. The mechanisms by which the early environment alters development of the fetal adrenal-placental axis are unknown. This axis coordinates fetal growth and development to ensure a successful transition from intra- to extrauterine life. We propose a novel role for the epigenetic regulation of imprinted genes in the activation of the fetal adrenal and in ....Epigenetic Regulation of Fetal and Placental Development. Perturbations of the environment of the early embryo can alter fetal and placental growth. The mechanisms by which the early environment alters development of the fetal adrenal-placental axis are unknown. This axis coordinates fetal growth and development to ensure a successful transition from intra- to extrauterine life. We propose a novel role for the epigenetic regulation of imprinted genes in the activation of the fetal adrenal and in placental growth and differentiation. This proposal extends the 'genetic conflict' hypothesis of the role of imprinted genes beyond its current focus on the regulation of fetal nutrient supply and demand.Read moreRead less
Defining how serotonin regulates gut motility. This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important ....Defining how serotonin regulates gut motility. This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important for our health. This project expects to define how serotonin controls peristalsis, where in the bowel this serotonin comes from, how serotonin communicates with the nervous system in our gastrointestinal tract, and how the cells that synthesise gut serotonin respond to contraction to trigger the secretion of serotonin.Read moreRead less
Examining the links between obesity and insulin resistance. Obesity prevalence is rapidly increasing in Australia and contributes to the onset of many chronic diseases, such as diabetes, heart disease and cancer. This project will examine how obesity contributes to disease risk and how modifying nutrient delivery and other interventions that protect from cellular stress reduces these risks.